$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

A Review of Experimental Research on Herbal Compounds in Amyotrophic Lateral Sclerosis

Phytotherapy research : PTR, v.28 no.1, 2014년, pp.9 - 21  

Zhang, Xue (Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Hong, Yan‐Long (Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Xu, De‐Sheng (Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Feng, Yi (Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Zhao, Li‐Jie (Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Ruan, Ke‐Feng (Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Yang, Xiu‐Juan (Engineerin)

Abstract AI-Helper 아이콘AI-Helper

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease worldwide, leading to progressive muscle atrophy and paralysis. The limited success of conventional treatment for ALS has prompted investigations into complementary and alternative therapies. Herbal remedies provide ...

주제어

참고문헌 (109)

  1. Bai JR , Liu YJ , Song Y , et al . 2008 . The mechanism of interfere effects of madecassoside (MC) on neurodegeneration in mice . Chin J Gerontol 28 : 2297 – 2300 . 

  2. Bensimon G , Lacomblez L , Meininger V . 1994 . A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group . N Engl J Med 330 : 585 – 591 . 

  3. Bergeron C . 1995 . Oxidative stress: its role in the pathogenesis of amyotrophic lateral sclerosis . J Neurol Sci 129 : 81 – 84 . 

  4. Bi XL , Yang JY , Dong YX , et al . 2005 . Resveratrol inhibits nitric oxide and TNF‐alpha production by lipopolysaccharide‐activated microgria . Int Immunopharmacol 5 : 185 – 193 . 

  5. Boillée S , Yamanaka K , Lobsiger CS , et al . 2006 . Onset and progression in inherited ALS determined by motor neurons and microglia . Science 312 : 1389 – 1392 . 

  6. Borrás‐Blasco J , Plaza‐Macías I , Navarro‐Ruiz A , et al . 1998 . Riluzole as a treatment for amyotrophic lateral sclerosis . Rev Neurol 27 : 1021 – 1027 . 

  7. Burns J , Yokota T , Ashihara H , et al . 2002 . Plant foods and herbal sources of resveratrol . J Agric Food Chem 50 : 3337 – 3340 . 

  8. Calò LA , Fusaro M , Davis PA . 2010 . HO‐1 attenuates hypertension‐induced inflammation/oxidative stress: support from Bartter's/Gitelman's patients . Am J Hypertens 23 : 936 . 

  9. Cao Y , Liu JW , Yu YJ , et al . 2007 . Synergistic protective effect of picroside II and NGF on PC12 cells against oxidative stress induced by H2O2 . Pharmacol Rep 59 : 573 – 579 . 

  10. Chang MX , Xu LY , Tao JS , et al . 1993 . Studies on metabolism and pharmacokinetics of ferulic acid in mice . China Journal of Chinese Materia Medica 18 : 300 – 302 . 

  11. Chen WD , Lu XL , Li L , et al . 2000 . Effect of gastrodin on release of glutamate from cultured nerve cells induced by potassium chloride . Chinese Journal of Natural Medicine 2 : 8 – 10 . 

  12. Chen YZ , Gu YJ , Wu XM . 2004 . Protective effect of Acanthopanax senticousus saponins on glutamate‐induced cortical neuron damage . Journal of Brain and Nervous Diseases 12 : 84 – 87 . 

  13. Chen JL , Wang DH , Zhou SL . 2005 . Clinical observation on treatment of motor neuron diseases by jiweiling injection . Chinese Journal of Integrated Traditional and Western Medicine 25 : 66 – 67 . 

  14. Chen DM , Xiao L , Cai X , et al . 2006 . Involvement of multitargets in paeoniflorin induced preconditioning . J Pharmacol Exp Ther 319 : 165 – 180 . 

  15. Chen YZ , Fang YQ , Liang Y , et al . 2007 . Protective effects of β‐asarone on PC12 cells damage induced by glutamate . Chinese Journal of Information on Traditional Chinese Medicine 14 : 22 – 23 . 

