다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
The FEBS journal, v.282 no.11, 2015년, pp.2076 - 2088
Seirafi, Marjan (Department of Biochemistry and the Groupe de Recherche axé) , Kozlov, Guennadi (sur la Structure des Proté) , Gehring, Kalle (ines, McGill University Montré)
AI-Helper
Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson’s disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway. H...
Venderova K Park DS Programmed cell death in Parkinson’s disease Cold Spring Harb Perspect Med 2012 2 pii: a009365
Valente EM Abou-Sleiman PM Caputo V Muqit MM Harvey K Gispert S Ali Z Del Turco D Bentivoglio AR Healy DG Hereditary early-onset Parkinson’s disease caused by mutations in PINK1 Science 2004 304 1158 1160 15087508
Narendra D Walker JE Youle R Mitochondrial quality control mediated by PINK1 and parkin: links to parkinsonism Cold Spring Harb Perspect Biol 2012 4 pii: a011338
Lazarou M Jin SM Kane LA Youle RJ Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase parkin Dev Cell 2012 22 320 333 22280891
Deas E Plun-Favreau H Gandhi S Desmond H Kjaer S Loh SHY Renton AEM Harvey RJ Whitworth AJ Martins LM PINK1 cleavage at position A103 by the mitochondrial protease PARL Hum Mol Genet 2011 20 867 879 21138942
Greene AW Grenier K Aguileta MA Muise S Farazifard R Haque ME McBride HM Park DS Fon EA Mitochondrial processing peptidase regulates PINK1 processing, import and parkin recruitment EMBO Rep 2012 13 378 385 22354088
Jin SM Lazarou M Wang CX Kane LA Narendra DP Youle RJ Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL J Cell Biol 2010 191 933 942 21115803
Whitworth AJ Lee JR Ho VMW Flick R Chowdhury R McQuibban GA Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and parkin Dis Model Mech 2008 1 168 174 19048081
Yamano K Youle RJ PINK1 is degraded through the N-end rule pathway Autophagy 2013 9 1758 1769 24121706
Lin W Kang UJ Characterization of PINK1 processing, stability, and subcellular localization J Neurochem 2008 106 464 474 18397367
Zhou C Huang Y Shao YF May J Prou D Perier C Dauer W Schon EA Przedborski S The kinase domain of mitochondrial PINK1 faces the cytoplasm Proc Natl Acad Sci USA 2008 105 12022 12027 18687899
Narendra DP Jin SM Tanaka A Suen DF Gautier CA Shen J Cookson MR Youle RJ PINK1 is selectively stabilized on impaired mitochondria to activate parkin PLoS Biol 2010 8 e1000298 20126261
Geisler S Holmstrom KM Skujat D Fiesel FC Rothfuss OC Kahle PJ Springer W PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Nat Cell Biol 2010 12 119 131 20098416
Matsuda N Sato S Shiba K Okatsu K Saisho K Gautier CA Sou Y Saiki S Kawajiri S Sato F PINK1 stabilized by mitochondrial depolarization recruits parkin to damaged mitochondria and activates latent parkin for mitophagy J Cell Biol 2010 189 211 221 20404107
Vives-Bauza C Zhou C Huang Y Cui M de Vries RLA Kim J May J Tocilescu MA Liu WC Ko HS PINK1-dependent recruitment of parkin to mitochondria in mitophagy Proc Natl Acad Sci USA 2010 107 378 383 19966284
Hershko A Ciechanover A The ubiquitin system Annu Rev Biochem 1998 67 425 479 9759494
Randow F Youle RJ Self and nonself: how autophagy targets mitochondria and bacteria Cell Host Microbe 2014 15 403 411 24721569
Komander D Rape M The ubiquitin code Annu Rev Biochem 2012 81 203 229 22524316
Dye BT Schulman BA Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins Annu Rev Biophys Biomol Struct 2007 36 131 150 17477837
Berndsen CE Wolberger C New insights into ubiquitin E3 ligase mechanism Nat Struct Mol Biol 2014 21 301 307 24699078
Lazarou M Narendra DP Jin SM Tekle E Banerjee S Youle RJ PINK1 drives parkin self-association and HECT-like E3 activity upstream of mitochondrial binding J Cell Biol 2013 200 163 172 23319602
