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Neurobiology of aging, v.35 no.5, 2014년, pp.941 - 957
Tan, C.C. , Yu, J.T. , Tan, M.S. , Jiang, T. , Zhu, X.C. , Tan, L.
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Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and molecular pathogenetic mechanism involving aberrant misfolded protein or peptide aggregation and deposition. Autophagy represents a major ...
Neurobiol Dis. Alvarez-Erviti 42 360 2011 10.1016/j.nbd.2011.01.029 Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Cell Death Differ. Arena 20 920 2013 10.1038/cdd.2013.19 PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
J. Cell Biol. Axe 182 685 2008 10.1083/jcb.200803137 Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
PloS One Balgi 4 e7124 2009 10.1371/journal.pone.0007124 Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
Cancer Res. Ben Sahra 71 4366 2011 10.1158/0008-5472.CAN-10-1769 Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
Mol. Cell Bennett 17 351 2005 10.1016/j.molcel.2004.12.021 Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation
J. Alzheimer's Dis. Bharadwaj 32 949 2012 10.3233/JAD-2012-120178 Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-aβ 42 levels in yeast
Cell Metab. Bjedov 11 35 2010 10.1016/j.cmet.2009.11.010 Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
J. Neurosci. Boland 28 6926 2008 10.1523/JNEUROSCI.0800-08.2008 Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
Cell Metab. Canto 11 213 2010 10.1016/j.cmet.2010.02.006 Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
Cell Cardenas 142 270 2010 10.1016/j.cell.2010.06.007 Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria
PloS One Cartier 7 e34713 2012 10.1371/journal.pone.0034713 Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy
Acta Pharmacol. Sin. Chen 33 385 2012 10.1038/aps.2011.162 Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes
J. Cell. Mol. Med. Cheung 15 244 2011 10.1111/j.1582-4934.2009.00990.x Temporal relationship of autophagy and apoptosis in neurons challenged by low molecular weight beta-amyloid peptide
Hum. Mol. Genet. Crippa 19 3440 2010 10.1093/hmg/ddq257 The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
Science Cuervo 305 1292 2004 10.1126/science.1101738 Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
Mol. Cell. Biochem. Cuervo 263 55 2004 10.1023/B:MCBI.0000041848.57020.57 Autophagy: many paths to the same end
Nat. Commun. Dall'Armi 1 142 2010 10.1038/ncomms1144 The phospholipase D1 pathway modulates macroautophagy
PloS One Davidson 4 e6951 2009 10.1371/journal.pone.0006951 Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression
Hum. Mol. Genet. Davies 15 23 2006 10.1093/hmg/ddi422 Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy
Neuron de Calignon 73 685 2012 10.1016/j.neuron.2011.11.033 Propagation of tau pathology in a model of early Alzheimer's disease
Proc. Natl. Acad. Sci. U.S.A Decressac 110 E1817 2013 10.1073/pnas.1305623110 TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity
Neurochem. Int. Deng 63 1 2013 10.1016/j.neuint.2013.04.005 Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
Neurobiol. Dis. Di Zanni 45 508 2012 10.1016/j.nbd.2011.09.007 In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins
FASEB J. Domanskyi 25 2898 2011 10.1096/fj.11-181958 Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
Science Egan 331 456 2011 10.1126/science.1196371 Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
Nat. Cell. Biol. Eisenberg 11 1305 2009 10.1038/ncb1975 Induction of autophagy by spermidine promotes longevity
Arch. Neurol. Fecto 68 1440 2011 10.1001/archneurol.2011.250 SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis
PLoS Biol. Feldman 7 e38 2009 10.1371/journal.pbio.1000038 Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
Eur. J. Neurosci. Feng 32 10 2010 10.1111/j.1460-9568.2010.07266.x Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability
Neurobiol. Aging Filomeni 33 767 2012 10.1016/j.neurobiolaging.2010.05.021 Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease
Autophagy Floto 3 620 2007 10.4161/auto.4898 Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages
