최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Genes & development, v.28 no.21, 2014년, pp.2361 - 2369
Choi, Jang Hyun (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) , Choi, Sun-Sil , Kim, Eun Sun (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) , Jedrychowski, Mark P. , Yang, Yong Ryoul (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) , Jang, Hyun-Jun , Suh, Pann-Ghill (Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA) , Banks, Alexander S. , Gygi, Steven P. (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) , Spiegelman, Bruce M.
Phosphorylation of PPARγ at Ser273 by cyclin-dependent kinase 5 (CDK5) in adipose tissue stimulates insulin resistance. Choi et al. find that Thrap3 (thyroid hormone receptor-associated protein 3) can directly interact with PPARγ when it is phosphorylated at Ser273, and this interactio...
Berg AH , Combs TP , Du X , Brownlee M , Scherer PE . 2001 . The adipocyte-secreted protein Acrp30 enhances hepatic insulin action . Nat Med 7 : 947 – 953 11479628
Bray GA , Bellanger T . 2006 . Epidemiology, trends, and morbidities of obesity and the metabolic syndrome . Endocrine 29 : 109 – 117 16622298
Calle EE , Rodriguez C , Walker-Thurmond K , Thun MJ . 2003 . Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults . N Engl J Med 348 : 1625 – 1638 12711737
Chandra V , Huang P , Hamuro Y , Raghuram S , Wang Y , Burris TP , Rastinejad F . 1998 . Structure of the intact PPAR-γ–RXR–nuclear receptor complex on DNA . Nature 456 : 350 – 356 19043829
Chen JD , Evans RM . 1995 . A transcriptional co-repressor that interacts with nuclear hormone receptors . Nature 377 : 454 – 457 7566127
Choi JH , Banks AS , Estall JL , Kajimura S , Boström P , Laznik D , Ruas JL , Chalmers MJ , Kamenecka TM , Blüher M , . 2010 . Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5 . Nature 466 : 451 – 456 20651683
Choi JH , Banks AS , Kamenecka TM , Busby SA , Chalmers MJ , Kumar N , Kuruvilla DS , Shin Y , He Y , Bruning JB , . 2011 . Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation . Nature 477 : 477 – 481 21892191
Cook KS , Min HY , Johnson D , Chaplinsky RJ , Flier JS , Hunt CR , Spiegelman BM . 1987 . Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve . Science 237 : 402 – 405 3299705
DiRenzo J , Söderstrom M , Kurokawa R , Ogliastro MH , Ricote M , Ingrey S , Hörlein A , Rosenfeld MG , Glass CK . 1997 . Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors . Mol Cell Biol 17 : 2166 – 2176 9121466
Flier JS , Cook KS , Usher P , Spiegelman BM . 1987 . Severely impaired adipsin expression in genetic and acquired obesity . Science 237 : 405 – 408 3299706
Fondell JD , Ge H , Roeder RG . 1996 . Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex . Proc Natl Acad Sci 93 : 8329 – 8333 8710870
Fondell JD , Guermah M , Malik S , Roeder RG . 1999 . Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID . Proc Natl Acad Sci 96 : 1959 – 1964 10051577
Ge K , Guermah M , Yuan CX , Ito M , Wallberg AE , Spiegelman BM , Roeder RG . 2002 . Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis . Nature 417 : 563 – 567 12037571
Heyd F , Lynch KW . 2010 . Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing . Mol Cell 40 : 126 – 137 20932480
Hörlein AJ , Näär AM , Heinzel T , Torchia J , Gloss B , Kurokawa R , Ryan A , Kamei Y , Söderström M , Glass CK , . 1995 . Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor . Nature 377 : 397 – 404 7566114
Hotamisligil GS , Shargill NS , Spiegelman BM . 1993 . Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance . Science 259 : 87 – 91 7678183
Hsu IR , Kim SP , Kabir M , Bergman RN . 2007 . Metabolic syndrome, hyperinsulinemia, and cancer . Am J Clin Nutr 86 : 867 – 871
Hu E , Liang P , Spiegelman BM . 1996 . AdipoQ is a novel adipose-specific gene dysregulated in obesity . J Biol Chem 271 : 10697 – 10703 8631877
Ito M , Yuan CX , Malik S , Gu W , Fondell JD , Yamamura S , Fu ZY , Zhang X , Qin J , Roeder RG . 1999 . Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators . Mol Cell 3 : 361 – 370 10198638
Ito M , Okano HJ , Darnell RB , Roeder RG . 2002 . The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development . EMBO J 21 : 3464 – 3475 12093747
Katano-Toki A , Satoh T , Tomaru T , Yoshino S , Ishizuka T , Ishii S , Ozawa A , Shibusawa N , Tsuchiya T , Saito T , . 2013 . THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation . Mol Endocrinol 27 : 769 – 780 23525231
Kershaw EE , Flier JS . 2004 . Adipose tissue as an endocrine organ . J Clin Endocrinol Metab 89 : 2548 – 2556 15181022
