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NTIS 바로가기Photochemistry and photobiology, v.89 no.5, 2013년, pp.1216 - 1225
Kimura, Yoshiyuki (Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Toon City, Japan) , Sumiyoshi, Maho (Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Toon City, Japan) , Sakanaka, Masahiro (Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Toon City, Japan) , Taniguchi, Masahiko (Department of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki City, Japan) , Baba, Kimiye (Department of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki City, Japan)
AbstractWe examined the effects of six furocoumarins with alkoxy groups at the C‐5 or C‐8 position isolated from Umbelliferae medicinal plants on cell proliferation, and their mechanisms of action against B16F10 melanoma cells or in melanin‐possessing hairless mice implanted with B16F10 cells, under UVA irradiation. Three furocoumarins with an alkoxy group at C‐5, isoimperatorin (1), oxypeucedanin (2) and oxypeucedanin hydrate (3), showed antiproliferative activity and caused G2/M arrest at concentrations of 0.1–10.0?μm. Furthermore, three furocoumarins with an alkoxy group at C‐8, imperatorin (4), heraclenin (5) and heraclenol (6), inhibited the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1–1.0?μm. UVA plus 1, 2, 3, 4 and 6 reduced tumor growth and final tumor weight in B16F10‐bearing mice at a dose of 0.3, 0.5 or 1.0 mg?kg−1 (intraperitoneal injection). UVA plus 1, 3 and 6 increased Chk1 phosphorylation and reduced cdc2 (Thr 161) phosphorylation in melanoma cells. We suggest that the antitumor actions of UVA plus furocoumarins with an alkoxy group at C‐5 or C‐8 were due to G2/M arrest of the cell cycle by an increase in phosphor‐Chk1 and decrease in phospho‐cdc2.
Parrish , J. A. , T. B. Fitzpatrick , L. Tanenbaum and M. A. Pathak ( 1976 ) Photochemotherapy of psoriasis with oral methoxypsoralen and longwave ultraviolet light . N. Engl. J. Med. 291 , 1207 – 1211 .
Edelson , R. , C. Berger , F. Gasparro , B. Jegasothy , P. Heald , B. Wintrous , E. Vonderheid , R. Knobler , K. Wolff , G. Plewig , G. McKiernan , I. Christiansen , M. Oster , H. Honigsmann , H. Wilford , E. Kokoschka , T. Rehle , M. Perez , G. Stingl and L. Laroche ( 1987 ) Treatment of cutaneous T‐cell lymphoma by extracorporeal photochemotherapy . N. Engl. J. Med. 316 , 297 – 303 .
Malsawista , S. E. , D. Trock and R. L. Edelson ( 1991 ) Photopheresis for rheumatoid arthritis . Ann. N Y Acad. Sci. 636 , 217 – 226 .
Knobler , R. M. , W. Graninger , A. Lindmaier and F. Trautinger ( 1991 ) Photopheresis for the treatment of lupus erythematosus. Preliminary observations . Ann. N Y Acad. Sci. 636 , 340 – 356 .
Hearst , J. E. , S. T. Isaacs , D. Kanne , H. Rapoport and K. Straub ( 1984 ) The reaction of the psolarens with deoxyribobulceic acid . Q. Rev. Biophys. 17 , 1 – 44 .
Cimino , G. D. , H. B. Gamper , S. T. Isaacs and J. E. Hearst ( 1985 ) Psoralens are photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry . Ann. Rev. Biochem. 54 , 1151 – 1193 .
Borning , C. C. , T. S. Squire and T. Tony ( 1993 ) Cancer statistics1993 . CA Cancer J. Clin. 43 , 7 – 26 .
Miller , D. L. and M. A. Weinstock ( 1994 ) Nonmelanoma skin cancer in the United States: incidence . J. Am. Acad. Dermatol. 30 , 774 – 778 .
