[논문]Effects of Korean Red Ginseng ( Panax ginseng ), urushiol ( Rhus vernicifera Stokes), and probiotics ( Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease

Bang, Chang Seok; Hong, So Hyung; Suk, Ki Tae; Kim, Jin Bong; Han, Sang Hak; Sung, Hotaik; Kim, Eun Ji; Kim, Myoung Jo; Kim, Moon Young; Baik, Soon Koo; Kim, Dong Joon

doi:10.1016/j.jgr.2014.04.002

Effects of Korean Red Ginseng ( Panax ginseng ), urushiol ( Rhus vernicifera Stokes), and probiotics ( Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease 원문보기

Journal of ginseng research = 高麗人參學會誌, v.38 no.3, 2014년, pp.167 - 172

Bang, Chang Seok (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea) , Hong, So Hyung (Department of Molecular Medicine, Hallym University College of Medicine, Chuncheon, Korea) , Suk, Ki Tae (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea) , Kim, Jin Bong (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea) , Han, Sang Hak (Department of Pathology, Hallym University College of Medicine, Chuncheon, Korea) , Sung, Hotaik (Department of Biology, Stanford University, Stanford, CA, USA) , Kim, Eun Ji (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, Korea) , Kim, Myoung Jo (College of Agriculture and Life Science, Kangwon National University, Chuncheon, Korea) , Kim, Moon Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) , Baik, Soon Koo (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) , Kim, Dong Joon (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea)

Abstract ▼ AI-Helper

BackgroundRoles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD).MethodsWe evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a Lieber–DeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared.ResultsNo between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin-1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group.ConclusionThe pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.

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참고문헌 (27)

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Effects of Korean Red Ginseng ( Panax ginseng ), urushiol ( Rhus vernicifera Stokes), and probiotics ( Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease 원문보기

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Effects of Korean Red Ginseng ( Panax ginseng ), urushiol ( Rhus vernicifera Stokes), and probiotics ( Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease 원문보기

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