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Abstract ▼ AI-Helper

Background : It is well known that low BMI and younger age are associated with high breast density in western women, but there is a lack of researchin Korean women. Mammographic dense breast has been reported both as a cause of false-negative findings on mammography and as an indicator of increased ...

Background : It is well known that low BMI and younger age are associated with high breast density in western women, but there is a lack of researchin Korean women. Mammographic dense breast has been reported both as a cause of false-negative findings on mammography and as an indicator of increased breast cancer risk. The purpose of this study was to evaluate the relationship between breast density and BMI. Furthermore, we considered proper screening method of breast cancer in Korean women. Methods : From February 2000 to March 2006, 16,482 asymptomatic women who underwent screening mammography in the health promotion center were included. Those with prior history of breast cancer or breast surgery were excluded. Breast density distribution and further breast sonography recommendation rate were evaluated. Results : 25.9% of women (n=4,275) had dense breasts. Both Age and BMI were negatively associated with breast density respectively (P < 0.001, P < 0.001). BMI after adjusting for age was negatively associated with breast density (OR of underweight 1.381, 95% CI 1.139-1.674; OR of overweight 0.792, 95% CI 0.723-0.868; OR of obesity 0.540, 95% CI 0.488-0.597; OR of severe obesity 0.298, 95% CI 0.217-0.409). 17.8% (n=2,939) of women were recommended further breast sonography due to low sensitivity of mammography. Young age and low BMI were associated with sonography recommendation rate (P < 0.001, P < 0.001). Conclusions : BMI is negatively associated with breast density after adjusting for age. Mammography combined with breast sonography may increase sensitivity of breast cancer screening in especially young and thin women in Korea.

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