[논문]The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα

Shin, Soon Shik; Park, Dongmin; Lee, Hee Young; Hong, Yeonhee; Choi, Jeonghyun; Oh, Jaeho; Lee, Hyunghee; Lee, Hye Rim; Kim, Mi Ryeo; Shen, Zhi Bin; Cui, Hong Hua; Yoon, Michung

doi:10.3109/13880209.2011.618502

The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα 원문보기

Pharmaceutical biology, v.50 no.4, 2012년, pp.506 - 515

Shin, Soon Shik (Department of Formula Sciences, College of Oriental Medicine, Dongeui University, Busan 614-052) , Park, Dongmin (Department of Life Sciences, Mokwon University, Daejon 302-729) , Lee, Hee Young (Department of Formula Sciences, College of Oriental Medicine, Dongeui University, Busan 614-052) , Hong, Yeonhee (Department of Life Sciences, Mokwon University, Daejon 302-729) , Choi, Jeonghyun (Department of Life Sciences, Mokwon University, Daejon 302-729) , Oh, Jaeho (Department of Life Sciences, Mokwon University, Daejon 302-729) , Lee, Hyunghee (Department of Life Sciences, Mokwon University, Daejon 302-729) , Lee, Hye Rim (Department of Formula Sciences, College of Oriental Medicine, Dongeui University, Busan 614-052) , Kim, Mi Ryeo (R&D Team for New Drug of Oriental Medicine (BK 21), Department of Pharmacology, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Korea) , Shen, Zhi Bin (Department of Chemistry and Analysis of Traditional Chinese Medicine, College of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangdong, China) , Cui, Hong Hua (Department of Chemistry and Analysis of Traditional Chinese Med) , Yoon, Michung

Abstract ▼ AI-Helper

Context: Since AMP-activated protein kinase (AMPK) activation in skeletal muscle of obese rodents stimulates fatty acid oxidation, it is reasonable to hypothesize that pharmacological activation of AMPK might be of therapeutic benefit in obesity.Objective: To investigate the effects of the traditional Korean anti-obesity drug GGEx18, a mixture of three herbs, Laminaria japonica Aresch (Laminariaceae), Rheum palmatum L. (Polygonaceae), and Ephedra sinica Stapf (Ephedraceae), on obesity and the involvement of AMPK in this process.Materials and methods: After high fat diet-induced obese mice were treated with GGEx18, we studied the effects of GGEx18 on body weight, fat mass, skeletal muscle lipid accumulation, and the expressions of AMPK, peroxisome proliferator-activated receptor &aacgr;郭 (PPARα), and PPARα target genes. The effects of GGEx18 and/or the AMPK inhibitor compound C on lipid accumulation and expression of the above genes were measured in C2C12 skeletal muscle cells.Results: Administration of GGEx18 to obese mice for 9 weeks significantly (p < 0.05) decreased body and adipose tissue weights compared with obese control mice (p < 0.05). Lipid accumulation in skeletal muscle was inhibited by GGEx18. GGEx18 significantly (p < 0.05) increased skeletal muscle mRNA levels of AMPKα1 and AMPKα2 as well as PPARα and its target genes. Consistent with the in vivo data, GGEx18 inhibited lipid accumulation, and similar activation of genes was observed in GGEx18-treated C2C12 cells. However, compound C inhibited these effects in C2C12 cells.Discussion and conclusion: These results suggest that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation.

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참고문헌 (35)

J Food Sci Ahn IS 31 11 2006
J Biol Chem Aoyama T 5678 273 1998 10.1074/jbc.273.10.5678

상세보기
Int J Obes Relat Metab Disord Boozer CN 593 26 2002 10.1038/sj.ijo.0802023

상세보기
Int J Obes Relat Metab Disord Boozer CN 316 25 2001 10.1038/sj.ijo.0801539

상세보기
Trends Biochem Sci Carling D 18 29 2004 10.1016/j.tibs.2003.11.005

상세보기
J Clin Invest Colberg SR 1846 95 1995 10.1172/JCI117864

상세보기
Am J Physiol Endocrinol Metab Collier CA E182 291 2006 10.1152/ajpendo.00272.2005