Kim JY , van de Wall E , Laplante M , Azzara A , Trujillo ME , Hofmann SM , Schraw T , Durand JL , Li H , Li G , . 2007 . Obesity-associated improvements in metabolic profile through expansion of adipose tissue . J Clin Invest 117 : 2621 – 2637 17717599
Kliewer SA , Umesono K , Mangelsdorf DJ , Evans RM . 1992 . Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling . Nature 355 : 446 – 449 1310351
Kumashiro N , Beddow SA , Vatner DF , Majumdar SK , Cantley JL , Guebre-Egziabher F , Fat I , Guigni B , Jurczak MJ , Birkenfeld AL , . 2013 . Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance . Diabetes 62 : 2183 – 2194 23423574
Lagathu C , Yvan-Charvet L , Bastard JP , Maachi M , Quignard-Boulangé A , Capeau J , Caron M . 2006 . Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes . Diabetologia 49 : 2162 – 2173 16865359
Lande-Diner L , Boyault C , Kim JY , Weitz CJ . 2013 . A positive feedback loop links circadian clock factor CLOCK–BMAL1 to the basic transcriptional machinery . Proc Natl Acad Sci 110 : 16021 – 16026 24043798
Lehmann JM , Moore LB , Smith-Oliver TA , Wilkison WO , Willson TM , Kliewer SA . 1995 . An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ) . J Biol Chem 270 : 12953 – 12956 7768881
Li P , Fan W , Xu J , Lu M , Yamamoto H , Auwerx J , Sears DD , Talukdar S , Oh D , Chen A , . 2011 . Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity . Cell 147 : 815 – 826 22078880
Lipscombe LL , Gomes T , Lévesque LE , Hux JE , Juurlink DN , Alter DA . 2007 . Thiazolidinediones and cardiovascular outcomes in older patients with diabetes . JAMA 298 : 2634 – 2643 18073359
Lo JC , Ljubicic S , Leibiger B , Kern M , Leibiger IB , Moede T , Kelly ME , Chatterjee Bhowmick D , Murano I , Cohen P , . 2014 . Adipsin is an adipokine that improves β cell function in diabetes . Cell 158 : 41 – 53 24995977
Maeda N , Shimomura I , Kishida K , Nishizawa H , Matsuda M , Nagaretani H , Furuyama N , Kondo H , Takahashi M , Arita Y , . 2002 . Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 . Nat Med 8 : 731 – 737 12068289
Mangelsdorf DJ , Evans RM . 1995 . The RXR heterodimers and orphan receptors . Cell 83 : 841 – 850 8521508
Mokdad AH , Ford ES , Bowman BA , Dietz WH , Vinicor F , Bales VS , Marks JS . 2001 . Prevalence of obesity, diabetes, and obesity-related health risk factors . JAMA 289 : 76 – 79 12503980
Nesto RW , Bell D , Bonow RO , Fonseca V , Grundy SM , Horton ES , Le Winter M , Porte D , Semenkovich CF , Smith S , . 2004 . Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association . Diabetes Care 27 : 256 – 263 14693998
Nolte RT , Wisely GB , Westin S , Cobb JE , Lambert MH , Kurokawa R , Rosenfeld MG , Willson TM , Glass CK , Milburn MV . 1998 . Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ . Nature 395 : 137 – 143 9744270
Puigserver P , Wu Z , Park CW , Graves R , Wright M , Spiegelman BM . 1998 . A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis . Cell 92 : 829 – 839 9529258
Rosen ED , Spiegelman BM . 2014 . What we talk about when we talk about fat . Cell 156 : 20 – 44 24439368
Rosen BS , Cook KS , Yaglom J , Groves DL , Volanakis JE , Damm D , White T , Spiegelman BM . 1989 . Adipsin and complement factor D activity: an immune-related defect in obesity . Science 244 : 1483 – 1487 2734615
Tontonoz P , Spiegelman BM . 2008 . Fat and beyond: the diverse biology of PPARγ . Annu Rev Biochem 77 : 289 – 312 18518822
Tontonoz P , Hu E , Spiegelman BM . 1994 . Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor . Cell 79 : 1147 – 1156 8001151
Trujillo ME , Scherer PE . 2006 . Adipose tissue-derived factors: impact on health and disease . Endocr Rev 27 : 762 – 778 17056740
Unger RH . 2002 . Lipotoxic diseases . Annu Rev Med 53 : 319 – 336 11818477
Van Gaal LF , Mertens IL , De Block CE . 2006 . Mechanisms linking obesity with cardiovascular disease . Nature 444 : 875 – 880 17167476
Watts LM , Manchem VP , Leedom TA , Rivard AL , McKay RA , Bao D , Neroladakis T , Monia BP , Bodenmiller DM , Cao JX , . 2005 . Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism . Diabetes 54 : 1846 – 1853 15919808
Willson TM , Lambert MH , Kliewer SA . 2001 . Peroxisome proliferator-activated receptor γ and metabolic disease . Annu Rev Biochem 70 : 341 – 367 11395411
Yamauchi T , Kamon J , Waki H , Terauchi Y , Kubota N , Hara K , Mori Y , Ide T , Murakami K , Tsuboyama-Kasaoka N , . 2001 . The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity . Nat Med 7 : 941 – 946 11479627
Yuan CX , Ito M , Fondell JD , Fu ZY , Roeder RG . 1998 . The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion . Proc Natl Acad Sci 95 : 7939 – 7944 9653119
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.