O'Shaughnessy , J. A. , G. J. Kellof , G. B. Gordon , A. J. Dannenberg , W. K. Hong , C. C. Fabian , C. C. Sigman , M. M. Bertagnolli , S. P. Stratton , L. Stephen , W. G. Nelson , F. L. Meyskens , D. S. Alberts , M. Follen , A. K. Rustgi , L. W. Papadimitrakopoulou , P. T. Scardino , A. F. Gazdar , L. W. Wattenberg , M. B. Sporn , W. A. Sakr , S. M. Lippman and D. D. Von Hoff ( 2002 ) Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development . Clin. Cancer Res. 8 , 314 – 346 .
Setlow , R. B. , E. Grist , K. Thompson and A. D. Woodhead ( 1993 ) Wavelengths effective in induction of malignant melanoma . Proc. Natl. Acad. Sci. U S A 90 , 6666 – 6670 .
Runger , T. M. ( 1999 ) Role of UVA in the pathogenesis of melanoma and non‐melanoma skin cancer. A short review . Photodermatol. Photoimmunol. Photomed. 15 , 212 – 216 .
Moan , J. , A. Dahlback and R. B. Setlow ( 1999 ) Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation . Photochem. Photobiol. 70 , 243 – 247 .
Wang , S. Q. , R. Setlow , M. Berwick , D. Polsky , A. A. Marghoob , A. W. Kopf and R. S. Bart ( 2002 ) The mutagenic effect of ultraviolet‐A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes . Photodermatol. Photoimmunol. Photomed. 18 , 287 – 293 .
Agar , N. S. , G. M. Halliday , R. S. Barnetson , H. N. Ananthaswamy , M. Wheeler and A. M. Jones ( 2004 ) The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations. A role for UVA in human skin carcinogenesis . Proc. Natl. Acad. Sci. U S A 101 , 4954 – 4959 .
Via , L. D. , O. Gia , S. M. Magno , L. Santana , M. Teijeira and E. Uriarte ( 1999 ) New tetracyclic analogs of photochemotherapeutic drigs 5‐MOP and 8‐MOP: synthesis interaction, and antiproliferative activity . J. Med. Chem. 42 , 4405 – 4413 .
Leite , V. C. , R. F. Santos , L. C. Chen and L. A. Guillo ( 2004 ) Psoralen derivatives and long wave ultraviolet irradiation are active in vitro against human melanoma cell line . J. Photochem. Photobiol. B: Biol. 76 , 49 – 53 .
Bartošová , J. , K. Kuželová , M. Pluskalová , I. Marinov , P. Halada and Z. Gašová ( 2006 ) UVA‐activated 8‐methoxypsoralen (PUVA) causes G 2 /M cell cycle arrest in Karpas 299 T‐Lymphoma cells . J. Photochem. Photobiol. B: Biol. 85 , 39 – 48 .
Viola , G. , D. Vedaldi , F. Dall'Acqua , E. Fortunato , G. Basso , N. Bianchi , C. Zuccato , M. Borgatti , I. Lampronti and R. Gambari ( 2008 ) Induction of γ‐globin mRNA, erythroid differentiation and apoptosis in UVA‐irradiated human erythroid cells in the presence of furocoumarin derivatives . Biochem. Pharmacol. 75 , 810 – 825 .
Toyooka , T. and Y. Ibuki ( 2009 ) Histone deacetylase inhibitor sodium butyrate enhances the cell killing effect of psoralen plus UVA by attenuating nucleoside excision repair . Cancer Res. 69 , 3492 – 3500 .
Tokura , Y. , N. Seo , H. Yagi and M. Takigawa ( 2001 ) Photoactivational cytokine‐modulatory action of 8‐methoxypsoralen plus ultraviolet A in lymphocytes, monocytes, and cutaneous T cell lymphoma cells . Ann. N Y Acad. Sci. 941 , 185 – 193 .
Shimizu , A. , J. Nishida , Y. Ueoka , K. Kato , T. Hachiya , Y. Kuriaki and N. Wake ( 1998 ) Cyclin G contributes to G 2 /M arrest of cells in response to DNA damage . Biochem. Biophys. Res. Commun. 242 , 529 – 533 .
Liu , A. , K. Yoshioka , V. Salerno and P. Hsieh ( 2008 ) The mismatch repair‐mediated cell cycle checkpoint response to fuluorodeoxyuridine . J. Cell. Biochem. 105 , 245 – 254 .