상세보기
Expert Opin Drug Saf Fleming RM 749 7 2008 10.1517/14740330802510915

상세보기
Biol Pharm Bull Gao Y 1716 31 2008 10.1248/bpb.31.1716

상세보기
N Engl J Med Haller CA 1833 343 2000 10.1056/NEJM200012213432502

상세보기
Int J Obes (Lond) Hardie DG S7 32 4 2008 10.1038/ijo.2008.116

상세보기
Annu Rev Biochem Hardie DG 821 67 1998 10.1146/annurev.biochem.67.1.821

상세보기
J Physiol (Lond) Hardie DG 7 574 2006 10.1113/jphysiol.2006.108944

상세보기
Pharm Biol Huang L 422 48 2010 10.3109/13880200903150435

상세보기
Metab Clin Exp Jeong S 1284 53 2004 10.1016/j.metabol.2004.05.003

상세보기
Trends Biochem Sci Kemp BE 22 24 1999 10.1016/S0968-0004(98)01340-1

상세보기
Kroetz, Deanna L., Yook, Philip, Costet, Phillipe, Bianchi, Pascale, Pineau, Thierry. Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes. The Journal of biological chemistry, vol.273, no.47, 31581-31589.

상세보기
Biochem Biophys Res Commun Lee WJ 291 340 2006 10.1016/j.bbrc.2005.12.011

상세보기
Proc Natl Acad Sci USA Lee Y 11848 99 2002 10.1073/pnas.182420899

상세보기
Phytother Res Liu JF 588 25 2011 10.1002/ptr.3305

상세보기
Long, Y. C., Zierath, J. R.. AMP-activated protein kinase signaling in metabolic regulation. The Journal of clinical investigation, vol.116, no.7, 1776-1783.

상세보기
López-Soriano, Joaquín, Chiellini, Chiara, Maffei, Margherita, Grimaldi, Paul A., Argilés, Josep M.. Roles of Skeletal Muscle and Peroxisome Proliferator-Activated Receptors in the Development and Treatment of Obesity. Endocrine reviews, vol.27, no.3, 318-329.

상세보기
Pan, D A, Lillioja, S, Kriketos, A D, Milner, M R, Baur, L A, Bogardus, C, Jenkins, A B, Storlien, L H. Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action. Diabetes, vol.46, no.6, 983-988.

상세보기
FASEB J Simoneau JA 2051 13 1999 10.1096/fasebj.13.14.2051

상세보기
Suzuki, Atsushi, Okamoto, Shiki, Lee, Suni, Saito, Kumiko, Shiuchi, Tetsuya, Minokoshi, Yasuhiko. Leptin Stimulates Fatty Acid Oxidation and Peroxisome Proliferator-Activated Receptor α Gene Expression in Mouse C2C12 Myoblasts by Changing the Subcellular Localization of the α2 Form of AMP-Activated Protein Kinase. Molecular and cellular biology, vol.27, no.12, 4317-4327.

상세보기
J Physiol (Lond) Xue B 73 574 2006 10.1113/jphysiol.2006.113217

상세보기
Fitoterapia Xue J 173 81 2010 10.1016/j.fitote.2009.08.020

상세보기
J Biol Chem Yan ZH 10948 273 1998 10.1074/jbc.273.18.10948

상세보기
Pharmacol Res Yoon M 151 60 2009 10.1016/j.phrs.2009.02.004

상세보기
PPAR Res Yoon M 2010
Kor J Herbology Yoon KH 1 25 2010
Nutr Res Pract You JS 307 3 2009 10.4162/nrp.2009.3.4.307

원문보기 상세보기
Expert Opin Investig Drugs Zarain-Herzberg A 345 11 2002 10.1517/13543784.11.3.345

상세보기
J Chin Med Assoc Zheng CD 319 73 2010 10.1016/S1726-4901(10)70068-X

상세보기
J Clin Invest Zhou G 1167 108 2001 10.1172/JCI13505

상세보기

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The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα 원문보기

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The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα 원문보기

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