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Abstract ▼ AI-Helper

Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chro...

Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chronic liver disease is not still cleared. To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the TGF-β1-induced hepatocyte apoptosis. Bee venom treatment inhibited the apopotic cell morphology and increased cell viability in TGF-β1-induced hepatocyte apoptosis. With TGF-β1 treatment, bee venom treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase-3 and Caspase-9. In conclusion, bee venom treatment in TGF-β1-mediated hepatocyte apoptosis occurred through the regulation of Bcl-family with subsequent inactivation of the Caspase. These results suggest that bee venom treatment may be of use in preventing the hepatocyte cell death in chronic liver disease.

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