$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Thrombin down‐regulates the TGF‐β‐mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR‐dependent activation of PAR‐1 원문보기

Journal of cellular physiology, v.225 no.1, 2010년, pp.233 - 239  

Bae, Jong‐Sup (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea) ,  Kim, In‐San ,  Rezaie, Alireza R.

Abstract AI-Helper 아이콘AI-Helper

AbstractHuman proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammat...

참고문헌 (49)

  1. Bae JS , Rezaie AR . 2008 . Protease activated receptor 1 (PAR‐1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand . Thromb Haemost 100 : 101 – 109 . 

  2. Bae JS , Rezaie AR . 2009 . Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine‐stimulated vascular endothelial cells when EPCR is occupied by protein C . Thromb Haemost 101 : 513 – 520 . 

  3. Bae JS , Yang L , Manithody C , Rezaie AR . 2007a . The ligand occupancy of endothelial protein C receptor switches the protease‐activated receptor 1‐dependent signaling specificity of thrombin from a permeability‐enhancing to a barrier‐protective response in endothelial cells . Blood 110 : 3909 – 3916 . 

  4. Bae JS , Yang L , Rezaie AR . 2007b . Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells . Proc Natl Acad Sci USA 104 : 2867 – 2872 . 

  5. Bae JS , Kim YU , Park MK , Rezaie AR . 2009 . Concentration dependent dual effect of thrombin in endothelial cells via Par‐1 and Pi3 Kinase . J Cell Physiol 219 : 744 – 751 . 

  6. Bernard GR , Vincent JL , Laterre PF , LaRosa SP , Dhainaut JF , Lopez‐Rodriguez A , Steingrub JS , Garber GE , Helterbrand JD , Ely EW , Fisher CJ Jr. 2001 . Efficacy and safety of recombinant human activated protein C for severe sepsis . N Engl J Med 344 : 699 – 709 . 

  7. Bonventre JV , Zuk A . 2004 . Ischemic acute renal failure: An inflammatory disease? Kidney Int 66 : 480 – 485 . 

  8. Border WA . 1994 . Transforming growth factor‐beta and the pathogenesis of glomerular diseases . Curr Opin Nephrol Hypertens 3 : 54 – 58 . 

  9. Coughlin SR . 2005 . Protease‐activated receptors in hemostasis, thrombosis and vascular biology . J Thromb Haemost 3 : 1800 – 1814 . 

  10. Dahlback B , Villoutreix BO . 2005 . The anticoagulant protein C pathway . FEBS Lett 579 : 3310 – 3316 . 

  11. Du B , Ma LM , Huang MB , Zhou H , Huang HL , Shao P , Chen YQ , Qu LH . 2010 . High glucose down‐regulates miR‐29a to increase collagen IV production in HK‐2 cells . FEBS Lett 584 : 811 – 816 . 

  12. Esmon CT . 1993a . Cell mediated events that control blood coagulation and vascular injury . Annu Rev Cell Biol 9 : 1 – 26 . 

  13. Esmon CT . 1993b . Molecular events that control the protein C anticoagulant pathway . Thromb Haemost 70 : 29 – 35 . 

  14. Feistritzer C , Riewald M . 2005 . Endothelial barrier protection by activated protein C through PAR1‐dependent sphingosine 1‐phosphate receptor‐1 crossactivation . Blood 105 : 3178 – 3184 . 

  15. Finigan JH , Dudek SM , Singleton PA , Chiang ET , Jacobson JR , Camp SM , Ye SQ , Garcia JG . 2005 . Activated protein C mediates novel lung endothelial barrier enhancement: Role of sphingosine 1‐phosphate receptor transactivation . J Biol Chem 280 : 17286 – 17293 . 

  16. Flynn AN , Buret AG . 2004 . Proteinase‐activated receptor 1 (PAR‐1) and cell apoptosis . Apoptosis 9 : 729 – 737 . 

  17. Grand RJ , Turnell AS , Grabham PW . 1996 . Cellular consequences of thrombin‐receptor activation . Biochem J 313 : 353 – 368 . 

