제2형 당뇨병 환자에서 혈청 C-reactive protein과 인슐린 저항성과의 관계 Relationship between the serum c-reactive protein concentration and insulin resistance in type 2 diabetic patients원문보기
목적 : 염증반응은 죽상경화증의 주요 병인이다. 제2형 당뇨병 환자를 대상으로 염증 반응의 표지자로 알려진 CRP와 인슐린 저항성과의 상관관계를 살펴보고자 하였다. 방법 : 평균유병기간이 8.5년인 제 2형 당뇨병 환자 102명을 대상으로 하였다. CRP와 HOMA-IR과의 상관관계 및 대사 위험 요소들 간의 연관성을 분석하였다. 결과 : CRP값은 HOMA-IR값과 양의 상관관계를 보였으며(r=0.4, p<0.01), 특히 공복시 인슐린과 밀접한 상관관계를 보였다(r=0.319, p=0.001). 대상군을 CRP 값 1 mg/L를 기준으로 구분하였을 때 1 mg/L이상인 군에서 1 mg/L미만인 군에 비하여 유의하게 높은 HOMA-IR 값의 분포 양상을 보였다(p=0.001). 공복시 인슐린, 지질, 고혈압 유무로 보정을 한 후에도 이러한 상관관계는 지속되었다. 결론 : 본 연구에서는 제2형 당뇨병 환자에 있어 CRP가 정상 범위내에 있을지라도, 정상 범위내에서 HOMA-IR 값과 양의 상관관계를 가진다는 것을 알 수 있었다. 향후 예후와 관련된 의미있는 CRP 상승의 정도 규명 및 이러한 CRP 상승을 일으키는 HOMA-IR 값에 대한 추가적인 연구들이 필요하다.
목적 : 염증반응은 죽상경화증의 주요 병인이다. 제2형 당뇨병 환자를 대상으로 염증 반응의 표지자로 알려진 CRP와 인슐린 저항성과의 상관관계를 살펴보고자 하였다. 방법 : 평균유병기간이 8.5년인 제 2형 당뇨병 환자 102명을 대상으로 하였다. CRP와 HOMA-IR과의 상관관계 및 대사 위험 요소들 간의 연관성을 분석하였다. 결과 : CRP값은 HOMA-IR값과 양의 상관관계를 보였으며(r=0.4, p<0.01), 특히 공복시 인슐린과 밀접한 상관관계를 보였다(r=0.319, p=0.001). 대상군을 CRP 값 1 mg/L를 기준으로 구분하였을 때 1 mg/L이상인 군에서 1 mg/L미만인 군에 비하여 유의하게 높은 HOMA-IR 값의 분포 양상을 보였다(p=0.001). 공복시 인슐린, 지질, 고혈압 유무로 보정을 한 후에도 이러한 상관관계는 지속되었다. 결론 : 본 연구에서는 제2형 당뇨병 환자에 있어 CRP가 정상 범위내에 있을지라도, 정상 범위내에서 HOMA-IR 값과 양의 상관관계를 가진다는 것을 알 수 있었다. 향후 예후와 관련된 의미있는 CRP 상승의 정도 규명 및 이러한 CRP 상승을 일으키는 HOMA-IR 값에 대한 추가적인 연구들이 필요하다.
Background/Aims : Low grade inflammation has been suggested to be a risk factor for development of atherosclerosis. C-reactive protein (CRP) is very sensitive acute phase reactant, and it is considered as an important marker of atherosclerosis and related disorder. Insulin resistance is also known t...
Background/Aims : Low grade inflammation has been suggested to be a risk factor for development of atherosclerosis. C-reactive protein (CRP) is very sensitive acute phase reactant, and it is considered as an important marker of atherosclerosis and related disorder. Insulin resistance is also known to be associated with atherosclerosis. However, the relationship between insulin resistance and CRP has not been thoroughly studied in patients with type 2 diabetes. This study aimed to determine whether insulin resistance in type 2 diabetes is related with CRP. Methods : 102 subjects with type 2 diabetes were included in the study. Fasting blood samples were taken for measurement for CRP, insulin and glucose. To estimate insulin resistance, the HOMA (homeostasis model assessment)-IR (insulin resistance) was calculated by the standard formula. We divided the subjects into two groups depending on their CRP levels (Group A: <1 mg/L, Group B: ≥1 mg/L), and analyzed HOMA-IR indexes in each group. Results : There was significant correlation between CRP and HOMA-IR (r=0.4, p<0.01). HOMA-IR and fasting insulin levels in group B were higher than that of group A on the univariate analysis. On the multivariate analysis, among several variables such as fasting insulin, HOMA-IR, total cholesterol, and triglyceride, HOMA-IR were significantly related with CRP level independently. Conclusions : The serum CRP level, even if existed in normal range, was positively correlated with HOMA-IR in type 2 diabetes. Further studies are needed to determine the CRP level considered as clinically significant, and relating HOMA-IR.
Background/Aims : Low grade inflammation has been suggested to be a risk factor for development of atherosclerosis. C-reactive protein (CRP) is very sensitive acute phase reactant, and it is considered as an important marker of atherosclerosis and related disorder. Insulin resistance is also known to be associated with atherosclerosis. However, the relationship between insulin resistance and CRP has not been thoroughly studied in patients with type 2 diabetes. This study aimed to determine whether insulin resistance in type 2 diabetes is related with CRP. Methods : 102 subjects with type 2 diabetes were included in the study. Fasting blood samples were taken for measurement for CRP, insulin and glucose. To estimate insulin resistance, the HOMA (homeostasis model assessment)-IR (insulin resistance) was calculated by the standard formula. We divided the subjects into two groups depending on their CRP levels (Group A: <1 mg/L, Group B: ≥1 mg/L), and analyzed HOMA-IR indexes in each group. Results : There was significant correlation between CRP and HOMA-IR (r=0.4, p<0.01). HOMA-IR and fasting insulin levels in group B were higher than that of group A on the univariate analysis. On the multivariate analysis, among several variables such as fasting insulin, HOMA-IR, total cholesterol, and triglyceride, HOMA-IR were significantly related with CRP level independently. Conclusions : The serum CRP level, even if existed in normal range, was positively correlated with HOMA-IR in type 2 diabetes. Further studies are needed to determine the CRP level considered as clinically significant, and relating HOMA-IR.
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