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Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences 원문보기

Current opinion in cell biology, v.33, 2015년, pp.125 - 131  

Shi, Lei (Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038) ,  Tu, Benjamin P. (Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038)

Abstract AI-Helper 아이콘AI-Helper

Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic pathways and transformations. Emerging evidence reveals that cells monitor the levels of acetyl-CoA as a key indicator of their metabolic state, through distinctive protein acetylation modifications dependent ...

참고문헌 (65)

  1. 1 Wellen KE Thompson CB A two-way street: reciprocal regulation of metabolism and signalling Nat Rev Mol Cell Biol 2012 13 270 276 22395772 

  2. 2 Kaelin WG Jr McKnight SL Influence of metabolism on epigenetics and disease Cell 2013 153 56 69 23540690 

  3. 3 Hardie DG AMPK: positive and negative regulation, and its role in whole-body energy homeostasis Curr Opin Cell Biol 2014 33C 1 7 25259783 

  4. 4 Canto C Auwerx J NAD+ as a signaling molecule modulating metabolism Cold Spring Harb Symp Quant Biol 2011 76 291 298 22345172 

  5. 5 Houtkooper RH Canto C Wanders RJ Auwerx J The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways Endocr Rev 2010 31 194 223 20007326 

  6. 6 Theodoulou FL Sibon OC Jackowski S Gout I Coenzyme A and its derivatives: renaissance of a textbook classic Biochem Soc Trans 2014 42 1025 1032 25109997 

  7. 7 Srere PA The citrate cleavage enzyme. I. Distribution and purification J Biol Chem 1959 234 2544 2547 13833535 

  8. 8 Srere PA The molecular physiology of citrate Nature 1965 205 766 770 

  9. 9 Wellen KE Hatzivassiliou G Sachdeva UM Bui TV Cross JR Thompson CB ATP-citrate lyase links cellular metabolism to histone acetylation Science 2009 324 1076 1080 19461003 

  10. 10 Takahashi H McCaffery JM Irizarry RA Boeke JD Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription Mol Cell 2006 23 207 217 16857587 

  11. 11 Cai L Sutter BM Li B Tu BP Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes Mol Cell 2011 42 426 437 21596309 Study showing how and why some acetylation modifications are coupled to acetyl-CoA fluctuations in yeast. 

  12. 12 Shi L Tu BP Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae Proc Natl Acad Sci U S A 2013 110 7318 7323 23589851 

  13. 13 McGarry JD Foster DW Regulation of hepatic fatty acid oxidation and ketone body production Annu Rev Biochem 1980 49 395 420 6157353 

  14. 14 Jackowski S Leonardi R Deregulated coenzyme A loss of metabolic flexibility and diabetes Biochem Soc Trans 2014 42 1118 1122 25110012 

  15. 15 Leonardi R Rehg JE Rock CO Jackowski S Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state PLoS One 2010 5 e11107 20559429 

  16. 16 Robinson AM Williamson DH Physiological roles of ketone bodies as substrates and signals in mammalian tissues Physiol Rev 1980 60 143 187 6986618 

  17. 17 Lin R Tao R Gao X Li T Zhou X Guan KL Xiong Y Lei QY Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth Mol Cell 2013 51 506 518 23932781 

  18. 18 Uyeda K Repa JJ Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis Cell Metab 2006 4 107 110 16890538 

  19. 19 Eisenberg T Schroeder S Andryushkova A Pendl T Kuttner V Bhukel A Marino G Pietrocola F Harger A Zimmermann A Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan Cell Metab 2014 19 431 444 24606900 One of two studies identifying acetyl-CoA as a repressor of autophagy. The authors demonstrated nucleocytosolic acetyl-CoA repressed autophagy and ATG7 gene expression in yeast. 

  20. 20 Marino G Pietrocola F Eisenberg T Kong Y Malik SA Andryushkova A Schroeder S Pendl T Harger A Niso-Santano M Regulation of autophagy by cytosolic acetyl-coenzyme A Mol Cell 2014 53 710 725 24560926 

  21. 21 Tu BP Kudlicki A Rowicka M McKnight SL Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes Science 2005 310 1152 1158 16254148 

  22. 22 Tu BP Mohler RE Liu JC Dombek KM Young ET Synovec RE McKnight SL Cyclic changes in metabolic state during the life of a yeast cell Proc Natl Acad Sci U S A 2007 104 16886 16891 17940006 

  23. 23 Gasch AP Spellman PT Kao CM Carmel-Harel O Eisen MB Storz G Botstein D Brown PO Genomic expression programs in the response of yeast cells to environmental changes Mol Biol Cell 2000 11 4241 4257 11102521 