Radiat. Oncol. Fokas 7 48 2012 10.1186/1748-717X-7-48 NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
Proc. Natl. Acad. Sci. U.S.A Fornai 105 2052 2008 10.1073/pnas.0708022105 Lithium delays progression of amyotrophic lateral sclerosis
EMBO J. Fraldi 29 3607 2010 10.1038/emboj.2010.237 Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders
J. Biol. Chem. Ganley 284 12297 2009 10.1074/jbc.M900573200 ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
Neurobiol. Aging Garcia 32 2045 2011 10.1016/j.neurobiolaging.2009.12.013 Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice
PloS One Gill 4 e6489 2009 10.1371/journal.pone.0006489 No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS
Brain Res. Guo 1353 234 2010 10.1016/j.brainres.2010.07.025 Ultrastructural diversity of inclusions and aggregations in the lumbar spinal cord of SOD1-G93A transgenic mice
Cell Hailey 141 656 2010 10.1016/j.cell.2010.04.009 Mitochondria supply membranes for autophagosome biogenesis during starvation
Eur. J. Neurosci. Hamano 27 1119 2008 10.1111/j.1460-9568.2008.06084.x Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
Nature Hamasaki 495 389 2013 10.1038/nature11910 Autophagosomes form at ER-mitochondria contact sites
J. Biol. Chem. Hanada 282 37298 2007 10.1074/jbc.C700195200 The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
Genes Dev. Hetz 23 2294 2009 10.1101/gad.1830709 XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Sin He 34 605 2013 Autophagy in ageing and ageing-associated diseases. Acta Pharmacol
Mol. Biol. Cell Hosokawa 20 1981 2009 10.1091/mbc.E08-12-1248 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
Biochim. Biophys. Acta Hyttinen 1833 503 2013 10.1016/j.bbamcr.2012.11.018 Maturation of autophagosomes and endosomes: a key role for Rab7
PloS One Ikenaka 8 e54511 2013 10.1371/journal.pone.0054511 dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration
Biochem. Biophys. Res. Commun. Imai 351 595 2006 10.1016/j.bbrc.2006.10.056 LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells
PloS One Jaeger 5 e11102 2010 10.1371/journal.pone.0011102 Regulation of amyloid precursor protein processing by the Beclin 1 complex
J. Cell Sci. Jager 117 4837 2004 10.1242/jcs.01370 Role for Rab7 in maturation of late autophagic vacuoles
Cell Jeong 137 60 2009 10.1016/j.cell.2009.03.018 Acetylation targets mutant huntingtin to autophagosomes for degradation
Hum. Mol. Genet. Jia 21 5280 2012 10.1093/hmg/dds379 Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems
Curr. Alzheimer Res. Jiang 10 852 2013 10.2174/15672050113109990155 Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors
J. Cell Biol. Juhasz 181 655 2008 10.1083/jcb.200712051 The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
Science Kaeberlein 310 1193 2005 10.1126/science.1115535 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
Mol. Cell. Biol. Kamada 30 1049 2010 10.1128/MCB.01344-09 Tor directly controls the Atg1 kinase complex to regulate autophagy
Cell Death Differ Kang 18 571 2011 10.1038/cdd.2010.191 The Beclin 1 network regulates autophagy and apoptosis
Neurochem. Int. Kasparova 48 93 2006 10.1016/j.neuint.2005.09.002 Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease
Int. J. Geriatr. Psychiatry Kennelly 27 415 2012 10.1002/gps.2735 Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients-an open-label trial
Nat. Cell. Biol. Kim 13 132 2011 10.1038/ncb2152 AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Neurobiol. Dis. Koga 43 29 2011 10.1016/j.nbd.2010.07.006 Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration
Cell Lee 141 1146 2010 10.1016/j.cell.2010.05.008 Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
J. Neurosci. Lee 31 7817 2011 10.1523/JNEUROSCI.6412-10.2011 Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
Dev. Cell Levine 6 463 2004 10.1016/S1534-5807(04)00099-1 Development by self-digestion: molecular mechanisms and biological functions of autophagy
Cell Levine 132 27 2008 10.1016/j.cell.2007.12.018 Autophagy in the pathogenesis of disease
Acta Pharmacol. Sin. Li 34 644 2013 10.1038/aps.2012.190 Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis
