$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Prostaglandin E2, an Immunoactivator 원문보기

Journal of pharmacological sciences, v.112 no.1, 2010년, pp.1 - 5  

Sakata, Daiji (Department of Pharmacology, Kyoto University Faculty of Medicine, Japan) ,  Yao, Chengcan (Department of Pharmacology, Kyoto University Faculty of Medicine, Japan) ,  Narumiya, Shuh (Department of Pharmacology, Kyoto University Faculty of Medicine, Japan)

Abstract AI-Helper 아이콘AI-Helper

Diseases caused by immune inflammation, such as rheumatoid arthritis, multiple sclerosis, and Crohn’s disease, are intractable diseases to which novel therapeutics are highly demanded. Prostaglandin (PG) E2 is the most ubiquitously produced PG with various actions. PGE2 has been traditionally ...

주제어

참고문헌 (30)

  1. Zhu, Jinfang, Paul, William E.. CD4 T cells: fates, functions, and faults. Blood, vol.112, no.5, 1557-1569.

  2. 10.1038/nm1551 2 Steinman L. A brief history of T H 17, the first major revision in the T H 1/T H 2 hypothesis of T cell-mediated tissue damage. Nat Med. 2007;13:139–145. 

  3. 0732-0582 KORN THOMAS 27 485 2009 10.1146/annurev.immunol.021908.132710 

  4. 10.1254/jjp.83.279 4 Ushikubi F, Sugimoto Y, Ichikawa A, Narumiya S. Roles of prostanoids revealed from studies using mice lacking specific prostanoids receptors. J Pharmacol Sci. 2000;83:279–285. 

  5. Narumiya, Shuh. Physiology and pathophysiology of prostanoid receptors. Proceedings of the Japan Academy. Series B, physical and biological sciences, vol.83, no.9, 296-319.

  6. Harris, Sarah G, Padilla, Josue, Koumas, Laura, Ray, Denise, Phipps, Richard P. Prostaglandins as modulators of immunity. Trends in immunology, vol.23, no.3, 144-150.

  7. Goodwin, James S., Ceuppens, Jan. Regulation of the immune response by prostaglandins. Journal of clinical immunology, vol.3, no.4, 295-315.

  8. 10.4049/jimmunol.131.2.768 8 Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB. Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. J Immunol 1983;131:768–772. 

  9. 10.4049/jimmunol.146.1.108 9 Betz M, Fox BS. Prostaglandin E 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J Immunol. 1991;146:108–113. 

  10. 10.1002/art.1780370623 10 Gold KN, Weyand CM, Goronzy JJ. Modulation of helper T cell function by prostaglandins. Arthritis Rheum. 1994;37:925–933. 

  11. Hilkens, Catharien M. U., Vermeulen, Hans, van Neerven, R. J. Joost, Snijdewint, Frank G. M., Wierenga, Eddy A., Kapsenber, Martien L.. Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin‐2. European journal of immunology, vol.25, no.1, 59-63.

  12. 10.1371/journal.ppat.1000325 12 Rossi Paccani S, Benagiano M, Capitani N, Zornetta I, Ladant D, Montecucco C, et al. The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling. PLoS Pathog. 2009;5:e1000325. 

  13. 10.1016/j.peptides.2007.03.015 13 Liu L, Yen JH, Ganea D. A novel VIP signaling pathway in T cells cAMP→protein tyrosine phosphatase (SHP-2?)→JAK2/STAT4→Th1 differentiation. Peptides. 2007;28:1814–1824. 

  14. Sugimoto, Yukihiko, Narumiya, Shuh. Prostaglandin E Receptors. The Journal of biological chemistry, vol.282, no.16, 11613-11617.

  15. Nataraj, Chandra, Thomas, Dennis W., Tilley, Stephen L., Nguyen, MyTrang, Mannon, Roslyn, Koller, Beverly H., Coffman, Thomas M.. Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse. The Journal of clinical investigation, vol.108, no.8, 1229-1235.

  16. 10.1182/blood-2002-06-1665 16 Grader-Beck T, van Puijenbroek AAFL, Nadler LM, Boussiotis VA. cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood. 2003;101:998–1006. 

  17. MUSTELIN, Tomas, TASKÉN, Kjetil. Positive and negative regulation of T-cell activation through kinases and phosphatases. The Biochemical journal, vol.371, no.1, 15-27.

  18. 10.1158/0008-5472.CAN-05-3252 18 Chemnitz JM, Driesen J, Classen S, Riley JL, Debey S, Beyer M, et al. Prostaglandin E 2 impairs CD4 + T cell activation by inhibition of lck: implications in Hodgkin’s lymphoma. Cancer Res. 2006;66:1114–1122. 

  19. 10.1038/nm.1968 19 Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S. Prostaglandin E 2 -EP4 signaling promotes immune inflammation through T H 1 cell differentiation and T H 17 cell expansion. Nat Med. 2009;15:633–640. 

  20. Chen, Haiying, Qin, Jin, Wei, Ping, Zhang, Jingge, Li, Qiaoxia, Fu, Lihong, Li, Shujin, Ma, Chunling, Cong, Bin. Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells. Prostaglandins, leukotrienes, and essential fatty acids, vol.80, no.4, 195-200.

  21. 10.1096/fj.03-1367fje 21 Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D. Prostaglandin E 2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J. 2004;18:1318–1320 

  22. 10.4049/jimmunol.181.1.721 22 Khayrullina T, Yen JH, Jing H, Ganea D. In vitro differentiation of dendritic cells in the presence of prostaglandin E 2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. J Immunol. 2008;181:721–735. 

  23. 10.1084/jem.20082293 23 Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, et al. Prostaglandin E 2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009;206:535–548. 

  24. 10.1182/blood-2008-05-155408 24 Chizzolini C, Chicheportiche R, Alvarez M, de Rham C, Roux-Lombard P, Ferrari-Lacraz S, et al. Prostaglandin E 2 synergistically with interleukin-23 favors human Th17 expansion. Blood. 2008;112:3696–3703. 

  25. Napolitani, Giorgio, Acosta‐Rodriguez, Eva V., Lanzavecchia, Antonio, Sallusto, Federica. Prostaglandin E2 enhances Th17 responses via modulation of IL‐17 and IFN‐γ production by memory CD4+ T cells. European journal of immunology, vol.39, no.5, 1301-1312.

  26. 10.1002/art.22794 26 Sheibanie AF, Khayrullina T, Safadi FF, Ganea D. Prostaglandin E 2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis. Aethritis Rheum. 2007;56:2608–2619. 

  27. 10.4049/jimmunol.178.12.8138 27 Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, et al. The proinflammatory effect of prostaglandin E 2 in experimental inflammatory bowel disease is mediated through the IL-23→IL-17 axis. J Immunol. 2007;178:8138–8147. 

  28. 10.1371/journal.pgen.0030058 28 Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet. 2007;20:e58. 

  29. 10.1172/JCI200214459 

  30. 10.1002/ibd.21080 30 Nakase H, Fujiyama Y, Oshitani N, Oga T, Nonomura K, Matsuoka T, et al. Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: A randomized phase II, placebo-controlled trial. Inflamm Bowel Dis. 2009; DOI:10.1002/ibd.21080. 

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로