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Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury 원문보기

Nature communications, v.3, 2012년, pp.849 -   

Campbell, Matthew (1] Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland. [2]) ,  Hanrahan, Finnian (1] Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland. [2]) ,  Gobbo, Oliviero L. (School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.) ,  Kelly, Michael E. (FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.) ,  Kiang, Anna-Sophia (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.) ,  Humphries, Marian M. (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.) ,  Nguyen, Anh T.H. (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.) ,  Ozaki, Ema (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.) ,  Keaney, James (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.) ,  Blau, Christoph W. (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.) ,  Kerskens, Christian M. (Trinity College Institute of Neuroscience, Lloyd building, Trinity College Dublin, Dublin 2, Ireland.) ,  Cahalan, Stephen D. (UCD School of Veterinary Medicine & Con) ,  Callanan, John J. ,  Wallace, Eugene ,  Grant, Gerald A. ,  Doherty, Colin P. ,  Humphries, Peter

Abstract AI-Helper 아이콘AI-Helper

Traumatic brain injury is the leading cause of death in children and young adults globally. Malignant cerebral oedema has a major role in the pathophysiology that evolves after severe traumatic brain injury. Added to this is the significant morbidity and mortality from cerebral oedema associated wit...

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