  24. 24 Brauer MJ Huttenhower C Airoldi EM Rosenstein R Matese JC Gresham D Boer VM Troyanskaya OG Botstein D Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast Mol Biol Cell 2008 19 352 367 17959824 

  25. 25 Kuang Z Cai L Zhang X Ji H Tu BP Boeke JD High-temporal-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast Nat Struct Mol Biol 2014 21 854 863 25173176 

  26. 26 Mehrotra S Galdieri L Zhang T Zhang M Pemberton LF Vancura A Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism Biochim Biophys Acta 2014 1839 751 763 24907648 

  27. 27 Shi L Tu BP Protein acetylation as a means to regulate protein function in tune with metabolic state Biochem Soc Trans 2014 42 1037 1042 25109999 

  28. 28 Cai L Tu BP On Acetyl-CoA as a Gauge of Cellular Metabolic State Cold Spring Harb Symp Quant Biol 2011 76 195 202 21900151 

  29. 29 Lipmann F Tuttle LC The detection of activated carboxyl groups with hydroxylamine as interceptor J Biol Chem 1945 161 415 21005751 

  30. 30 Jones ME Lipmann F Hilz H Lynen F On the enzymatic mechanism of Coenzyme A acetylation with adenosine triphosphate and acetate J Am Chem Soc 1953 75 3285 3286 

  31. 31 Berg P Acyl adenylates, an enzymatic mechanism of acetate activation J Biol Chem 1956 222 991 1013 13367067 

  32. 32 Starai VJ Celic I Cole RN Boeke JD Escalante-Semerena JC Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine Science 2002 298 2390 2392 12493915 

  33. 33 Hallows WC Lee S Denu JM Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases Proc Natl Acad Sci U S A 2006 103 10230 10235 16790548 

  34. 34 Schwer B Bunkenborg J Verdin RO Andersen JS Verdin E Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 Proc Natl Acad Sci U S A 2006 103 10224 10229 16788062 

  35. 35 Kim SC Sprung R Chen Y Xu Y Ball H Pei J Cheng T Kho Y Xiao H Xiao L Substrate and functional diversity of lysine acetylation revealed by a proteomics survey Mol Cell 2006 23 607 618 16916647 The first proteomic survey demonstrating that acetylation can occur on a variety of proteins, especially mitochondrial proteins. 

  36. 36 Choudhary C Kumar C Gnad F Nielsen ML Rehman M Walther TC Olsen JV Mann M Lysine acetylation targets protein complexes and co-regulates major cellular functions Science 2009 325 834 840 19608861 

  37. 37 Wang Q Zhang Y Yang C Xiong H Lin Y Yao J Li H Xie L Zhao W Yao Y Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux Science 2010 327 1004 1007 20167787 

  38. 38 Zhao S Xu W Jiang W Yu W Lin Y Zhang T Yao J Zhou L Zeng Y Li H Regulation of cellular metabolism by protein lysine acetylation Science 2010 327 1000 1004 20167786 

  39. 39 Guan KL Xiong Y Regulation of intermediary metabolism by protein acetylation Trends Biochem Sci 2011 36 108 116 20934340 

  40. 40 Hallows WC Yu W Denu JM Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation J Biol Chem 2012 287 3850 3858 22157007 

  41. 41 Cai L McCormick MA Kennedy BK Tu BP Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1 Cell Rep 2013 4 1063 1071 24035395 

  42. 42 Baeza J Dowell JA Smallegan MJ Fan J Amador-Noguez D Khan Z Denu JM Stoichiometry of site-specific lysine acetylation in an entire proteome J Biol Chem 2014 289 21326 21338 24917678 

  43. 43 Weinert BT Iesmantavicius V Moustafa T Scholz C Wagner SA Magnes C Zechner R Choudhary C Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae Mol Syst Biol 2014 10 716 24489116 

  44. 44 Paik WK Pearson D Lee HW Kim S Nonenzymatic acetylation of histones with acetyl-CoA Biochim Biophys Acta 1970 213 513 522 5534125 

  45. 45 Berndsen CE Denu JM Assays for mechanistic investigations of protein/histone acetyltransferases Methods 2005 36 321 331 16085424 

  46. 46 Pougovkina O te Brinke H Ofman R van Cruchten AG Kulik W Wanders RJ Houten SM de Boer VC Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation Hum Mol Genet 2014 23 3513 3522 24516071 

  47. 47 Pougovkina O Te Brinke H Wanders RJ Houten SM de Boer VC Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism J Inherit Metab Dis 2014 37 709 714 24531926 Study showing aberrant protein acylation in several models of inborn errors of metabolism associated with accumulation of particular acyl-CoA metabolites. 