  16. Chen JL , Hu JY , Wang DH . 2008 . Clinical efficacy observation on treatment of chronic respiratory failure of amyotrophic lateral sclerosis with Qilong Yiqi powder . China Journal of Chinese Materia Medica 33 : 2142 – 2143 . 

  17. Cho J , Kim YH , Kong JY , et al . 2002 . Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus . Life Sci 71 : 591 – 599 . 

  18. Contestabile A . 2001 . Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives . Curr Top Med Chem 1 : 553 – 568 . 

  19. Deng Y , Wang N , Zhu Q , et al . 2008 . Neuroprotective effects of ferulic acid against glutamate‐induced neurotoxicity in PC12 cells . Pharmacology and Clinics of Chinese Materia Medica 24 : 32 – 34 . 

  20. Diao HX , Song SL , Liang H , et al . 2009 . Protective effect of polysaccharides from sea cucumber on Glu‐induced neurotoxicity in PC12 cells . J Chinese Medicinal Materials 32 : 398 – 400 . 

  21. Drachman DB , Kuncl RW . 1989 . Amyotrophic lateral sclerosis: an unconventional autoimmune disease? Ann Neurol 26 : 269 – 274 . 

  22. Du ZY , Li XY . 1998 . Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro . Acta Pharmacol Sin 19 : 467 – 470 . 

  23. Du YF , Sun ZL , Li Y , et al . 2004 . Effects of ligustrazine on L‐type calcium current in SH‐SY5Y human neuroblastoma . Chinese Journal of Neuroimmunology and Neurology 11 : 43 – 45 . 

  24. Gordon RK , Nigam SV , Weitz JA , et al . 2001 . The NMDA receptor ion channel: a site for binding of Huperzine A . J Appl Toxicol 21 : S47 – S51 . 

  25. Grosskreutz J , Van Den Bosch L , Keller BU . 2010 . Calcium dysregulation in amyotrophic lateral sclerosis . Cell Calcium 47 : 165 – 174 . 

  26. Guo Q , Li YK , Wang ZG , et al . 2009 . Advances in pharmacology of paeonol . Information on Traditional Chinese Medicine 26 : 20 – 22 . 

  27. Guo YS , Zhang KX , Wang Q , et al . 2011 . Neuroprotective effects of diallyl trisulfide in SOD1‐G93A transgenic mouse model of amyotrophic lateral sclerosis . Brain Res 1374 : 110 – 115 . 

  28. Gutierrez‐Merino C , Lopez‐Sanchez C , Lagoa R , et al . 2011 . Neuroprotective actions of flavonoids . Curr Med Chem 18 : 1195 – 1212 . 

  29. Ha SK , Moon E , Kim SY . 2010 . Chrysin suppresses LPS‐stimulated proinflammatory responses by blocking NF‐κB and JNK activations in microglia cells . Neurosci Lett 485 : 143 – 147 . 

  30. Han YM , Xie HY . 1996 . Effect of traditional Chinese medicine on excitatory neurotransmitter . Acta Academiae Medicinae Jiangxi 36 : 13 – 15 . 

  31. Hemendinger RA , Armstrong EJ , Persinski R , et al . 2008 . Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death . Neurotox Res 13 : 49 – 61 . 

  32. Hockenbery DM , Oltvai ZN , Yin XM , et al . 1993 . Bcl‐2 function in an antioxidant pathway to prevent apoptosis . Cell 75 : 241 – 251 . 

  33. Ito K , Iida T , Ichino K , et al . 1982 . Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb . Chem Pharm Bull(Tokyo) 30 : 3347 – 3353 . 

  34. Jiang B , Liu JH , Bao YM , et al . 2004 . Catalpol inhibits apoptosis in hydrogen peroxide‐induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade . Toxicon 43 : 53 – 59 . 

