[논문]The influence of the Korean traditional Chungkookjang on variables of metabolic syndrome in overweight/obese subjects: study protocol

Back, Hyang-Im; Ha, Ki-Chan; Kim, Hye-Mi; Kim, Min-Gul; Yu, Ok-Kyeong; Byun, Moon-Sun; Jeong, Do-Youn; Jeong, Seong-Yeop; Cha, Youn-Soo; Park, Tae-Sun

doi:10.1186/1472-6882-13-297

The influence of the Korean traditional Chungkookjang on variables of metabolic syndrome in overweight/obese subjects: study protocol 원문보기

Bmc complementary and alternative medicine, v.13, 2013년, pp.297 - 297

Back, Hyang-Im (Healthcare Claims & Management Incorporation, 758 Baekie-daero, Deokin-gu, Jeonju, Jeonbuk 561-832, Republic of Korea) , Ha, Ki-Chan (Healthcare Claims & Management Incorporation, 758 Baekie-daero, Deokin-gu, Jeonju, Jeonbuk 561-832, Republic of Korea) , Kim, Hye-Mi (Healthcare Claims & Management Incorporation, 758 Baekie-daero, Deokin-gu, Jeonju, Jeonbuk 561-832, Republic of Korea) , Kim, Min-Gul (Clinical Trial Center, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk 561-712, Republic of Korea) , Yu, Ok-Kyeong (Department of Food Science and Human Nutrition, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea) , Byun, Moon-Sun (Department of Food Science and Human Nutrition, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea) , Jeong, Do-Youn (Sunchang Research Center for Fermentation Microbes, 61-27 Minsongmaeul-gil, Sunchang-eup, Sunchang, Jeonbuk 595-804, Republic of Korea) , Jeong, Seong-Yeop (Sunchang Research Center for Fermentation Microbes, 61-27 Minsongma) , Cha, Youn-Soo , Park, Tae-Sun

Abstract ▼ AI-Helper

BackgroundMetabolic syndrome is a set of disorders that increases the risk of developing cardiovascular disease. The primary target of treatment of patients with metabolic syndrome is therapeutic lifestyle change. Numerous preclinical study have reported positive effects of chungkookjang in in vivo models of diabetes and obesity, but there is a paucity of controlled clinical trials on variables of metabolic syndrome in obese subjects. Thus, the objective of this trial is to examine the effect of chungkookjang compared to placebo on variables of metabolic syndrome in overweight/obese subjects.MethodsThis double-blind randomized controlled crossover trial will be conducted on 120 overweight/obese subjects; aged 19–29 years. Subjects will be recruited from the Chonbuk National University, Jeonju, South Korea. Enrolled subjects will be randomly assigned to two groups of equal number; one group received 35 g of chungkookjang (n = 60) and the other group received placebo (n = 60) on a regular daily basis for 12 weeks. After a 12-week washout period, the groups will be crossed over. In addition to anthropometric measures and blood pressure, glucose parameter, lipid profile, adipocytokine, and carnitine assay will be determined at baseline and 12 week. Also, safety will be assessing by measuring total bilirubin, alkaline phosphatase, alanine transaminase, aspartate aminotransferase, total protein, albumin, blood urea nitrogen, creatinine, and creatine kinase at baseline and 12 weeks. 24-hour dietary recalls were collected at the baseline and at the end of the trial.DiscussionThis trial will evaluate the effects of chungkookjang on variables of metabolic syndrome in overweight/obese subjects. The results of this study may contribute to the reduction of risk factor for metabolic syndrome caused by obesity.Trial registrationClinical trials NCT01811511.