  48. 48 Wagner GR Payne RM Widespread and enzyme-independent Nepsilon-acetylation and Nepsilon-succinylation of proteins in the chemical conditions of the mitochondrial matrix J Biol Chem 2013 288 29036 29045 23946487 

  49. 49 Ghanta S Grossmann RE Brenner C Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications Crit Rev Biochem Mol Biol 2013 48 561 574 24050258 

  50. 50 Neumann H Peak-Chew SY Chin JW Genetically encoding N(epsilon)-acetyllysine in recombinant proteins Nat Chem Biol 2008 4 232 234 18278036 

  51. 51 Huang R Holbert MA Tarrant MK Curtet S Colquhoun DR Dancy BM Dancy BC Hwang Y Tang Y Meeth K Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation J Am Chem Soc 2010 132 9986 9987 20608637 

  52. 52 Dancy BC Ming SA Papazyan R Jelinek CA Majumdar A Sun Y Dancy BM Drury WJ 3rd Cotter RJ Taverna SD Azalysine analogues as probes for protein lysine deacetylation and demethylation J Am Chem Soc 2012 134 5138 5148 22352831 

  53. 53 He W Newman JC Wang MZ Ho L Verdin E Mitochondrial sirtuins: regulators of protein acylation and metabolism Trends Endocrinol Metab 2012 23 467 476 22902903 

  54. 54 Wagner GR Hirschey MD Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases Mol Cell 2014 54 5 16 24725594 Review discussing evidence supporting a role for sirtuins in protein quality control and the removal of nonenzymatic protein acylation modifications. 

  55. 55 Hirschey MD Shimazu T Goetzman E Jing E Schwer B Lombard DB Grueter CA Harris C Biddinger S Ilkayeva OR SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation Nature 2010 464 121 125 20203611 

  56. 56 Lombard DB Alt FW Cheng HL Bunkenborg J Streeper RS Mostoslavsky R Kim J Yancopoulos G Valenzuela D Murphy A Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation Mol Cell Biol 2007 27 8807 8814 17923681 

  57. 57 Ahn BH Kim HS Song S Lee IH Liu J Vassilopoulos A Deng CX Finkel T A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis Proc Natl Acad Sci U S A 2008 105 14447 14452 18794531 

  58. 58 Du J Zhou Y Su X Yu JJ Khan S Jiang H Kim J Woo J Kim JH Choi BH Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase Science 2011 334 806 809 22076378 Inspired by protein structural analysis, the authors discovered the lysine demalonylase and desuccinylase activity of SIRT5. This study explains why SIRT5 did not exhibit deacetylase activity and implicates other sirtuin members in regulating various protein acylation modifications other than acetylation. 

  59. 59 Jiang H Khan S Wang Y Charron G He B Sebastian C Du J Kim R Ge E Mostoslavsky R SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine Nature 2013 496 110 113 23552949 The authors discovered the specific role of SIRT6 in antagonizing protein lysine long chain fatty acylation by enzymology and structural analysis. This study resolves how SIRT6 regulates TNFα. 

  60. 60 Tan M Peng C Anderson KA Chhoy P Xie Z Dai L Park J Chen Y Huang H Zhang Y Lysine glutarylation is a protein posttranslational modification regulated by SIRT5 Cell Metab 2014 19 605 617 24703693 

  61. 61 Feldman JL Baeza J Denu JM Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins J Biol Chem 2013 288 31350 31356 24052263 The authors profiled distinct but overlapping deacylation specificities of sirtuins and suggested potential regulation of SIRT6 by long chain fatty acids. The results reveal distinct regulations and roles for each sirtuin in response to cellular metabolic state. 

  62. 62 de Ruijter AJ van Gennip AH Caron HN Kemp S van Kuilenburg AB Histone deacetylases (HDACs): characterization of the classical HDAC family Biochem J 2003 370 737 749 12429021 

  63. 63 Imai S Guarente L NAD+ and sirtuins in aging and disease Trends Cell Biol 2014 24 464 471 24786309 

  64. 64 Houtkooper RH Pirinen E Auwerx J Sirtuins as regulators of metabolism and healthspan Nat Rev Mol Cell Biol 2012 13 225 238 22395773 

  65. 65 Tong L Denu JM Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose Biochim Biophys Acta 2010 1804 1617 1625 20176146 

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