  35. Jin Y , Yan EZ , Fan Y , et al . 2007 . Neuroprotection by sodium ferulate against glutamate‐induced apoptosis is mediated by ERK and PI3 kinase pathways . Acta Pharmacol Sin 28 : 1881 – 1890 . 

  36. Jung HW , Chung YS , Kim YS , et al . 2007 . Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF‐kappaB in LPS‐stimulated BV‐2 microglial cells . Exp Mol Med 39 : 715 – 721 . 

  37. Kambara T , Zhou YY , Oda M , et al . 2000 . Anti‐oxidative activities of Ampelopsis grossedentata . Abstract of 120th Annual Meeting of Pharmaceutical Society of Japan ( Gifu ) 2 : 51 . 

  38. Kanekura K , Hashimoto Y , Kita Y , et al . 2005 . A Rac1/phosphatidylinositol 3‐kinase/Akt3 anti‐apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn‐superoxide dismutase (SOD1) mutant‐induced motoneuronal cell death . J Biol Chem 280 : 4532 – 4543 . 

  39. Kiaei M , Kipiani K , Petri S , et al . 2005 . Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis . Neurodegenerative Dis 2 : 24 – 54 . 

  40. Ko HM , Koppula S , Kim BW , et al . 2010 . Inflexin attenuates proinflammatory responses and nuclear factor‐kappaB activation in LPS treated microglia . Eur J Pharmacol 633 : 98 – 106 . 

  41. Kobayashi Y , Liu YJ , Tobinaga S , et al . 2007 . Effects of madecassoside on amyotrophic lateral sclerosis model mice . J Pharmacol Sci 103 : 136P – 136P . 

  42. Koh SH , Lee SM , Kim HY , et al . 2006 . The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice . Neurosci Lett 395 : 103 – 107 . 

  43. Kou XJ , Shen KY , An YH , et al . 2012 . Ampelopsin inhibits H2O2‐induced apoptosis by ERK and Akt signaling pathways and up‐regulation of heme oxygenase‐1 . Phytother Res . 26 : 988 – 994 . 

  44. Kuroda M , Mimaki Y , Sashida Y , et al . 2000 . Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells . Planta Med 66 : 575 – 577 . 

  45. Lee H , Kim YO , Kim H , et al . 2003 . Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia . FASEB J 17 : 1943 – 1944 . 

  46. von Lewinski F , Keller BU . 2005 . Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS . Trends Neurosci 28 : 494 – 500 . 

  47. Li P , Matsunaga K , Ohizumi Y . 2000 . Nerve growth factor‐potentiating compounds from Picrorhizae Rhizoma . Biol Pharm Bull 23 : 890 – 892 . 

  48. Li YM , Chen FP , Liu GQ . 2003 . Studies on inhibitive effect of gastrodin on PC12 cell damage induced by glutamate and H2O2 . Journal of China Pharmaceutical University 34 : 456 – 460 . 

  49. Li T , Liu JW , Zhang XD , et al . 2007 . The neuroprotective effect of picroside II from Hu‐Huang‐Lian against oxidative stress . Am J Chin Med 35 : 681 – 691 . 

  50. Liang AQ . 2005 . Study on pharmacology and mechanism of Ligustrazine . Lishizhen Medicine and Materia Medica Research 16 : 532 – 533 . 

  51. Liu JS , Yu CM , Zhou YZ , et al . 1986 . Study on the chemistry of huperzine A and B . Acta Chimica Sinica 44 : 1035 – 1040 . 

  52. Liu YJ , Kobayashi Y , Li SH , et al . 2006 . Therapeutic potential of madecassoside in transgenic mice of amyotrophic lateral sclerosis . Chinese Traditional and Herbal Drugs 37 : 718 – 720 . 

  53. Liu R , Liu JF , Xu KP , et al . 2011 . Chemical constituents in Selaginella tamariscina . Central South Pharmacy 9 : 564 – 566 . 

