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NTIS 바로가기Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, v.23 no.7, 2012년, pp.667 - 673
AbstractBackgroundThere have been considerable disagreements regarding the therapeutic effects of probiotics in atopic dermatitis (AD). We performed this study to examine whether the oral administration of Lactobacillus plantarum CJLP133 improves pediatric AD.MethodsIn a randomized, double‐blind, placebo‐controlled study, either L.?plantarum CJLP133 at a dosage of 0.5?×?1010?colony‐forming units or placebo in children aged 12?months to 13?yr was given twice a day for 12?wk. SCOring of Atopic Dermatitis (SCORAD) scores, eosinophil counts, serum total IgE, and cytokines were evaluated.ResultsForty‐four of 58 patients in the probiotic group and 39 of 60 patients in the placebo group completed the study. The SCORAD score at week 14 was lower in the probiotic group than in the placebo group (p?=?0.044). The mean change in the SCORAD score from weeks 2 to 14 was 9.1 in the probiotic group, which was greater than the mean change of 1.8 in the placebo group (p?=?0.004). No statistical differences in the total use of topical corticosteroids were found between two groups (p?=?0.815). In the probiotic group, the total eosinophil count was significantly lower at the end of the intervention compared to the baseline measurements (p?=?0.023). Logarithmic IFN‐γ and IL‐4 were significantly decreased by the end of the intervention compared to baseline measurements in the probiotic group (p?<?0.001 and 0.049).ConclusionsOur results suggest that supplementation with probiotic L.?plantarum CJLP133 is beneficial in the treatment of pediatric AD.
van der Aa LB , Heymans HS , van Aalderen WM , Sprikkelman AB . Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence . Pediatr Allergy Immunol 2010 : 21 : e355 – 67 .
Pan SJ , Kuo CH , Lam KP , Chu YT , Wang WL , Hung CH . Probiotics and allergy in children–an update review . Pediatr Allergy Immunol 2010 : 21 : e659 – 66 .
Lewis MC , Inman CF , Patel D , et?al. Direct experimental evidence that early‐life farm environment influences regulation of immune responses . Pediatr Allergy Immunol 2012 : 23 : 265 – 9 .
Bjorksten B . Environment and infant immunity . Proc Nutr Soc 1999 : 58 : 729 – 32 .
Kirjavainen PV , Gibson GR . Healthy gut microflora and allergy: factors influencing development of the microbiota . Ann Med 1999 : 31 : 288 – 92 .
Ismail IH , Oppedisano F , Joseph SJ , Boyle RJ , Robins‐Browne RM , Tang ML . Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiota . Pediatr Allergy Immunol 2012 : 23 : 255 – 8 .
Weston S , Halbert A , Richmond P , Prescott SL . Effects of probiotics on atopic dermatitis: a randomised controlled trial . Arch Dis Child 2005 : 90 : 892 – 7 .
Gerasimov SV , Vasjuta VV , Myhovych OO , Bondarchuk LI . Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double‐blind, placebo‐controlled, clinical trial . Am J Clin Dermatol 2010 : 11 : 351 – 61 .
Woo SI , Kim JY , Lee YJ , Kim NS , Hahn YS . Effect of Lactobacillus sakei supplementation in children with atopic eczema‐dermatitis syndrome . Ann Allergy Asthma Immunol 2010 : 104 : 343 – 8 .
Brouwer ML , Wolt‐Plompen SA , Dubois AE , et?al. No effects of probiotics on atopic dermatitis in infancy: a randomized placebo‐controlled trial . Clin Exp Allergy 2006 : 36 : 899 – 906 .
Gruber C , Wendt M , Sulser C , et?al. Randomized, placebo‐controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy . Allergy 2007 : 62 : 1270 – 6 .
Kim JY , Kwon JH , Ahn SH , et?al. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double‐blind, randomized, placebo‐controlled trial . Pediatr Allergy Immunol 2010 : 21 : e386 – 93 .
Passeron T , Lacour JP , Fontas E , Ortonne JP . Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2?years . Allergy 2006 : 61 : 431 – 7 .
Won TJ , Kim B , Lim YT , et?al. Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC/Nga mice . J Appl Microbiol 2011 : 110 : 1195 – 202 .
Kang H , Oh YJ , Ahn KS , et?al. Leuconostoc citreum HJ‐P4 (KACC 91035) regulates immunoglobulin E in an ovalbumin‐induced allergy model and induces interleukin‐12 through nuclear factor‐kappa B and p38/c‐Jun N‐terminal kinases signaling in macrophages . Microbiol Immunol 2009 : 53 : 331 – 9 .
Lee J , Yun HS , Cho KW , et?al. Evaluation of probiotic characteristics of newly isolated Lactobacillus spp.: immune modulation and longevity . Int J Food Microbiol 2011 : 148 : 80 – 6 .
Hanifin JM , Rajka G . Diagnostic features of atopic dermatitis . Acta Derm Venereol (Stockh) 1980 : 1980 : 44 – 7 .
Severity scoring of atopic dermatitis: the SCORAD index . Consensus report of the European Task Force on Atopic Dermatitis . Dermatology 1993 : 186 : 23 – 31 .
Martinez FD , Holt PG . Role of microbial burden in aetiology of allergy and asthma . Lancet 1999 : 354 ( Suppl 2 ): SII12 – 5 .
Yao TC , Chang CJ , Hsu YH , Huang JL . Probiotics for allergic diseases: realities and myths . Pediatr Allergy Immunol 2010 : 21 : 900 – 19 .
Singh M , Ranjan Das R . Probiotics for allergic respiratory diseases–putting it into perspective . Pediatr Allergy Immunol 2010 : 21 : e368 – 76 .
Wu KG , Li TH , Chen CJ , Cheng HI , Wang TY . Correlations of serum Interleukin‐16, total IgE, eosinophil cationic protein and total eosinophil counts with disease activity in children with atopic dermatitis . Int J Immunopathol Pharmacol 2011 : 24 : 15 – 23 .
Trautmann A , Akdis M , Kleemann D , et?al. T cell‐mediated Fas‐induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis . J Clin Invest 2000 : 106 : 25 – 35 .
Novak N , Leung DY . Advances in atopic dermatitis . Curr Opin Immunol 2011 : 23 : 778 – 83 .
Akdis CA , Akdis M , Bieber T , et?al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report . Allergy 2006 : 61 : 969 – 87 .
Bieber T . Atopic dermatitis . N Engl J Med 2008 : 358 : 1483 – 94 .
Smits HH , Engering A , van der Kleij D , et?al. Selective probiotic bacteria induce IL‐10‐producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell‐specific intercellular adhesion molecule 3‐grabbing nonintegrin . J Allergy Clin Immunol 2005 : 115 : 1260 – 7 .
Rautava S , Kalliomaki M , Isolauri E . Probiotics during pregnancy and breast‐feeding might confer immunomodulatory protection against atopic disease in the infant . J Allergy Clin Immunol 2002 : 109 : 119 – 21 .
Hoarau C , Lagaraine C , Martin L , Velge‐Roussel F , Lebranchu Y . Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll‐like receptor 2 pathway . J Allergy Clin Immunol 2006 : 117 : 696 – 702 .
Kwon HK , Lee CG , So JS , et?al. Generation of regulatory dendritic cells and CD4+?Foxp3+ T cells by probiotics administration suppresses immune disorders . Proc Natl Acad Sci USA 2010 : 107 : 2159 – 64 .
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