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NTIS 바로가기British journal of clinical pharmacology, v.75 no.1, 2013년, pp.244 - 253
Jiang, Fen (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Desta, Zeruesenay (Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA) , Shon, Ji‐Hong (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Yeo, Chang‐Woo (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Kim, Ho‐Sook (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Liu, Kwang‐Hyeon (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Bae, Soo‐Kyung (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Lee, Sang‐Seop (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) , Flockhart, David A. (Division of Clinical) , Shin, Jae‐Gook
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Cytochrome P450 (CYP) 2B6 is the enzyme primarily responsible for the metabolism of many clinically important drugs, including efavirenz, which it converts to 8‐hydroxyefavirenz and then to 8,14‐hydroxyefavirenz.• The CYP2B6*6...
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