Wenzel DM Lissounov A Brzovic PS Klevit RE UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids Nature 2011 474 105 108 21532592
Chan NC Salazar AM Pham AH Sweredoski MJ Kolawa NJ Graham RL Hess S Chan DC Broad activation of the ubiquitin-proteasome system by parkin is critical for mitophagy Hum Mol Genet 2011 20 1726 1737 21296869
Sarraf SA Raman M Guarani-Pereira V Sowa ME Huttlin EL Gygi SP Harper JW Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization Nature 2013 496 372 376 23503661
Ordureau A Sarraf SA Duda DM Heo JM Jedrychowski MP Sviderskiy VO Olszewski JL Koerber JT Xie T Beausoleil SA Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis Mol Cell 2014 56 360 375 25284222
Durcan TM Tang MY Perusse JR Dashti EA Aguileta MA McLelland GL Gros P Shaler TA Faubert D Coulombe B USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin EMBO J 2014 33 2473 2491 25216678
Chaugule VK Burchell L Barber KR Sidhu A Leslie SJ Shaw GS Walden H Autoregulation of parkin activity through its ubiquitin-like domain EMBO J 2011 30 2853 2867 21694720
Riley BE Lougheed JC Callaway K Velasquez M Brecht E Nguyen L Shaler T Walker D Yang Y Regnstrom K Structure and function of parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases Nat Commun 2013 4 1982 23770887
Trempe JF Sauve V Grenier K Seirafi M Tang MY Menade M Al-Abdul-Wahid S Krett J Wong K Kozlov G Structure of parkin reveals mechanisms for ubiquitin ligase activation Science 2013 340 1451 1455 23661642
Wauer T Komander D Structure of the human parkin ligase domain in an autoinhibited state EMBO J 2013 32 2099 2112 23727886
Fallon L Belanger CML Corera AT Kontogiannea M Regan-Klapisz E Moreau F Voortman J Haber M Rouleau G Thorarinsdottir T A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3) K-Akt signalling Nat Cell Biol 2006 8 834 842 16862145
Spratt DE Walden H Shaw GS RBR E3 ubiquitin ligases: new structures, new insights, new questions Biochem J 2014 458 421 437 24576094
Cruts M Theuns J Van Broeckhoven C Locus-specific mutation databases for neurodegenerative brain diseases Hum Mutat 2012 33 1340 1344 22581678
Finney N Walther F Mantel PY Stauffer D Rovelli G Dev KK The cellular protein level of parkin is regulated by its ubiquitin-like domain J Biol Chem 2003 278 16054 16058 12621021
Sakata E Yamaguchi Y Kurimoto E Kikuchi J Yokoyama S Yamada S Kawahara H Yokosawa H Hattori N Mizuno Y Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain EMBO Rep 2003 4 301 306 12634850
Trempe JF Chen CXQ Grenier K Camacho EM Kozlov G McPherson PS Gehring K Fon EA SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination Mol Cell 2009 36 1034 1047 20064468
Bai JJ Safadi SS Mercier P Barber KR Shaw GS Ataxin-3 is a multivalent ligand for the parkin Ubl domain Biochemistry 2013 52 7369 7376 24063750
Spratt DE Martinez-Torres RJ Noh YJ Mercier P Manczyk N Barber KR Aguirre JD Burchell L Purkiss A Walden H A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease Nat Commun 2013 4 1983 23770917
Dove KK Klevit RE Structural biology: parkin’s serpentine shape revealed in the year of the snake Curr Biol 2013 23 R691 R693 23968926
Hristova VA Beasley SA Rylett RJ Shaw GS Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile parkinson-related E3 ligase parkin J Biol Chem 2009 284 14978 14986 19339245
Regnstrom K Yan J Nguyen L Callaway K Yang Y Diep L Xing W Adhikari A Beroza P Hom RK Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target PLoS ONE 2013 8 e66879 23861750
Beasley SA Hristova VA Shaw GS Structure of the parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson’s disease Proc Natl Acad Sci USA 2007 104 3095 3100 17360614
Duda DM Olszewski JL Schuermann JP Kurinov I Miller DJ Nourse A Alpi AF Schulman BA Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an ariadne-family E3 and insights into ligation mechanism Structure 2013 21 1030 1041 23707686