Curr. Alzheimer Res. Li 10 433 2013 10.2174/1567205011310040008 Autophagy enhancer carbamazepine alleviates memory deficits and cerebral amyloid-beta pathology in a mouse model of Alzheimer's disease
Autophagy Li 4 290 2008 10.4161/auto.5524 Altered macroautophagy in the spinal cord of SOD1 mutant mice
Neurodegener. Dis. Li 7 265 2010 10.1159/000276710 Autophagy dysfunction in Alzheimer's disease
Biochem. Pharmacol. Li 81 1152 2011 10.1016/j.bcp.2011.02.015 EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages
Nat. Commun. Li 3 662 2012 10.1038/ncomms1648 Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
Int. J. Neurosci. Li 123 73 2013 10.3109/00207454.2012.729234 Therapeutic effects of valproate combined with lithium carbonate on MPTP-induced parkinsonism in mice: possible mediation through enhanced autophagy
Nat. Cell Biol. Liang 9 218 2007 10.1038/ncb1537 The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
Proc. Natl. Acad. Sci. U.S.A Lipinski 107 14164 2010 10.1073/pnas.1009485107 Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
Neurobiol. Aging Liu 34 1564 2013 10.1016/j.neurobiolaging.2012.11.020 Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
J. Biol. Chem. Liu 287 9742 2012 10.1074/jbc.M111.304485 Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics
Neuron Lucin 79 873 2013 10.1016/j.neuron.2013.06.046 Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
Science Luk 338 949 2012 10.1126/science.1227157 Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
Exp. Gerontol. Ma 46 533 2011 10.1016/j.exger.2011.02.006 Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice
Neurobiol. Dis. Malkus 46 732 2012 10.1016/j.nbd.2012.03.017 Regional deficiencies in chaperone-mediated autophagy underlie alpha-synuclein aggregation and neurodegeneration
Biochim. Biophys. Acta Marambio 1802 509 2010 10.1016/j.bbadis.2010.02.002 Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Nat. Neurosci. Martinez-Vicente 13 567 2010 10.1038/nn.2528 Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
EMBO Rep. Matsui 14 450 2013 10.1038/embor.2013.32 Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4
Autophagy McCoy 7 531 2011 10.4161/auto.7.5.14684 DJ-1 regulation of mitochondrial function and autophagy through oxidative stress
Dev. Cell Medina 21 421 2011 10.1016/j.devcel.2011.07.016 Transcriptional activation of lysosomal exocytosis promotes cellular clearance
Proc. Natl. Acad. Sci. U.S.A Meissner 107 13046 2010 10.1073/pnas.1002396107 Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis
J. Neurol. Sci. Meng 332 4 2013 10.1016/j.jns.2013.05.029 Role of the mTOR signaling pathway in epilepsy
Brain Menzies 133 93 2010 10.1093/brain/awp292 Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3
Cell Death Dis. Metcalfe 3 e326 2012 10.1038/cddis.2012.70 Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP
Curr. Mol. Med. Mestre 13 241 2013 10.2174/156652413804810790 Autophagy and toxins: a matter of life or death
Cell Death Differ. Michiorri 17 962 2010 10.1038/cdd.2009.200 The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
Aging Cell Minina 12 327 2013 10.1111/acel.12048 Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis
Brain Res. Morimoto 1167 112 2007 10.1016/j.brainres.2007.06.045 Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
Cell Death Dis. Morselli 1 e10 2010 10.1038/cddis.2009.8 Caloric restriction and resveratrol promote longevity through the sirtuin-1-dependent induction of autophagy
Autophagy Morselli 6 186 2010 10.4161/auto.6.1.10817 The life span-prolonging effect of sirtuin-1 is mediated by autophagy
J. Cell Biol. Morselli 192 615 2011 10.1083/jcb.201008167 Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Neuron Moughamian 74 331 2012 10.1016/j.neuron.2012.02.025 Dynactin is required for transport initiation from the distal axon
Cell Nakatogawa 130 165 2007 10.1016/j.cell.2007.05.021 Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion
J. Cell Biol. Narendra 183 795 2008 10.1083/jcb.200809125 Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Trends Neurosci. Nixon 29 528 2006 10.1016/j.tins.2006.07.003 Autophagy in neurodegenerative disease: friend, foe or turncoat?