  54. Luo , L , Sun Y . 2011 . Neuroprotective effect of ferulic acid in vitro . Journal of Chinese Medicinal Materials 34 : 1750 – 1753 . 

  55. Luo PZ , Zhen HS , Long SJ . 1995a . Study on the effect of 15 kinds of heat‐clearing medicine on oxygen free radical scavenging . Guangxi Journal of Traditional Chinese Medicine 18 : 51 – 52 . 

  56. Luo PZ , Zhen HS , Long SJ . 1995b . Study on the effect of 20 kinds of Qi medicine on oxygen free radical scavenging . Hubei Journal of Traditional Chinese Medicine 17 : 47 – 49 . 

  57. Ma Z , Yang Z . 1999 . Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2‐. and .OH . Journal of Chinese Medicinal Materials 22 : 303 – 306 . 

  58. Ma W , Ma WD , Miao ZH , et al . 2011 . Protective effect of paeoniflorin on the Aβ(1‐40)‐induced neurotoxicity in cultured PC12 Cells . Journal of Ningxia Medical College 33 : 132 – 134 . 

  59. Mandel S , Weinreb O , Amit T , et al . 2004 . Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases . J Neurochem 88 : 1555 – 1569 . 

  60. Mao QQ , Zhong XM , Feng CR , et al . 2010 . Protective effects of paeoniflorin against glutamate induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca(2+) antagonism . Cell Mol Neurobiol 30 : 1059 – 1066 . 

  61. Mao QQ , Zhong XM , Li ZY , et al . 2011 . Paeoniflorin protects against NMDA‐induced neurotoxicity in PC12 cells via Ca2+ antagonism . Phytother Res 25 : 681 – 685 . 

  62. McGeer PL , McGeer EG . 2002 . Inflammatory processes in amyotrophic lateral sclerosis . Muscle Nerve 26 : 459 – 470 . 

  63. Meng XL , Yang JY , Chen GL , et al . 2008 . Effects of resveratrol and its derivatives on lipopolysaccharide‐induced microglial activation and their structure‐activity relationships . Chem Biol Interact 174 : 51 – 59 . 

  64. Miao B , Gao JX , Liu XX , et al . 2004 . The effects of ginkgolide B on the activity of neurons . Shandong Medical Journal 44 : 16 – 18 . 

  65. Miller RG , Mitchell JD , Lyon M , et al . 2003 . Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) . Amyotroph Lateral Scler Other Motor Neuron Disord 4 : 191 – 206 . 

  66. Morita T . 2010 . Celastrol: a new therapeutic potential of traditional Chinese medicine . Am J Hypertens 23 : 821 . 

  67. Mulder DB , Kurland LT , Oford KP . 1986 . Familial adult motor neuron disease: amyotrophic lateral sclerosis . Neurology 36 : 511 – 517 . 

  68. Murakami T , Miyakoshi M , Araho D , et al . 2004 . Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin . Biofactors 21 : 175 – 178 . 

  69. Niebroj‐Dobosz I , Janik P . 1999 . Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS) . Acta Neurol Scand 100 : 6 – 11 . 

  70. Ock J , Han HS , Hong SH , et al . 2010 . Obovatol attenuates microglia‐mediated neuroinflammation by modulating redox regulation . Br J Pharmacol 159 : 1646 – 1662 . 

  71. Piao HZ , Cui H , Piao RL , et al . 2008 . Effects of wogonin on LPS‐induced production of proinflammatory cytokines . Journal of Xi'an Jiaotong University: Medical Sciences 29 : 230 – 233 . 

  72. Rong J , Cheung CY , Lau AS , et al . 2008 . Induction of heme oxygenase‐1 by traditional Chinese medicine formulation ISF‐1 and its ingredients as a cytoprotective mechanism against oxidative stress . Int J Mol Med 21 : 405 – 411 . 

  73. Rothstein JD , Martin LJ , Kuncl RW . 1992 . Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis . N Engl J Med 326 : 1464 – 1468 . 