  18. Grandaliano G , Monno R , Ranieri E , Gesualdo L , Schena FP , Martino C , Ursi M . 2000 . Regenerative and proinflammatory effects of thrombin on human proximal tubular cells . J Am Soc Nephrol 11 : 1016 – 1025 . 

  19. Grandaliano G , Di Paolo S , Monno R , Stallone G , Ranieri E , Pontrelli P , Gesualdo L , Schena FP . 2001 . Protease‐activated receptor 1 and plasminogen activator inhibitor 1 expression in chronic allograft nephropathy: The role of coagulation and fibrinolysis in renal graft fibrosis . Transplantation 72 : 1437 – 1443 . 

  20. Gupta A , Berg DT , Gerlitz B , Sharma GR , Syed S , Richardson MA , Sandusky G , Heuer JG , Galbreath EJ , Grinnell BW . 2007 . Role of protein C in renal dysfunction after polymicrobial sepsis . J Am Soc Nephrol 18 : 860 – 867 . 

  21. Gupta A , Gerlitz B , Richardson MA , Bull C , Berg DT , Syed S , Galbreath EJ , Swanson BA , Jones BE , Grinnell BW . 2009 . Distinct functions of activated protein C differentially attenuate acute kidney injury . J Am Soc Nephrol 20 : 267 – 277 . 

  22. Huang YQ , Li JJ , Hu L , Lee M , Karpatkin S . 2001 . Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes . Thromb Haemost 86 : 1094 – 1098 . 

  23. Isermann B , Vinnikov IA , Madhusudhan T , Herzog S , Kashif M , Blautzik J , Corat MA , Zeier M , Blessing E , Oh J , Gerlitz B , Berg DT , Grinnell BW , Chavakis T , Esmon CT , Weiler H , Bierhaus A , Nawroth PP . 2007 . Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis . Nat Med 13 : 1349 – 1358 . 

  24. Iwata M , Herrington J , Zager RA . 1995 . Sphingosine: A mediator of acute renal tubular injury and subsequent cytoresistance . Proc Natl Acad Sci USA 92 : 8970 – 8974 . 

  25. Joyce DE , Gelbert L , Ciaccia A , DeHoff B , Grinnell BW . 2001 . Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis . J Biol Chem 276 : 11199 – 11203 . 

  26. Kaizuka M , Yamabe H , Osawa H , Okumura K , Fujimoto N . 1999 . Thrombin stimulates synthesis of type IV collagen and tissue inhibitor of metalloproteinases‐1 by cultured human mesangial cells . J Am Soc Nephrol 10 : 1516 – 1523 . 

  27. Kaplanski G , Marin V , Fabrigoule M , Boulay V , Benoliel AM , Bongrand P , Kaplanski S , Farnarier C . 1998 . Thrombin‐activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule‐1 (ICAM‐1; CD54) and vascular cell adhesion molecule‐1 (VCAM‐1; CD106) . Blood 92 : 1259 – 1267 . 

  28. Kerschen EJ , Fernandez JA , Cooley BC , Yang XV , Sood R , Mosnier LO , Castellino FJ , Mackman N , Griffin JH , Weiler H . 2007 . Endotoxemia and sepsis mortality reduction by non‐anticoagulant activated protein C . J Exp Med 204 : 2439 – 2448 . 

  29. Klahr S , Schreiner G , Ichikawa I . 1988 . The progression of renal disease . N Engl J Med 318 : 1657 – 1666 . 

  30. Laping NJ , Olson BA , Short B , Albrightson CR . 1997 . Thrombin increases clusterin mRNA in glomerular epithelial and mesangial cells . J Am Soc Nephrol 8 : 906 – 914 . 

  31. Li X , Hahn CN , Parsons M , Drew J , Vadas MA , Gamble JR . 2004 . Role of protein kinase Czeta in thrombin‐induced endothelial permeability changes: Inhibition by angiopoietin‐1 . Blood 104 : 1716 – 1724 . 

