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NTIS 바로가기Apoptosis : an international journal on programmed cell death, v.18 no.4, 2013년, pp.509 - 520
Jeong, Ju-yeon (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea) , Kim, Kyung-Sul (Department of Biomedical Science, CHA University, Seoul, South Korea) , Moon, Ji-Sook (Department of Biomedical Science, CHA University, Seoul, South Korea) , Song, Ji-ae (Institute for Clinical Research, CHA University, Sungnam, South Korea) , Choi, Sung-ho (Isu Abxis Co., Ltd, Seoul, South Korea) , Kim, Kwang-il (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea) , Kim, Tae-Heon (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea) , An, Hee-Jung (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea)
The phosphatidylinositol 3-kinase (PI3K) pathway is one of the critical signaling cascades playing important roles in the chemoresistance of human cancer cells, including ovarian cancer. In this study, we investigated the potential of targeting the PI3K p110β-isoform as a novel approach to over...
1. Ozols RF Bundy BN Greer BE Fowler JM Clarke-Pearson D Burger RA Mannel RS DeGeest K Hartenbach EM Baergen R Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study J Clin Oncol Off J Am Soc Clin Oncol 2003 21 17 3194 3200 10.1200/JCO.2003.02.153
2. Bookman MA Brady MF McGuire WP Harper PG Alberts DS Friedlander M Colombo N Fowler JM Argenta PA De Geest K Mutch DG Burger RA Swart AM Trimble EL Accario-Winslow C Roth LM Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a phase III trial of the Gynecologic Cancer Intergroup J Clin Oncol Off J Am Soc Clin Oncol 2009 27 9 1419 1425 10.1200/JCO.2008.19.1684
3. Marupudi NI Han JE Li KW Renard VM Tyler BM Brem H Paclitaxel: a review of adverse toxicities and novel delivery strategies Expert Opin Drug Saf 2007 6 5 609 621 10.1517/14740338.6.5.609 17877447
4. Stordal B Pavlakis N Davey R A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship Cancer Treat Rev 2007 33 8 688 703 10.1016/j.ctrv.2007.07.013 17881133
5. McCubrey JA Steelman LS Abrams SL Lee JT Chang F Bertrand FE Navolanic PM Terrian DM Franklin RA D’Assoro AB Salisbury JL Mazzarino MC Stivala F Libra M Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance Adv Enzyme Regul 2006 46 249 279 10.1016/j.advenzreg.2006.01.004 16854453
6. Yu HG Ai YW Yu LL Zhou XD Liu J Li JH Xu XM Liu S Chen J Liu F Qi YL Deng Q Cao J Liu SQ Luo HS Yu JP Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death Int J Cancer 2008 122 2 433 443 10.1002/ijc.23049 17935137
7. Cantley LC The phosphoinositide 3-kinase pathway Science 2002 296 5573 1655 1657 10.1126/science.296.5573.1655 12040186
8. Rameh LE Cantley LC The role of phosphoinositide 3-kinase lipid products in cell function J Biol Chem 1999 274 13 8347 8350 10.1074/jbc.274.13.8347 10085060
9. Shayesteh L Lu Y Kuo WL Baldocchi R Godfrey T Collins C Pinkel D Powell B Mills GB Gray JW PIK3CA is implicated as an oncogene in ovarian cancer Nat Genet 1999 21 1 99 102 10.1038/5042 9916799
10. Kang S Bader AG Vogt PK Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic Proc Natl Acad Sci USA 2005 102 3 802 807 10.1073/pnas.0408864102 15647370
11. Campbell IG Russell SE Choong DY Montgomery KG Ciavarella ML Hooi CS Cristiano BE Pearson RB Phillips WA Mutation of the PIK3CA gene in ovarian and breast cancer Cancer Res 2004 64 21 7678 7681 10.1158/0008-5472.CAN-04-2933 15520168
12. Levine DA Bogomolniy F Yee CJ Lash A Barakat RR Borgen PI Boyd J Frequent mutation of the PIK3CA gene in ovarian and breast cancers Clin Cancer Res 2005 11 8 2875 2878 10.1158/1078-0432.CCR-04-2142 15837735
13. Westfall SD Skinner MK Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment Mol Cancer Ther 2005 4 11 1764 1771 10.1158/1535-7163.MCT-05-0192 16275998
14. Fraser M Bai T Tsang BK Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function Int J Cancer 2008 122 3 534 546 10.1002/ijc.23086 17918180
15. Hu L Hofmann J Lu Y Mills GB Jaffe RB Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models Cancer Res 2002 62 4 1087 1092 11861387
