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[해외논문] Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming 원문보기

Genes & development, v.28 no.21, 2014년, pp.2361 - 2369  

Choi, Jang Hyun (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) ,  Choi, Sun-Sil ,  Kim, Eun Sun (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) ,  Jedrychowski, Mark P. ,  Yang, Yong Ryoul (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) ,  Jang, Hyun-Jun ,  Suh, Pann-Ghill (Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA) ,  Banks, Alexander S. ,  Gygi, Steven P. (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea) ,  Spiegelman, Bruce M.

Abstract AI-Helper 아이콘AI-Helper

Phosphorylation of PPARγ at Ser273 by cyclin-dependent kinase 5 (CDK5) in adipose tissue stimulates insulin resistance. Choi et al. find that Thrap3 (thyroid hormone receptor-associated protein 3) can directly interact with PPARγ when it is phosphorylated at Ser273, and this interactio...

주제어

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