  32. Ludeman MJ , Kataoka H , Srinivasan Y , Esmon NL , Esmon CT , Coughlin SR . 2005 . PAR1 cleavage and signaling in response to activated protein C and thrombin . J Biol Chem 280 : 13122 – 13128 . 

  33. MacKay K , Striker LJ , Stauffer JW , Doi T , Agodoa LY , Striker GE . 1989 . Transforming growth factor‐beta. Murine glomerular receptors and responses of isolated glomerular cells . J Clin Invest 83 : 1160 – 1167 . 

  34. Mann KG , Jenny RJ , Krishnaswamy S . 1988 . Cofactor proteins in the assembly and expression of blood clotting enzyme complexes . Annu Rev Biochem 57 : 915 – 956 . 

  35. McLaughlin JN , Shen L , Holinstat M , Brooks JD , Dibenedetto E , Hamm HE . 2005 . Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease‐activated receptor‐1 . J Biol Chem 280 : 25048 – 25059 . 

  36. Molitoris BA , Sutton TA . 2004 . Endothelial injury and dysfunction: Role in the extension phase of acute renal failure . Kidney Int 66 : 496 – 499 . 

  37. Mosnier LO , Zlokovic BV , Griffin JH . 2007 . The cytoprotective protein C pathway . Blood 109 : 3161 – 3172 . 

  38. Nestoridi E , Kushak RI , Duguerre D , Grabowski EF , Ingelfinger JR . 2005 . Up‐regulation of tissue factor activity on human proximal tubular epithelial cells in response to Shiga toxin . Kidney Int 67 : 2254 – 2266 . 

  39. Nierodzik ML , Kajumo F , Karpatkin S . 1992 . Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo . Cancer Res 52 : 3267 – 3272 . 

  40. Olgemoller B , Schleicher E . 1993 . Alterations of glomerular matrix proteins in the pathogenesis of diabetic nephropathy . Clin Investig 71 : S13 – S19 . 

  41. Ruf W , Dorfleutner A , Riewald M . 2003 . Specificity of coagulation factor signaling . J Thromb Haemost 1 : 1495 – 1503 . 

  42. Ryan MJ , Johnson G , Kirk J , Fuerstenberg SM , Zager RA , Torok‐Storb B . 1994 . HK‐2: An immortalized proximal tubule epithelial cell line from normal adult human kidney . Kidney Int 45 : 48 – 57 . 

  43. Shirato K , Osawa H , Kaizuka M , Nakamura N , Sugawara T , Nakamura M , Tamura M , Yamabe H , Okumura K . 2003 . Thrombin stimulates production of fibronectin by human proximal tubular epithelial cells via a transforming growth factor‐beta‐dependent mechanism . Nephrol Dial Transplant 18 : 2248 – 2254 . 

  44. Taylor FB , Kinasewitz G . 2004 . Activated protein C in sepsis . J Thromb Haemost 2 : 708 – 717 . 

  45. Tipping PG , Dowling JP , Holdsworth SR . 1988 . Glomerular procoagulant activity in human proliferative glomerulonephritis . J Clin Invest 81 : 119 – 125 . 

  46. Vesey DA , Cheung CW , Kruger WA , Poronnik P , Gobe G , Johnson DW . 2005 . Thrombin stimulates proinflammatory and proliferative responses in primary cultures of human proximal tubule cells . Kidney Int 67 : 1315 – 1329 . 

  47. Walker FJ , Fay PJ . 1992 . Regulation of blood coagulation by the protein C system . FASEB J 6 : 2561 – 2567 . 

  48. Wan L , Bellomo R , Di Giantomasso D , Ronco C . 2003 . The pathogenesis of septic acute renal failure . Curr Opin Crit Care 9 : 496 – 502 . 

  49. Xu Y , Zacharias U , Peraldi MN , He CJ , Lu C , Sraer JD , Brass LF , Rondeau E . 1995 . Constitutive expression and modulation of the functional thrombin receptor in the human kidney . Am J Pathol 146 : 101 – 110 . 

LOADING...
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로