Kang , K. , S. B. Lee , J.‐H. Yoo and C. W. Nho ( 2011 ) Flow cytometric fluorescence pulse width analysis of etoposide‐induced nuclear enlargement in HCT116 cells . Biotechnol. Lett. 32 , 1045 – 1052 .
Kimura , Y. and K. Baba ( 2003 ) Antitumor and antimetasttic activities of Angelica keiskei roots, part 1: isolation of an active substance, xanthoangelol . Int. J. Cancer 106 , 429 – 437 .
Kimura , Y. , M. Taniguchi and K. Baba ( 2004 ) Antitumor and antimetastatic activities of 4‐hydroxyderricin isolated from Angelica keiskei roots . Planta Med. 70 , 211 – 219 .
Kimura , Y. , M. Sumiyoshi , M. Taniguchi and K. Baba ( 2008 ) Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum . J. Nat. Med. 62 , 308 – 313 .
Kimura , Y. , M. Sumiyoshi and K. Baba ( 2008 ) Anti‐tumor actions of major component 3′‐ o ‐acetylhamaudol of Angelica japonica roots through dual actions, anti‐angiogenesis and intestinal intraepithelial lymphocyte activation . Cancer Lett. 265 , 84 – 97 .
Hata , K. , M. Kozawa and K. Baba ( 1972 ) Coumarins from chinese crude drug “She Juangzi”, the fruits of Cnidium sp. and from Cnidium japonicum Miq . Yakugaku Zasshi 92 , 1289 – 1294 . (In Japanese).
Kozawa , M. , K. Baba , K. Okuda , T. Fukumoto and K. Hata ( 1981 ) Studies on chemical components of “Bai Zhi” (Supplement 1). On coumarins from “Japanese Bai Zhi” . Shouyakugaku Zasshi 35 , 90 – 95 . (In Japanese).
Baba , K. , Y. Matsuyama , M. Fukumoto and M. Kozawa ( 1983 ) Chemical studies of Angelica ursine Maxim . Yakugaku Zasshi 103 , 1091 – 1095 . (In Japanese).
Sumoyoshi , M. , M. Sakanaka , M. Taniguchi , K. Baba and Y. Kimura ( 2013 ) Antitumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation . J. Nat. Med. doi: 10.1007/S11418‐013‐0774‐z. [Epub ahead of print].
Nyberg , K. A. , R. J. Michelson , C. W. Putnam and T. A. Weinert ( 2002 ) Toward maintain the genome: DNA damage and replication checkpoints . Ann. Rev. Genet. 36 , 617 – 656 .
Sancar , A. , L. A. Lindsey‐Boltz , K. Unsal‐Kacmaz and S. Linn ( 2004 ) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints . Ann. Rev. Biochem. 73 , 39 – 85 .
Bartek , J. and J. Lukas ( 2003 ) Chk1 and Chk2 kinases in checkpoint control and cancer . Cancer Cell 3 , 421 – 429 .
Furnari , B. , N. Rhind and P. Russell ( 1997 ) Cdc25 mitoic inducer targeted by Chk1 DNA damage checkpoint kinase . Science 277 , 1495 – 1497 .
Sanchez , Y. , C. Wong , R. S. Thoma , R. Richman , Z. Wu , H. Piwnica‐Worms and S. J. Elledge ( 1997 ) Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to cdk regulation through cdc25 . Science 277 , 1497 – 1501 .
Peng , C.‐Y. , P. R. Graves , R. S. Thoma , Z. Wu , A. S. Shaw and H. Piwnica‐Worms ( 1997 ) Mitotic and G 2 checkpoint control: regulation of 14‐3‐3 protein binding by phosphorylation of cdc 25C on serine‐216 . Science 277 , 1501 – 1505 .
Attherton‐Fessler , S. , F. Liu , B. Gabrielli , M. S. Lee C. Y. Peng and H. Piwnica‐Worms ( 1994 ) Cell cycle regulation of the p34cdc2 inhibitory kinases . Mol. Biol. Cell 5 , 989 – 1001 .
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