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RNA, v.20 no.5, 2014년, pp.621 - 631
Sperber, Henrik (Department of Chemistry, University of Washington, Seattle, Washington 98195, USA) , Beem, Alan (Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA) , Shannon, Sandra (Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA) , Jones, Ross (Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA) , Banik, Pratyusha (Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA) , Chen, Yu (Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA) , Ku, Sherman (Allen Institute for Brain Science, Seattle, Washington 98103, USA) , Varani, Gabriele (Department of Chemistry, University of Washington, Seattle, Washington 98195, USA) , Yao, Shuyuan (Allen Institute for Brain Science, Seattle, Washington 98103, USA) , Ruohola-Baker, Hannele (Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA)
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In this paper, the authors analyze how the secondary structure of primary microRNAs (pri-miRNAs) affects their processing by the Microprocessor. They show that pri-miRNAs with central mismatches in the upper stem are more sensitive to changes in Drosha level. They conclude that the secondary structu...
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