[논문]Amomum villosum induces longitudinal bone growth in adolescent female rats

Lee, S.H.; Kim, J.Y.; Kim, H.; Park, S.K.; Kim, C.Y.; Chung, S.Y.; Chang, G.T.

doi:10.1016/S0254-6272(13)60054-0

[해외논문] Amomum villosum induces longitudinal bone growth in adolescent female rats 원문보기

Journal of traditional Chinese medicine = 中醫雜誌, v.32 no.3, 2012년, pp.453 - 458

Lee, S.H. , Kim, J.Y. , Kim, H. , Park, S.K. , Kim, C.Y. , Chung, S.Y. , Chang, G.T.

Abstract ▼ AI-Helper

Objective: This study was conducted to evaluate the effect of Amomum villosum on longitudinal bone growth. Methods: Adolescent female Sprague-Dawley rats were divided into 3 groups and treated for 4 days: control (distilled water, p.o.), recombinant human growth hormone (rhGH; 100 μg/kg, s.c.), and A. villosum (500 mg/kg, p.o.) groups. On day 3, tetracycline (20 g/kg, i.p.) was injected for growth plate identification. On days 2, 3 and 4, 5-bromo-2'-deoxyuridine (BrdU) (50 mg/kg, i.p.) was injected to label proliferating cells. On day 5, tibias were dissected and fixed in 4% paraformaldehyde, dehydrated, and sectioned for immunohistochemistry and histomorphometry. Results: The rate of bone growth in the A. villosum and rhGH groups increased to (410 +/- 44) and (389 +/- 46) μm/day (P<0.01), respectively, as compared with the control (330.7 +/- 34.7) μm/day. The thickness of the growth plates also increased to (591 +/- 37) and (598 +/- 32) μm, respectively, as compared with the control (524+/-89) μm (P<0.001). The number of BrdU-positive cells in the chondrocytes of the A. villosum and rhGH groups was also significantly higher (126+/-24) and (143+/-18) cells/mm2, respectively) than in the control (109 +/- 25) mm2 (P<0.05). Insulin-like growth factor-1 and bone morphogenetic protein-2 in the A. villosum and rhGH groups were highly expressed in the growth plate as compared with the control samples, indicating increased bone formation. Conclusions: A. villosum could be used to treat growth retardation during adolescence.

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참고문헌 (22)

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[해외논문] Amomum villosum induces longitudinal bone growth in adolescent female rats 원문보기

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