Nat. Med. Nixon 19 983 2013 10.1038/nm.3232 The role of autophagy in neurodegenerative disease
J. Neuropathol. Exp. Neurol. Nixon 64 113 2005 10.1093/jnen/64.2.113 Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
Neurobiol. Dis. Nixon 43 38 2011 10.1016/j.nbd.2011.01.021 Autophagy failure in Alzheimer's disease-locating the primary defect
Br. J. Psychiatry Nunes 190 359 2007 10.1192/bjp.bp.106.029868 Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder
Nat. Neurosci. Orenstein 16 394 2013 10.1038/nn.3350 Interplay of LRRK2 with chaperone-mediated autophagy
Redox Rep. Persson 6 327 2001 10.1179/135100001101536472 Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis
J. Biol. Chem. Petiot 275 992 2000 10.1074/jbc.275.2.992 Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
J. Clin. Invest. Pickford 118 2190 2008 The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
Amyotroph. Lateral Scler. Pizzasegola 10 221 2009 10.1080/17482960902803440 Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
Nat. Genet. Puls 33 455 2003 10.1038/ng1123 Mutant dynactin in motor neuron disease
PloS One Rakovic 6 e16746 2011 10.1371/journal.pone.0016746 Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts
Nat. Cell Biol. Ravikumar 12 747 2010 10.1038/ncb2078 Plasma membrane contributes to the formation of pre-autophagosomal structures
Nat. Genet. Ravikumar 36 585 2004 10.1038/ng1362 Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Hum. Mol. Genet Renna 2013 10.1093/hmg/ddt300 IGF-1 receptor antagonism inhibits autophagy
Neurobiol Aging Rodriguez-Martin 34 2146 2013 10.1016/j.neurobiolaging.2013.03.015 Tau phosphorylation affects its axonal transport and degradation
Neurobiol. Dis. Rodriguez-Navarro 39 423 2010 10.1016/j.nbd.2010.05.014 Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Neurobiol. Dis. Rohn 43 68 2011 10.1016/j.nbd.2010.11.003 Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
J. Neurochem. Roscic 119 398 2011 10.1111/j.1471-4159.2011.07435.x Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model
Hum. Mol. Genet. Rose 19 2144 2010 10.1093/hmg/ddq093 Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
Hum. Mol. Genet. Rothenberg 19 3219 2010 10.1093/hmg/ddq231 Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
J. Mol. Biol. Rumfeldt 385 278 2009 10.1016/j.jmb.2008.10.003 Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu,Zn superoxide dismutases
Toxicol. Appl. Pharmacol. Salabei 262 265 2012 10.1016/j.taap.2012.04.036 Verapamil stereoisomers induce antiproliferative effects in vascular smooth muscle cells via autophagy
Mol. Cell Sarbassov 22 159 2006 10.1016/j.molcel.2006.03.029 Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
Science Sardiello 325 473 2009 10.1126/science.1174447 A gene network regulating lysosomal biogenesis and function
J. Cell. Biol. Sarkar 170 1101 2005 10.1083/jcb.200504035 Lithium induces autophagy by inhibiting inositol monophosphatase
J. Biol. Chem. Sarkar 282 5641 2007 10.1074/jbc.M609532200 Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
Mol. Cell Sarkar 43 19 2011 10.1016/j.molcel.2011.04.029 Complex inhibitory effects of nitric oxide on autophagy
Hum. Mol. Genet. Sarkar 17 170 2008 10.1093/hmg/ddm294 A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
Drug Discovery Today: Technologies Sarkar 2012 Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders
Biochem. Soc. Trans. Sarkar 41 1103 2013 10.1042/BST20130134 Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
Proc. Natl. Acad. Sci. U.S.A Seglen 79 1889 1982 10.1073/pnas.79.6.1889 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
Neurobiol. Aging Sepe 35 96 2014 10.1016/j.neurobiolaging.2013.07.001 Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging
Autophagy Settembre 7 1379 2011 10.4161/auto.7.11.17166 TFEB regulates autophagy: an integrated coordination of cellular degradation and recycling processes
Science Settembre 332 1429 2011 10.1126/science.1204592 TFEB links autophagy to lysosomal biogenesis
Hum. Mol. Genet. Settembre 17 119 2008 10.1093/hmg/ddm289 A block of autophagy in lysosomal storage disorders
EMBO J. Settembre 31 1095 2012 10.1038/emboj.2012.32 A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Acta Pharmacol. Sin. Shen 34 667 2013 10.1038/aps.2012.203 Adaptive changes in autophagy after UPS impairment in Parkinson's disease
Cell Death Dis. Shi 3 e275 2012 10.1038/cddis.2012.13 Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
Br. J. Pharmacol. Shimazawa 115 1359 2012 10.1111/j.1476-5381.1995.tb16624.x Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats
Brain Siintola 129 1438 2006 10.1093/brain/awl107 Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis