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참고문헌 (19)

Withrow D Alter DA The economic burden of obesity worldwide: a systematic review of the direct costs of obesity Obesity Rev 2011 12 2 131 141 10.1111/j.1467-789X.2009.00712.x

상세보기
Flegal KM Carroll MD Kit BK Ogden CL Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010 JAMA 2012 307 5 491 497 10.1001/jama.2012.39 22253363

상세보기
Choi H Song S Kim J Chung J Yoon J Paik HY Song Y High carbohydrate intake was inversely associated with high-density lipoprotein cholesterol among Korean adults Nutrition Res 2012 32 2 100 106 10.1016/j.nutres.2011.12.013 22348458

상세보기
Park SS Yoon YS Oh SW Health-related quality of life in metabolic syndrome: The Korea National Health and Nutrition Examination Survey 2005 Diabetes Res Clin Pract 2011 91 381 388 10.1016/j.diabres.2010.11.010 21134699

상세보기
Bitsori M Kafatos A Dysmetabolic syndrome in childhood and adolescence Acta paediatrica 2005 94 8 995 1005 10.1080/08035250510029532 16188838

상세보기
Cruz ML Goran MI The metabolic syndrome in children and adolescents Curr Diab Reports 2004 4 1 53 62 10.1007/s11892-004-0012-x

상세보기
Knowler WC Barrett-Connor E Fowler SE Hamman RF Lachin JM Walker EA Nathan DM Diabetes Prevention Program Research G Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin New Eng J Med 2002 346 6 393 403 11832527
Marwick TH Hordern MD Miller T Chyun DA Bertoni AG Blumenthal RS Philippides G Rocchini A Council on Clinical Cardiology AHAECR, Prevention C Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association Circulation 2009 119 25 3244 3262 10.1161/CIRCULATIONAHA.109.192521 19506108

상세보기
Nanri A Mizoue T Takahashi Y Kirii K Inoue M Tsugane S MN Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women J Nutr 2010 140 580 586 10.3945/jn.109.116020 20053935

상세보기
Kwon SH Lee KB Im KS Kim SO Park KY Weight reduction and lipid lowering effects of Korean traditional soybean fermented products J Korean Soc Food Sci Nutr 2006 35 9 1194 1199
Lee CU Koh JB Effects of Cheonggukjang on lipid metabolism in female rats fed cholesterol diet J Life Sci 2006 16 932 937
Yang HJ Kim HJ Kim MJ Kang S da Kim S Daily JW Jeong do Y Kwon DY Park S Standardized chungkookjang, short-term fermented soybeans with Bacillus lichemiformis, improves glucose homeostasis as much as traditionally made chungkookjang in diabetic rats J Clin Biochem Nutr 2013 52 1 49 57 10.3164/jcbn.12-54 23341698

상세보기
Kwon DY Daily JW 3rd Kim HJ Park S Antidiabetic effects of fermented soybean products on type 2 diabetes Nutr Res 2010 30 1 1 13 10.1016/j.nutres.2009.11.004 20116654

상세보기
Choi YH Lim H Heo MY Kwon DY Kim HP Anti-inflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition J Med Food 2008 11 3 539 543 10.1089/jmf.2007.0125 18800904

상세보기
Kim DJ Jeong YJ Kwon JH Moon KD Kim HJ Jeon SM Lee MK Park YB Choi MS Beneficial effect of chungkukjang on regulating blood glucose and pancreatic beta-cell functions in C75BL/KsJ-db/db mice J Med Food 2008 11 2 215 223 10.1089/jmf.2007.560 18598161

상세보기
Kwon DY Hong SM Lee JE Sung SR Park S Long-term consumption of fermented soybean-derived Chungkookjang attenuates hepatic insulin resistance in 90% pancreatectomized diabetic rats Horm Metab Res 2007 39 10 752 757 10.1055/s-2007-990287 17952839

상세보기
Kwon DY Jang JS Hong SM Lee JE Sung SR Park HR Park S Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats Eur J Nutr 2007 46 1 44 52 10.1007/s00394-006-0630-y 17200876

상세보기
Kwon DY Jang JS Lee JE Kim YS Shin DH Park S The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator-activated receptor-gamma activity in vitro Bio Factors 2006 26 4 245 258
Back HI Kim SR Yang JA Kim MG Chae SW Cha YS Effects of Chungkookjang supplementation on obesity and atherosclerotic indices in overweight/obese subjects: a 12-week, randomized, double-blind, placebo-controlled clinical trial J Med Food 2011 14 5 532 537 10.1089/jmf.2010.1199 21434780

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The influence of the Korean traditional Chungkookjang on variables of metabolic syndrome in overweight/obese subjects: study protocol 원문보기

Abstract ▼ AI-Helper

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