Stieglitz B Rana RR Koliopoulos MG Morris-Davies AC Schaeffer V Christodoulou E Howell S Brown NR Dikic I Rittinger K Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP Nature 2013 503 422 426 24141947
Stieglitz B Morris-Davies AC Koliopoulos MG Christodoulou E Rittinger K LUBAC synthesizes linear ubiquitin chains via a thioester intermediate EMBO Rep 2012 13 840 846 22791023
Madegowda RH Kishore A Anand A Mutational screening of the parkin gene among South Indians with early onset Parkinson’s disease J Neurol Neurosurg Psychiatry 2005 76 1588 1590 16227559
Ziviani E Tao RN Whitworth AJ Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin Proc Natl Acad Sci USA 2010 107 5018 5023 20194754
Iguchi M Kujuro Y Okatsu K Koyano F Kosako H Kimura M Suzuki N Uchiyama S Tanaka K Matsuda N Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation J Biol Chem 2013 288 22019 22032 23754282
Okatsu K Oka T Iguchi M Imamura K Kosako H Tani N Kimura M Go E Koyano F Funayama M PINK1 autophosphorylation upon membrane potential dissipation is essential for parkin recruitment to damaged mitochondria Nat Commun 2012 3 1016 22910362
Kondapalli C Kazlauskaite A Zhang N Woodroof HI Campbell DG Gourlay R Burchell L Walden H Macartney TJ Deak M PINK1 is activated by mitochondrial membrane potential depolarization and stimulates parkin E3 ligase activity by phosphorylating Serine 65 Open Biol 2012 2 120080 22724072
Koyano F Okatsu K Kosako H Tamura Y Go E Kimura M Kimura Y Tsuchiya H Yoshihara H Hirokawa T Ubiquitin is phosphorylated by PINK1 to activate parkin Nature 2014 510 162 166 24784582
Kazlauskaite A Kondapalli C Gourlay R Campbell DG Ritorto MS Hofmann K Alessi DR Knebel A Trost M Muqit MMK Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65) Biochem J 2014 460 127 139 24660806
Kane LA Lazarou M Fogel AI Li Y Yamano K Sarraf SA Banerjee S Youle RJ PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity J Cell Biol 2014 205 143 153 24751536
Shiba-Fukushima K Arano T Matsumoto G Inoshita T Yoshida S Ishihama Y Ryu KY Nukina N Hattori N Imai Y Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes parkin mitochondrial tethering PLoS Genet 2014 10 e1004861 25474007
Wauer T Swatek KN Wagstaff JL Gladkova C Pruneda JN Michel MA Gersch M Johnson CM Freund SM Komander D Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis EMBO J 2015 34 307 325 25527291
Zheng XD Hunter T Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism Cell Res 2013 23 886 897 23670163
Grenier K McLelland GL Fon EA Parkin- and PINK1-dependent mitophagy in neurons: will the real pathway please stand up? Front Neurol 2013 4 100 23882257
Cai Q Zakaria HM Simone A Sheng ZH Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons Curr Biol 2012 22 545 552 22342752
Grenier K Kontogiannea M Fon EA Short mitochondrial ARF triggers parkin/PINK1-dependent mitophagy J Biol Chem 2014 289 29519 29530 25217637
Ashrafi G Schlehe JS LaVoie MJ Schwarz TL Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin J Cell Biol 2014 206 655 670 25154397
Scarffe LA Stevens DA Dawson VL Dawson TM Parkin and PINK1: much more than mitophagy Trends Neurosci 2014 37 315 324 24735649
McLelland GL Soubannier V Chen CX McBride HM Fon EA Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control EMBO J 2014 33 282 295 24446486
Soubannier V McLelland GL Zunino R Braschi E Rippstein P Fon EA McBride HM A vesicular transport pathway shuttles cargo from mitochondria to lysosomes Curr Biol 2012 22 135 141 22226745
Vincow ES Merrihew G Thomas RE Shulman NJ Beyer RP MacCoss MJ Pallanck LJ The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo Proc Natl Acad Sci USA 2013 110 6400 6405 23509287
