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Aging cell, v.9 no.2, 2010년, pp.113 - 125
Huang, Junjiu (Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33647, USA) , Okuka, Maja (Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33647, USA) , Wang, Fang (School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China) , Zuo, Bingfeng (College of Life Sciences, Nankai University, Tianjin 300071, China) , Liang, Ping (Department of Biological Sciences, Brock University, Ontario L2S 3A1, Canada) , Kalmbach, Keri (Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33647, USA) , Liu, Lin (Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33647, USA) , Keefe, David L. (Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33647, USA)
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SummaryOocytes can reprogram genomes to form embryonic stem (ES) cells. Although ES cells largely escape senescence, oocytes themselves do senesce in the ovaries of most mammals. It remains to be determined whether ES cells can be established using eggs from old females, which exhibit reproductive s...
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