  74. Seagar MJ , Martin‐Moutot N , Leveque C , et al . 1995 . Anti‐calcium channel autoantibodies in amyotrophic lateral sclerosis. A review of the evidence . Adv Neurol 68 : 67 – 72 . 

  75. Shaw PJ , Ince P . 1997 . Glutamate, excitotoxicity and amyotrophic lateral sclerosis . J Neurol 244 : S3 – S14 . 

  76. Sikora E , Scapagnini G , Barbagallo M . 2010 . Curcumin, inflammation, ageing and age‐related diseases . Immun Ageing 7 : 1 . 

  77. Simpson EP , Yen AA , Appel SH . 2003 . Oxidative stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis . Currt Opin Rheumatol 15 : 730 – 736 . 

  78. Song Y , Liu JP , Shi FG , et al . 2011 . Inhibitory effect of isorhynchophylline on lipopolysaccharide stimulated release of inflammatory mediators in primary rat astrocytes . Pharmacertical and Clinical Research 19 : 311 – 314 . 

  79. Sun MM , Bu H , Li B , et al . 2009a . Neuroprotective potential of phase II enzyme inducer diallyl trisulfide . Neurol Res 31 : 23 – 27 . 

  80. Sun R , Zhang ZP , Huang W , et al . 2009b . Protective effects and mechanism of muskone on pheochromocytoma cell injure induced by glutamate . China Journal of Chinese Materia Medica 34 : 1701 – 1704 . 

  81. Swash M , Schwartz MS . 1992 . What do we really know about amyotrophic lateral sclerosis? J Neurol Sci 113 : 4 – 16 . 

  82. Tseng YT , Hsu YY , Shih YT , et al . 2012 . Paeonol attenuates microglia‐mediated inflammation and oxidative stress‐induced neurotoxicity in rat primary microglia and cortical neurons . Shock (Augusta, Ga) 37 : 312 – 318 . 

  83. Van Damme P , Dewil M , Robberecht W , et al . 2005 . Excitotoxicity and amyotrophic lateral sclerosis . Neurodegener Dis 2 : 147 – 159 . 

  84. Ved HS , Koenig ML , Dave JR , et al . 1997 . Huperzine A, a potential therapeutic agent for dementia ,reduces neuronal cell death caused by glutamate . Neuroreport 8 : 963 – 967 . 

  85. Wang JH , Kang B , Hu YE , et al . 2008a . Catalpol attenuates PC12 cells injury induced by l ‐glutamate . Chinese Pharmacological Bulletin 24 : 1258 – 1259 . 

  86. Wang W , Huang W , Li L , et al . 2008b . Morroniside prevents peroxide‐induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells . Cell Mol Neurobiol 28 : 293 – 305 . 

  87. Wang W , Sun F , An Y , et al . 2009 . Morroniside protects human neuroblastoma SH‐SY5Y cells against hydrogen peroxide‐induced cytotoxicity . Eur J Pharmacol 613 : 19 – 23 . 

  88. Wang CJ , Hu CP , Xu KP , et al . 2010a . Protective effect of selaginellin on glutamate‐induced cytotoxicity and apoptosis in differentiated PC12 cells . Naunyn Schmiedbergs Arch Pharmacol 381 : 73 – 81 . 

  89. Wang W , Xu J , Li L , et al . 2010b . Neuroprotective effect of morroniside on focal cerebral ischemia in rats . Brain Res Bull 83 : 196 – 201 

  90. Wang SB , Qiu JF , Bai QH , et al . 2011a . A study on protection of astragaioside IV about oxidative stress on PC12 cells induced by H2O2 . Chinese Pharmacological Bulletin 27 : 1603 – 1609 . 

  91. Wang X , Zhu G , Yang S , et al . 2011b . Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via downregulation of ERK activation and inhibition of apoptosis . Planta Med 77 : 1695 – 1701 . 

