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Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma 원문보기

Allergy, asthma & immunology research, v.2 no.2, 2010년, pp.127 - 133  

Oh, Kyu-Young (Korean Minjok Leadership Academy, Korea.) ,  Kang, Mi-Jin (Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.) ,  Choi, Won-Ah (Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.) ,  Kwon, Ji-Won (Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) ,  Kim, Byoung-Ju (Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) ,  Yu, Jinho (Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) ,  Hong, Soo-Jong (Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)

Abstract AI-Helper 아이콘AI-Helper

PurposeT cells play a central role in cell-mediated immunity, atopic disease, and asthma. The balance of CD28/cytotoxic T-lymphocyte antigen 4 (CTLA4)-derived signal transduction plays an important role in the activation of T cells and an increased immunoglobulin E (IgE) response. The aim of the cur...

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참고문헌 (16)

  1. 1 Robinson DS Hamid Q Ying S Tsicopoulos A Barkans J Bentley AM Corrigan C Durham SR Kay AB Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma N Engl J Med 1992 326 298 304 1530827 

  2. 2 Kay AB Allergy and allergic diseases. First of two parts N Engl J Med 2001 344 30 37 11136958 

  3. 3 Schweitzer AN Sharpe AH Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production J Immunol 1998 161 2762 2771 9743334 

  4. 4 Hofer MF Jirapongsananuruk O Trumble AE Leung DY Upregulation of B72, but not B71, on B cells from patients with allergic asthma J Allergy Clin Immunol 1998 101 96 102 9449507 

  5. 5 Van Oosterhout AJ Hofstra CL Shields R Chan B Van Ark I Jardieu PM Nijkamp FP Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma Am J Respir Cell Mol Biol 1997 17 386 392 9308926 

  6. 6 A genome-wide The Collaborative Study on the Genetics of Asthma (CSGA) Nat Genet 1997 15 389 392 9090385 

  7. 7 Koppelman GH Stine OC Xu J Howard TD Zheng SL Kauffman HF Bleecker ER Meyers DA Postma DS Genome-wide search for atopy susceptibility genes in Dutch families with asthma J Allergy Clin Immunol 2002 109 498 506 11897998 

  8. 8 Howard TD Postma DS Hawkins GA Koppelman GH Zheng SL Wysong AK Xu J Meyers DA Bleecker ER Fine mapping of an IgEcontrolling gene on chromosome 2q: Analysis of CTLA4 and CD28 J Allergy Clin Immunol 2002 110 743 751 12417883 

  9. 9 Lee SY Lee YH Shin C Shim JJ Kang KH Yoo SH In KH Association of asthma severity and bronchial hyperresponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene Chest 2002 122 171 176 12114354 

  10. 10 Hizawa N Yamaguchi E Jinushi E Konno S Kawakami Y Nishimura M Increased total serum IgE levels in patients with asthma and promoter polymorphisms at CTLA4 and FCER1B J Allergy Clin Immunol 2001 108 74 79 11447385 

  11. 11 Dombrowicz D Lin S Flamand V Brini AT Koller BH Kinet JP Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses Immunity 1998 8 517 529 9586641 

  12. 12 Hizawa N Maeda Y Konno S Fukui Y Takahashi D Nishimura M Genetic polymorphisms at FCER1B and PAI-1 and asthma susceptibility Clin Exp Allergy 2006 36 872 876 16839401 

  13. 13 Hizawa N Yamaguchi E Jinushi E Kawakami Y A common FCER1B gene promoter polymorphism influences total serum IgE levels in a Japanese population Am J Respir Crit Care Med 2000 161 906 909 10712341 

  14. 14 Standards for COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986 Am Rev Respir Dis 1987 136 225 244 3605835 

  15. 15 Lee SG Kim BS Kim JH Lee SY Choi SO Shim JY Hong TJ Hong SJ Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma Clin Exp Allergy 2004 34 1202 1208 15298559 

  16. 16 Heinzmann A Plesnar C Kuehr J Forster J Deichmann KA Common polymorphisms in the CTLA-4 and CD28 genes at 2q33 are not associated with asthma or atopy Eur J Immunogenet 2000 27 57 61 10792419 

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