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Yonsei medical journal, v.54 no.4, 2013년, pp.854 - 864
Jung, Minkyu (Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) , Lee, Chul Ho (Department of Clinical Genetics, Yonsei University College of Medicine, Seoul, Korea.) , Park, Hyung Soon (Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.) , Lee, Ji Hyun (Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.) , Kang, Young Ae (Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) , Kim, Se Kyu (Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) , Chang, Joon (Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) , Kim, Dae Joon (Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea.) , Rha, Sun Young (Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) , Kim, Joo Hang (Division of Medical Oncology, Department of Internal Medicine, Yo) , Cho, Byoung Chul
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PurposeThe main objective of this study was to evaluate the association between polymorphisms of the target genes of pemetrexed and clinical outcomes in non-small cell lung cancer (NSCLC) patients treated with pemetrexed.Materials and MethodsWe assessed polymorphisms at 8 sites in 4 genes [thymidyla...
1 Curtin NJ Hughes AN Pemetrexed disodium, a novel antifolate with multiple targets Lancet Oncol 2001 2 298 306 11905785
2 Adjei AA Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent Clin Cancer Res 2004 10 12 Pt 2 4276s 4280s 15217974
3 Kaneda S Nalbantoglu J Takeishi K Shimizu K Gotoh O Seno T Structural and functional analysis of the human thymidylate synthase gene J Biol Chem 1990 265 20277 20284 2243092
4 Jakobsen A Nielsen JN Gyldenkerne N Lindeberg J Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity J Clin Oncol 2005 23 1365 1369 15735113
5 Dervieux T Furst D Lein DO Capps R Smith K Walsh M Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis Arthritis Rheum 2004 50 2766 2774 15457444
6 Berkun Y Levartovsky D Rubinow A Orbach H Aamar S Grenader T Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene Ann Rheum Dis 2004 63 1227 1231 15361376
7 Schultz RM Chen VJ Bewley JR Roberts EF Shih C Dempsey JA Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs Semin Oncol 1999 26 2 Suppl 6 68 73 10598558
8 Sigmond J Backus HH Wouters D Temmink OH Jansen G Peters GJ Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression Biochem Pharmacol 2003 66 431 438 12907242
9 Smit EF Burgers SA Biesma B Smit HJ Eppinga P Dingemans AM Randomized phase II and pharmacogenetic study of pemetrexed compared with pemetrexed plus carboplatin in pretreated patients with advanced non-small-cell lung cancer J Clin Oncol 2009 27 2038 2045 19307503
10 Ulrich CM Robien K Sparks R Pharmacogenetics and folate metabolism--a promising direction Pharmacogenomics 2002 3 299 313 12052139
11 Travis WD Colby TV Corrin B Shimosato Y Brambilla E Histological typing of lung and pleural tumours 1999 3rd ed Berlin Springer-Verlag
12 Therasse P Arbuck SG Eisenhauer EA Wanders J Kaplan RS Rubinstein L European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada New guidelines to evaluate the response to treatment in solid tumors J Natl Cancer Inst 2000 92 205 216 10655437
13 Boom R Sol CJ Salimans MM Jansen CL Wertheim-van Dillen PM van der Noordaa J Rapid and simple method for purification of nucleic acids J Clin Microbiol 1990 28 495 503 1691208
14 Nief N Le Morvan V Robert J Involvement of gene polymorphisms of thymidylate synthase in gene expression, protein activity and anticancer drug cytotoxicity using the NCI-60 panel Eur J Cancer 2007 43 955 962 17317154
15 Ceppi P Volante M Saviozzi S Rapa I Novello S Cambieri A Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase Cancer 2006 107 1589 1596 16955506
16 Scagliotti GV Parikh P von Pawel J Biesma B Vansteenkiste J Manegold C Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer J Clin Oncol 2008 26 3543 3551 18506025
17 Dulucq S St-Onge G Gagné V Ansari M Sinnett D Labuda D DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL Blood 2008 111 3692 3700 18096764
18 Wu MF Hsiao YM Huang CF Huang YH Yang WJ Chan HW Genetic determinants of pemetrexed responsiveness and nonresponsiveness in non-small cell lung cancer cells J Thorac Oncol 2010 5 1143 1151 20559153
19 Uramoto H Onitsuka T Shimokawa H Hanagiri T TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed Anticancer Res 2010 30 4309 4315 21036757
20 Graziano F Kawakami K Ruzzo A Watanabe G Santini D Pizzagalli F Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population Int J Cancer 2006 118 628 632 16094648
21 Shannon B Gnanasampanthan S Beilby J Iacopetta B A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability Gut 2002 50 520 524 11889073
22 Boccia S Boffetta P Brennan P Ricciardi G Gianfagna F Matsuo K Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer Cancer Lett 2009 273 55 61 18789576
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