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Biochemical and biophysical research communications, v.410 no.3, 2011년, pp.677 - 681
Ono, E. (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan) , Inoue, J. , Hashidume, T. , Shimizu, M. , Sato, R.
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TGR5 is a member of the G protein-coupled receptor family and is activated by bile acids (BAs). TGR5 is thought to be a promising drug target for metabolic diseases because the activation of TGR5 prevents obesity and hyperglycemia in mice fed a high-fat diet (HFD). In the present study, ...
Nature Zimmet 414 782 2001 10.1038/414782a Global and societal implications of the diabetes epidemic
Biochem. Biophys. Res. Commun. Maruyama 298 714 2002 10.1016/S0006-291X(02)02550-0 Identification of membrane-type receptor for bile acids (M-BAR)
J. Biol. Chem. Kawamata 278 9435 2003 10.1074/jbc.M209706200 A G protein-coupled receptor responsive to bile acids
Nature Watanabe 439 484 2006 10.1038/nature04330 Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Cell Metab. Thomas 10 167 2009 10.1016/j.cmet.2009.08.001 TGR5-mediated bile acid sensing controls glucose homeostasis
Drug Discov. Today Tiwari 14 523 2009 10.1016/j.drudis.2009.02.005 TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders
J. Med. Chem. Sato 51 1831 2008 10.1021/jm7015864 Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies
J. Med. Chem. Pellicciari 50 4265 2007 10.1021/jm070633p Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5
Mol. Pharmacol. Rizzo 78 617 2010 10.1124/mol.110.064501 Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist
J. Med. Chem. Pellicciari 52 7958 2009 10.1021/jm901390p Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
Biochem. Biophys. Res. Commun. Sato 362 793 2007 10.1016/j.bbrc.2007.06.130 Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
J. Med. Chem. Genet 53 178 2010 10.1021/jm900872z Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes
Chem. Med. Chem. Genet 5 1983 2010 10.1002/cmdc.201000329 Redefining the TGR5 triterpenoid binding pocket at the C-3 position
J. Agric. Food Chem. Hasegawa 28 922 1980 10.1021/jf60231a016 Limonoids in citrus seeds: origin and relative concentration
Food Rev. Int. Hasegawa 12 413 1996 10.1080/87559129609541089 Biochemistry and biological functions of citrus limonoids
Biol. Pharm. Bull. Roy 29 191 2006 10.1248/bpb.29.191 Limonoids: overview of significant bioactive triterpenes distributed in plants kingdom
J. Agric. Food Chem. Manners 55 8285 2007 10.1021/jf071797h Citrus limonoids: analysis, bioactivity, and biomedical prospects
J. Biol. Chem. Misawa 278 36176 2003 10.1074/jbc.M302387200 Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
J. Biol. Chem. Nakahara 280 42283 2005 10.1074/jbc.M507454200 Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine
J. Biol. Chem. Sato 274 24714 1999 10.1074/jbc.274.35.24714 Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription
Nature Lowell 404 652 2000 10.1038/35007527 Towards a molecular understanding of adaptive thermogenesis
FEBS Lett. Zhang 579 1446 2005 10.1016/j.febslet.2005.01.046 Free fatty acids increase PGC-1alpha expression in isolated rat islets
Diabetologia Staiger 48 2115 2005 10.1007/s00125-005-1895-z Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro
J. Biol. Chem. Tai 284 32239 2009 10.1074/jbc.M109.024661 Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism
J. Agric. Food Chem. Manners 51 4156 2003 10.1021/jf0300691 Bioavailability of citrus limonoids in humans
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