[논문]Intratympanic Steroid Injection for Bell’s Palsy: Preliminary Randomized Controlled Study

Chung, Jae Ho; Park, Chul Won; Lee, Seung Hwan; Kim, Beom Seok; Cho, Seok Hyun; Kim, Hyun Young; Kim, Seung Hyun

doi:10.1097/MAO.0000000000000505

Intratympanic Steroid Injection for Bell’s Palsy: Preliminary Randomized Controlled Study

Otology & neurotology, v.35 no.9, 2014년, pp.1673 - 1678

Chung, Jae Ho (Departments of *Otolaryngology–) , Park, Chul Won (Head and Neck Surgery and †Neurology, School of Medicine, Hanyang University, Seoul, Korea) , Lee, Seung Hwan , Kim, Beom Seok , Cho, Seok Hyun , Kim, Hyun Young , Kim, Seung Hyun

Abstract

OBJECTIVE: To investigate adjuvant effect and safety of intratympanic steroid for the treatment of Bell’s palsy. STUDY DESIGN: Prospective, investigator blinded, randomized study. SETTING: Tertiary referral center. PATIENTS: Patients who received treatment for Bell’s palsy from December 2007 to March 2011 were randomly divided into two groups. The control group (n = 17) was treated with systemic steroid plus antiviral agent, and intratympanic steroid injection group (IT group, n = 14) received intratympanic steroid injection combined with medications. Facial functions were evaluated on a regular basis up to 6 months. INTERVENTION: Intratympanic steroid injection. MAIN OUTCOME MEASURES: Facial nerve functions of initial presentation and follow-up were evaluated with House-Brackmann (H-B) system. Primary outcome was complete recovery rate of 6 months. Secondary outcomes included improvement of H-B grade within 3 weeks, time of first improvement in facial function, and cumulative recovery rate. In addition, subgroup analysis of H-B grade over than IV was performed. RESULTS: Complete recovery rate was not different between groups. Time of first improvement was shorter in IT group (p = 0.043). And IT group had a better cumulative recovery rate (p = 0.041) and showed the significant improvement in H-B grade within 3 weeks compared with control group (p = 0.045). In severe facial palsy, complete recovery rate of IT group and control group were 80% and 50% (p = 0.16), and IT groups showed the significant facial improvement within 3 weeks (p = 0.025). And there were no major adverse effects of intratympanic injection. CONCLUSION: Intratympanic steroid injection might be a safe and useful adjuvant treatment modality for Bell’s palsy.

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표제어: PCR

동의어: Packet Collision Rate

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Intratympanic Steroid Injection for Bell’s Palsy: Preliminary Randomized Controlled Study

Abstract

참고문헌 (23)

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