Kuroda Y Mitsui T Kunishige M Shono M Akaike M Azuma H Matsumoto T Parkin enhances mitochondrial biogenesis in proliferating cells Hum Mol Genet 2006 15 883 895 16449237
Rothfuss O Fischer H Hasegawa T Maisel M Leitner P Miesel F Sharma M Bornemann A Berg D Gasser T Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair Hum Mol Genet 2009 18 3832 3850 19617636
Shin JH Ko HS Kang H Lee Y Lee YI Pletinkova O Troconso JC Dawson VL Dawson TM PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson’s disease Cell 2011 144 689 702 21376232
Lee Y Karuppagounder SS Shin JH Lee YI Ko HS Swing D Jiang H Kang SU Lee BD Kang HC Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss Nat Neurosci 2013 16 1392 1400 23974709
Ekholm-Reed S Goldberg MS Schlossmacher MG Reed SI Parkin-dependent degradation of the F-box protein Fbw7beta promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 Mol Cell Biol 2013 33 3627 3643 23858059
Muller-Rischart AK Pilsl A Beaudette P Patra M Hadian K Funke M Peis R Deinlein A Schweimer C Kuhn PH The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO Mol Cell 2013 49 908 921 23453807
Jiang HB Ren Y Zhao JH Feng J Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis Hum Mol Genet 2004 13 1745 1754 15198987
Ren Y Jiang H Yang F Nakaso K Feng J Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation J Biol Chem 2009 284 4009 4017 19074146
Hollville E Carroll RG Cullen SP Martin SJ Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy Mol Cell 2014 55 451 466 24999239
Johnson BN Berger AK Cortese GP LaVoie MJ The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax Proc Natl Acad Sci USA 2012 109 6283 6288 22460798
Berger AK Cortese GP Amodeo KD Weihofen A Letai A LaVoie MJ Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release Hum Mol Genet 2009 18 4317 4328 19679562
Zhang C Lee S Peng Y Bunker E Giaime E Shen J Zhou Z Liu X PINK1 triggers autocatalytic activation of parkin to specify cell fate decisions Curr Biol 2014 24 1854 1865 25088558
Zhang C Lin M Wu R Wang X Yang B Levine AJ Hu W Feng Z Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect Proc Natl Acad Sci USA 2011 108 16259 16264 21930938
Cesari R Martin ES Calin GA Pentimalli F Bichi R McAdams H Trapasso F Drusco A Shimizu M Masciullo V Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 Proc Natl Acad Sci U S A 2003 100 5956 5961 12719539
Fujiwara M Marusawa H Wang HQ Iwai A Ikeuchi K Imai Y Kataoka A Nukina N Takahashi R Chiba T Parkin as a tumor suppressor gene for hepatocellular carcinoma Oncogene 2008 27 6002 6011 18574468
Gong Y Zack TI Morris LG Lin K Hukkelhoven E Raheja R Tan IL Turcan S Veeriah S Meng S Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins Nat Genet 2014 46 588 594 24793136
Veeriah S Taylor BS Meng S Fang F Yilmaz E Vivanco I Janakiraman M Schultz N Hanrahan AJ Pao W Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies Nat Genet 2010 42 77 82 19946270
Mira MT Alcais A Nguyen VT Moraes MO Di Flumeri C Vu HT Mai CP Nguyen TH Nguyen NB Pham XK Susceptibility to leprosy is associated with PARK2 and PACRG Nature 2004 427 636 640 14737177
Manzanillo PS Ayres JS Watson RO Collins AC Souza G Rae CS Schneider DS Nakamura K Shiloh MU Cox JS The ubiquitin ligase parkin mediates resistance to intracellular pathogens Nature 2013 501 512 516 24005326
Bingol B Tea JS Phu L Reichelt M Bakalarski CE Song Q Foreman O Kirkpatrick DS Sheng M The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy Nature 2014 510 370 375 24896179
Cornelissen T Haddad D Wauters F Van Humbeeck C Mandemakers W Koentjoro B Sue C Gevaert K De Strooper B Verstreken P The deubiquitinase USP15 antagonizes parkin-mediated mitochondrial ubiquitination and mitophagy Hum Mol Genet 2014 23 5227 5242 24852371
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.