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Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers 원문보기

Apoptosis : an international journal on programmed cell death, v.18 no.4, 2013년, pp.509 - 520  

Jeong, Ju-yeon (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea) ,  Kim, Kyung-Sul (Department of Biomedical Science, CHA University, Seoul, South Korea) ,  Moon, Ji-Sook (Department of Biomedical Science, CHA University, Seoul, South Korea) ,  Song, Ji-ae (Institute for Clinical Research, CHA University, Sungnam, South Korea) ,  Choi, Sung-ho (Isu Abxis Co., Ltd, Seoul, South Korea) ,  Kim, Kwang-il (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea) ,  Kim, Tae-Heon (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea) ,  An, Hee-Jung (Department of Pathology, College of Medicine, CHA University, 351 Yatap-dong, Gyeonggi-Do Seongnam Si Bundang-gu, 463-712 Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

The phosphatidylinositol 3-kinase (PI3K) pathway is one of the critical signaling cascades playing important roles in the chemoresistance of human cancer cells, including ovarian cancer. In this study, we investigated the potential of targeting the PI3K p110β-isoform as a novel approach to over...

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참고문헌 (37)

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