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Methods in Mammalian Autophagy Research 원문보기

Cell, v.140 no.3, 2010년, pp.313 - 326  

Mizushima, Noboru (Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan) ,  Yoshimori, Tamotsu (Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan) ,  Levine, Beth (Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA)

Abstract AI-Helper 아이콘AI-Helper

Autophagy has been implicated in many physiological and pathological processes. Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate the process of autophagy. However, as autophagy involves dynamic and complicated processes, it is often analyzed incorrectl...

참고문헌 (86)

  1. Autophagy Bampton 1 23 2005 10.4161/auto.1.1.1495 The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes 

  2. J. Cell Biol. Bjørkøy 171 603 2005 10.1083/jcb.200507002 p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death 

  3. Eur. J. Biochem. Blommaart 243 240 1997 10.1111/j.1432-1033.1997.0240a.x The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes 

  4. EMBO J. Brunn 15 5256 1996 10.1002/j.1460-2075.1996.tb00911.x Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002 

  5. Nature Cadwell 456 259 2008 10.1038/nature07416 A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells 

  6. Dev. Dyn. Cann 237 187 2007 10.1002/dvdy.21392 Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice 

  7. Eur. J. Biochem. Caro 175 325 1988 10.1111/j.1432-1033.1988.tb14200.x 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism 

  8. Dev. Cell Cecconi 15 344 2008 10.1016/j.devcel.2008.08.012 The role of autophagy in mammalian development: cell makeover rather than cell death 

  9. J. Biol. Chem. Chan 282 25464 2007 10.1074/jbc.M703663200 siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy 

  10. Mol. Cell. Biol. Chan 29 157 2009 10.1128/MCB.01082-08 Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism 

  11. Cell Host Microbe Deretic 5 527 2009 10.1016/j.chom.2009.05.016 Autophagy, immunity, and microbial adaptations 

  12. Autophagy Eskelinen 4 257 2008 10.4161/auto.5179 To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells 

  13. PLoS Biol. Feldman 7 e38 2009 10.1371/journal.pbio.1000038 Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 

  14. Nature Fimia 447 1121 2007 10.1038/nature05925 Ambra1 regulates autophagy and development of the nervous system 

  15. Mol. Biol. Cell Fujita 19 4651 2008 10.1091/mbc.e08-03-0312 An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure 

  16. Mol. Biol. Cell Fujita 19 2092 2008 10.1091/mbc.e07-12-1257 The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy 

  17. J. Cell Biol. Gan 175 121 2006 10.1083/jcb.200604129 Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways 

  18. Autophagy Gao 4 754 2008 10.4161/auto.6360 Induction of macroautophagy by exogenously introduced calcium 

  19. J. Cell Biol. Hara 181 497 2008 10.1083/jcb.200712064 FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells 

  20. Annu. Rev. Genet. He 43 67 2009 10.1146/annurev-genet-102808-114910 Regulation mechanisms and signaling pathways of autophagy 

  21. Autophagy He 5 520 2009 10.4161/auto.5.4.7768 Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos 

  22. FEBS Lett. Hosokawa 580 2623 2006 10.1016/j.febslet.2006.04.008 Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size 

  23. Mol. Biol. Cell Hosokawa 20 1981 2009 10.1091/mbc.e08-12-1248 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy 

  24. Mol. Biol. Cell Itakura 19 5360 2008 10.1091/mbc.e08-01-0080 Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG 

  25. Autophagy Iwai-Kanai 4 322 2008 10.4161/auto.5603 A method to measure cardiac autophagic flux in vivo 

  26. Traffic Jahreiss 9 574 2008 10.1111/j.1600-0854.2008.00701.x The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes 

  27. EMBO J. Kabeya 19 5720 2000 10.1093/emboj/19.21.5720 LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing 

  28. J. Biol. Chem. Kamimoto 281 4467 2006 10.1074/jbc.M509409200 Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity 

  29. Cell Struct. Funct. Katayama 33 1 2008 10.1247/csf.07011 GFP-like proteins stably accumulate in lysosomes 

  30. Autophagy Kimura 3 452 2007 10.4161/auto.4451 Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 

  31. Cell Struct. Funct. Kimura 33 109 2008 10.1247/csf.08005 Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes 

  32. Autophagy Klionsky 4 151 2008 10.4161/auto.5338 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes 

  33. Autophagy Klionsky 4 849 2008 10.4161/auto.6845 Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? 

  34. Cell Knight 125 733 2006 10.1016/j.cell.2006.03.035 A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling 

  35. J. Cell Biol. Komatsu 169 425 2005 10.1083/jcb.200412022 Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice 

  36. Cell Komatsu 131 1149 2007 10.1016/j.cell.2007.10.035 Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice 

  37. Nat. Rev. Mol. Cell Biol. Kroemer 9 1004 2008 10.1038/nrm2529 Autophagic cell death: the story of a misnomer 

  38. Nature Kuma 432 1032 2004 10.1038/nature03029 The role of autophagy during the early neonatal starvation period 

  39. Autophagy Kuma 3 323 2007 10.4161/auto.4012 LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization 

  40. Blood Kundu 112 1493 2008 10.1182/blood-2008-02-137398 Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation 

  41. Cell Levine 132 27 2008 10.1016/j.cell.2007.12.018 Autophagy in the pathogenesis of disease 

  42. Cell Death Differ. Longatti 16 956 2009 10.1038/cdd.2009.39 Vesicular trafficking and autophagosome formation 

  43. EMBO J. Maiuri 26 2527 2007 10.1038/sj.emboj.7601689 Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1 

  44. J. Biol. Chem. Mariño 282 18573 2007 10.1074/jbc.M701194200 Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3 

  45. Circ. Res. Matsui 100 914 2007 10.1161/01.RES.0000261924.76669.36 Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy 