16. Jamieson S Flanagan JU Kolekar S Buchanan C Kendall JD Lee WJ Rewcastle GW Denny WA Singh R Dickson J Baguley BC Shepherd PR A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types Biochem J 2011 438 1 53 62 10.1042/BJ20110502 21668414
17. Liu P Cheng H Roberts TM Zhao JJ Targeting the phosphoinositide 3-kinase pathway in cancer Nat Rev Drug Discov 2009 8 8 627 644 10.1038/nrd2926 19644473
18. An HJ Cho NH Yang HS Kwak KB Kim NK Oh DY Lee SW Kim HO Koh JJ Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells J Pathol 2007 212 2 161 169 10.1002/path.2158 17427168
19. Engelman JA Luo J Cantley LC The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nat Rev Genet 2006 7 8 606 619 10.1038/nrg1879 16847462
20. Katso R Okkenhaug K Ahmadi K White S Timms J Waterfield MD Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer Annu Rev Cell Dev Biol 2001 17 615 675 10.1146/annurev.cellbio.17.1.615 11687500
21. Liu SQ Yu JP Yu HG Lv P Chen HL Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells Dig Liver Dis 2006 38 5 310 318 10.1016/j.dld.2006.01.012 16527552
22. Winograd-Katz SE Levitzki A Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor Oncogene 2006 25 56 7381 7390 10.1038/sj.onc.1209737 16785992
23. Ciraolo E Iezzi M Marone R Marengo S Curcio C Costa C Azzolino O Gonella C Rubinetto C Wu H Dastru W Martin EL Silengo L Altruda F Turco E Lanzetti L Musiani P Ruckle T Rommel C Backer JM Forni G Wymann MP Hirsch E Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development Sci Signal 2008 1 36 ra3 10.1126/scisignal.1161577 18780892
24. Foukas LC Claret M Pearce W Okkenhaug K Meek S Peskett E Sancho S Smith AJ Withers DJ Vanhaesebroeck B Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation Nature 2006 441 7091 366 370 10.1038/nature04694 16625210
25. Vivanco I Sawyers CL The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2002 2 7 489 501 10.1038/nrc839 12094235
26. Zhang L Yang N Liang S Barchetti A Vezzani C Huang J O’Brien-Jenkins A Rubin SC Coukos G RNA interference: a potential strategy for isoform-specific phosphatidylinositol 3-kinase targeted therapy in ovarian cancer Cancer Biol Ther 2004 3 12 1283 1289 10.4161/cbt.3.12.1388 15662137
27. Jia S Liu Z Zhang S Liu P Zhang L Lee SH Zhang J Signoretti S Loda M Roberts TM Zhao JJ Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis Nature 2008 454 7205 776 779 18594509
28. Gupta S Ramjaun AR Haiko P Wang Y Warne PH Nicke B Nye E Stamp G Alitalo K Downward J Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice Cell 2007 129 5 957 968 10.1016/j.cell.2007.03.051 17540175
29. Guerreiro AS Fattet S Fischer B Shalaby T Jackson SP Schoenwaelder SM Grotzer MA Delattre O Arcaro A Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration Clin Cancer Res 2008 14 21 6761 6769 10.1158/1078-0432.CCR-08-0385 18980969
30. Wee S Wiederschain D Maira SM Loo A Miller C deBeaumont R Stegmeier F Yao YM Lengauer C PTEN-deficient cancers depend on PIK3CB Proc Natl Acad Sci USA 2008 105 35 13057 13062 10.1073/pnas.0802655105 18755892
31. Gao N Flynn DC Zhang Z Zhong XS Walker V Liu KJ Shi X Jiang BH G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells Am J Physiol Cell Physiol 2004 287 2 C281 C291 10.1152/ajpcell.00422.2003 15028555
32. McDonald GT Sullivan R Pare GC Graham CH Inhibition of phosphatidylinositol 3-kinase promotes tumor cell resistance to chemotherapeutic agents via a mechanism involving delay in cell cycle progression Exp Cell Res 2010 316 19 3197 3206 10.1016/j.yexcr.2010.08.007 20736003
33. Jiang BH Liu LZ PI3K/PTEN signaling in tumorigenesis and angiogenesis Biochim Biophys Acta 2008 1784 1 150 158 10.1016/j.bbapap.2007.09.008 17964232
34. Andreu EJ Lledo E Poch E Ivorra C Albero MP Martinez-Climent JA Montiel-Duarte C Rifon J Perez-Calvo J Arbona C Prosper F Perez-Roger I BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells Cancer Res 2005 65 8 3264 3272 15833859
35. Luque I Gelinas C Rel/NF-κB and I κB factors in oncogenesis Semin Cancer Biol 1997 8 2 103 111 10.1006/scbi.1997.0061 9299588
37. Wang CY Mayo MW Korneluk RG Goeddel DV Baldwin AS Jr NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation Science 1998 281 5383 1680 1683 10.1126/science.281.5383.1680 9733516
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