  92. Weinges K , Kloss P , Henkels WD . 1972 . Natural products from medicinal plants. XVII. Picroside‐II, a new 6‐vanilloyl‐catapol from Picrorhiza kurooa Royle and Benth . Justus Liebigs Ann Chem 759 : 173 – 182 . 

  93. Weydt P , Möller T . 2005 . Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis . Neuroreport 16 : 527 – 531 . 

  94. Weydt P , Weiss MD , Möller T , et al . 2002 . Neuro‐inflammation as a therapeutic target in amyotrophic lateral sclerosis . Curr Opin Investig Drugs 3 : 1720 – 1724 . 

  95. Wokke J . 1996 . Riluzole . Lancet 348 : 795 – 799 . 

  96. Wu C , Chen LL . 2005 . Study on scavenging activity of free radicals by semen cuscutae flavonoids . Natural Product Research and Development 17 : 553 – 556 . 

  97. Wu YG , Zhi HP , Gao JP . 2004 . Clinical trial of Fuyuan Shengji granule (granule for recovery and regeneration of the tissue) in the treatment of amyotrophic lateral sclerosis . Neurol Neurorehabil 1 : 201 – 203 . 

  98. Xu Z , Chen S , Li X , et al . 2006 . Neuroprotective effects of (‐)‐epigallocatechin‐3‐gallate in a transgenic mouse model of amyotrophic lateral sclerosis . Neurochem Res 31 : 1263 – 1269 . 

  99. Yang J , He LN , He SB . 2001 . Protective effects of paeoniflorin on calcium overloading induced by NMDA in cultured PC12 cells . Chinese Journal of New Drugs 10 : 426 – 428 . 

  100. Yang KY , Gu JL , Yin DM , et al . 2007 . Effect of curcumin on iNOS expression in LPS‐activated microglia cells and anti‐oxidation . Chinese Journal of Biochemistry and Molecular Biology 23 : 938 – 945 . 

  101. Yin WK , Shi XD , Zhang X , et al . 2010 . Curcumins upregulate expression of HO‐1 via inducing Nrf‐2 in SH‐SY5Y cells . Chinese Pharmacological Bulletin 26 : 1054 – 1059 . 

  102. You JH , Tan TZ , Kuang AR , et al . 1994 . Biodistribution and metabolism of 3H‐Gastrodigenin and 3H‐Gastrodin in mice . Journal of West China University of Medical Sciences 25 : 325 – 328 . 

  103. Yu D , Duan Y , Bao Y , et al . 2005 . Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by l ‐glutamate . J Ethnopharmacology 98 : 89 – 94 . 

  104. Yu DH , Bao YM , An LJ , et al . 2009 . Protection of PC12 cells against superoxide‐induced damage by isoflavonoids from Astragalus mongholicus . Biomed Environ Sci 22 : 50 – 54 . 

  105. Yuan D , Ma B , Yang JY , et al . 2009 . Anti‐inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism . Int Immunopharmacol 9 : 1549 – 1554 . 

  106. Zhang FY , Zheng WH , Pi RB , et al . 2009 . Cryptotanshinone protects primary rat cortical neurons from glutamate‐induced neurotoxicity via the activation of the phosphatidylinositol 3‐kinase/Akt signaling pathway . Exp Brain Res 139 : 109 – 118 . 

  107. Zhao XR . 1993 . Research progress on antioxidation agents in traditional Chinese herb . Qianwei Medical Information 9 : 125 – 126 . 

  108. Zhen GH , Jiang B , Bao YM , et al . 2006 . The protect effect of flavonoids from Cuscuta chinensis in PC12 ceils from damage induced by H2O2 . Journal of Chinese Medicinal Materials 29 : 1051 – 1055 . 

  109. Zheng M , Fan DS . 2011 . Different distribution of NMDA receptor subunits in cortex contributes to selective vulnerability of motor neurons in amyotrophic lateral sclerosis . Beijing Da Xue Xue Bao 43 : 228 – 233 . 

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로