Autophagy Simonsen 4 176 2008 10.4161/auto.5269 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
Neurobiol. Aging Son 33 1006.e11 2012 10.1016/j.neurobiolaging.2011.09.039 Abeta-induced formation of autophagosomes is mediated by RAGE-CaMKKbeta-AMPK signaling
PloS One Spilman 5 e9979 2010 10.1371/journal.pone.0009979 Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
Autophagy Steele 9 617 2013 10.4161/auto.23487 Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
J. Cell Biol. Takats 201 531 2013 10.1083/jcb.201211160 Autophagosomal syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila
J. Cell Biol. Tanaka 191 1367 2010 10.1083/jcb.201007013 Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Nat. Med. Tanaka 10 148 2004 10.1038/nm985 Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
Autophagy Tasdemir 4 810 2008 10.4161/auto.6486 A dual role of p53 in the control of autophagy
Nat. Cell Biol. Tasdemir 10 676 2008 10.1038/ncb1730 Regulation of autophagy by cytoplasmic p53
Autophagy Tavernarakis 4 870 2008 10.4161/auto.6730 The effects of p53 on whole organism longevity are mediated by autophagy
Autophagy Tekirdag 9 374 2013 10.4161/auto.23117 MIR181A regulates starvation-and rapamycin-induced autophagy through targeting of ATG5
Hum. Mol. Genet. Teuling 17 2849 2008 10.1093/hmg/ddn182 A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
J. Biol. Chem. Thoreen 284 8023 2009 10.1074/jbc.M900301200 An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
FASEB J. Tian 25 1934 2011 10.1096/fj.10-175158 A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway
PloS One Tizon 5 e9819 2010 10.1371/journal.pone.0009819 Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines
Proc. Natl. Acad. Sci. U.S.A Tsoi 109 13428 2012 10.1073/pnas.1204089109 CAG expansion induces nucleolar stress in polyglutamine diseases
Sci. Transl. Med. Tsunemi 142 142ra97 2012 PGC-1 rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function
Proc. Natl. Acad. Sci. U.S.A Tsvetkov 107 16982 2010 10.1073/pnas.1004498107 A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
Hum. Mol. Genet. Underwood 19 3413 2010 10.1093/hmg/ddq253 Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease
J. Biol. Chem. Vingtdeux 285 9100 2010 10.1074/jbc.M109.060061 AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
Mol. Neurobiol Wang 2013 Targeting the mTOR signaling network for Alzheimer's disease therapy
Autophagy Wang 7 966 2011 10.4161/auto.7.9.15863 Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR-and hypoxia-induced factor 1α-mediated signaling
Science Wang 338 956 2012 10.1126/science.1225967 Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
Cell. Wang 147 893 2011 10.1016/j.cell.2011.10.018 PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
Am. J. Hum. Genet. Weedon 89 308 2011 10.1016/j.ajhg.2011.07.002 Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-tooth disease
Mol. Cell Wei 30 678 2008 10.1016/j.molcel.2008.06.001 JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
Nat. Chem. Biol. Williams 4 295 2008 10.1038/nchembio.79 Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Autophagy Winslow 7 429 2011 10.4161/auto.7.4.14393 The Parkinson disease protein alpha-synuclein inhibits autophagy
Acta Pharmacol. Sin. Wu 33 743 2012 10.1038/aps.2012.14 The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1
Behav. Brain Funct. Xiong 9 13 2013 10.1186/1744-9081-9-13 The role of autophagy in Parkinson's disease: rotenone-based modeling
Brain Yang 134 258 2011 10.1093/brain/awq341 Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
Curr. Opin. Cell. Biol. Yang 22 124 2010 10.1016/j.ceb.2009.11.014 Mammalian autophagy: core molecular machinery and signaling regulation
J. Radiat. Res. Ye 51 473 2010 10.1269/jrr.10009 Resveratrol attenuates radiation damage in Caenorhabditis elegans by preventing oxidative stress
J. Biol. Chem. Yoshida 286 32651 2011 10.1074/jbc.M111.238014 Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
J. Cell Biol. Yu 171 87 2005 10.1083/jcb.200505082 Macroautophagy-a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
Autophagy Zhang 7 412 2011 10.4161/auto.7.4.14541 Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
PloS One Zhang 8 e63245 2013 10.1371/journal.pone.0063245 DRAM1 regulates autophagy flux through lysosomes
Proc. Natl. Acad. Sci. U.S.A Zhang 106 19860 2009 10.1073/pnas.0906048106 Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
J. Neurosci. Zhou 29 1773 2009 10.1523/JNEUROSCI.5685-08.2009 Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
Mol. Neurobiol Zhu 2013 10.1007/s12035-013-8457-z Autophagy modulation for Alzheimer's disease therapy
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