  46. Nat. Cell Biol. Matsunaga 11 385 2009 10.1038/ncb1846 Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages 

  47. Science Meléndez 301 1387 2003 10.1126/science.1087782 Autophagy genes are essential for dauer development and life-span extension in C. elegans 

  48. Int. J. Biochem. Cell Biol. Mizushima 36 2491 2004 10.1016/j.biocel.2004.02.005 Methods for monitoring autophagy 

  49. Autophagy Mizushima 3 542 2007 10.4161/auto.4600 How to interpret LC3 immunoblotting 

  50. J. Cell Biol. Mizushima 152 657 2001 10.1083/jcb.152.4.657 Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells 

  51. Mol. Biol. Cell Mizushima 15 1101 2004 10.1091/mbc.e03-09-0704 In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker 

  52. Nature Mizushima 451 1069 2008 10.1038/nature06639 Autophagy fights disease through cellular self-digestion 

  53. Brain Res. Nakaso 1012 42 2004 10.1016/j.brainres.2004.03.029 Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease 

  54. Autophagy Nishiyama 3 591 2007 10.4161/auto.4964 Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death 

  55. Eur. J. Cell Biol. Punnonen 65 14 1994 3-Methyladenine inhibits transport from late endosomes to lysosomes in cultured rat and mouse fibroblasts 

  56. J. Biol. Chem. Pyo 280 20722 2005 10.1074/jbc.M413934200 Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death 

  57. J. Clin. Invest. Qu 112 1809 2003 10.1172/JCI20039 Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene 

  58. Nat. Genet. Ravikumar 36 585 2004 10.1038/ng1362 Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease 

  59. Nature Rubinsztein 443 780 2006 10.1038/nature05291 The roles of intracellular protein-degradation pathways in neurodegeneration 

  60. Nat. Rev. Drug Discov. Rubinsztein 6 304 2007 10.1038/nrd2272 Potential therapeutic applications of autophagy 

  61. Autophagy Rubinsztein 5 585 2009 10.4161/auto.5.5.8823 In search of an “autophagomometer” 

  62. Dev. Cell Rusten 7 179 2004 10.1016/j.devcel.2004.07.005 Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway 

  63. Nature Saitoh 456 264 2008 10.1038/nature07383 Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production 

  64. Proc. Natl. Acad. Sci. USA. Saitoh 2009 10.1073/pnas.0911267106 Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response 

  65. J. Biol. Chem. Sarkar 282 5641 2007 10.1074/jbc.M609532200 Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein 

  66. Nat. Chem. Biol. Sarkar 3 331 2007 10.1038/nchembio883 Small molecules enhance autophagy and reduce toxicity in Huntington's disease models 

  67. Hum. Mol. Genet. Sarkar 17 170 2008 10.1093/hmg/ddm294 A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin 

  68. Dev. Cell Scott 7 167 2004 10.1016/j.devcel.2004.07.009 Role and regulation of starvation-induced autophagy in the Drosophila fat body 

  69. Autophagy Shvets 4 621 2008 10.4161/auto.5939 Utilizing flow cytometry to monitor autophagy in living mammalian cells 

  70. Mol. Biol. Cell Sou 19 4762 2008 10.1091/mbc.e08-03-0309 The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice 

  71. EMBO J. Suzuki 20 5971 2001 10.1093/emboj/20.21.5971 The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation 

  72. Autophagy Tanida 1 84 2005 10.4161/auto.1.2.1697 Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy 

  73. Autophagy Tanida 4 131 2008 10.4161/auto.5233 Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls 

  74. Proc. Natl. Acad. Sci. USA Tannous 105 9745 2008 10.1073/pnas.0706802105 Autophagy is an adaptive response in desmin-related cardiomyopathy 

  75. J. Biol. Chem. Thoreen 284 8023 2009 10.1074/jbc.M900301200 An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 

  76. Traffic van der Vaart 9 281 2008 10.1111/j.1600-0854.2007.00674.x A picky eater: exploring the mechanisms of selective autophagy in human pathologies 

  77. Nat. Immunol. Virgin 10 461 2009 10.1038/ni.1726 Autophagy genes in immunity 

  78. J. Neurosci. Wang 26 8057 2006 10.1523/JNEUROSCI.2261-06.2006 Induction of autophagy in axonal dystrophy and degeneration 

  79. Nat. Chem. Biol. Williams 4 295 2008 10.1038/nchembio.79 Novel targets for Huntington's disease in an mTOR-independent autophagy pathway 

  80. Biochem. Pharmacol. Xue 64 441 2002 10.1016/S0006-2952(02)01181-4 Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues 

  81. Cell Struct. Funct. Yamamoto 23 33 1998 10.1247/csf.23.33 Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells 

  82. Plant Cell Yoshimoto 16 2967 2004 10.1105/tpc.104.025395 Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy 

  83. Proc. Natl. Acad. Sci. USA Yue 100 15077 2003 10.1073/pnas.2436255100 Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor 

  84. J. Cell Sci. Zeng 119 259 2006 10.1242/jcs.02735 Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking 

  85. Proc. Natl. Acad. Sci. USA Zhang 104 19023 2007 10.1073/pnas.0709695104 Small molecule regulators of autophagy identified by an image-based high-throughput screen 

  86. J. Clin. Invest. Zhu 117 1782 2007 10.1172/JCI27523 Cardiac autophagy is a maladaptive response to hemodynamic stress 

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