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Age‐associated decrease of senescence marker protein‐30/gluconolactonase in individual mouse liver cells: Immunohistochemistry and immunofluorescence

Geriatrics & gerontology international, v.15 no.6, 2015년, pp.804 - 810  

Ishigami, Akihito (Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Masutomi, Hirofumi (Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Handa, Setsuko (Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Maruyama, Naoki (Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan)

Abstract AI-Helper 아이콘AI-Helper

AimSenescence marker protein‐30 (SMP30)/gluconolactonase (GNL) is an age‐associated protein in that its presence decreases with aging. Here, we used immunohistochemical analysis to investigate the changes of SMP30/GNL in individual cells of the liver from progressively aged mice.MethodsM...

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참고문헌 (29)

  1. Fujita T , Uchida K , Maruyama N . Purification of senescence marker protein‐30 (SMP30) and its androgen‐independent decrease with age in the rat liver . Biochim Biophys Acta 1992 ; 1116 : 122 – 128 . 

  2. Mori T , Ishigami A , Seyama K et al . Senescence marker protein‐30 knockout mouse as a novel murine model of senile lung . Pathol Int 2004 ; 54 : 167 – 173 . 

  3. Ishigami A , Maruyama N . Significance of SMP30 in gerontology . Geriatr Gerontol Int 2007 ; 7 : 316 – 325 . 

  4. Maruyama N , Ishigami A , Kondo Y . Pathophysiological significance of senescence marker protein‐30 . Geriatr Gerontol Int 2010 ; 10 ( Suppl 1 ): S88 – S98 . 

  5. Fujita T , Mandel JL , Shirasawa T , Hino O , Shirai T , Maruyama N . Isolation of cDNA clone encoding human homologue of senescence marker protein‐30 (SMP30) and its location on the X chromosome . Biochim Biophys Acta 1995 ; 1263 : 249 – 252 . 

  6. Kagami Y , Kondo Y , Handa S , Maruyama N , Ishigami A . Senescence marker protein‐30 (SMP30)/ gluconolactonase (GNL) expression in the mouse ovary during gestation . Biol Pharm Bull 2013 ; 36 : 2005 – 2008 . 

  7. Ishigami A , Fujita T , Handa S et al . Senescence marker protein‐30 knockout mouse liver is highly susceptible to tumor necrosis factor‐α‐ and Fas‐mediated apoptosis . Am J Pathol 2002 ; 161 : 1273 – 1281 . 

  8. Ishigami A , Kondo Y , Nanba R et al . SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span . Biochem Biophys Res Commun 2004 ; 315 : 575 – 580 . 

  9. Hasegawa G , Yamasaki M , Kadono M et al . Senescence marker protein‐30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion . Endocrinology 2010 ; 151 : 529 – 536 . 

  10. Kondo Y , Inai Y , Sato Y et al . Senescence marker protein 30 functions as gluconolactonase in L‐ascorbic acid biosynthesis, and its knockout mice are prone to scurvy . Proc Natl Acad Sci U S A 2006 ; 103 : 5723 – 5728 . 

  11. Koike K , Kondo Y , Sekiya M et al . Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein‐30 knockout mice . Am J Physiol Lung Cell Mol Physiol 2010 ; 298 : L784 – L792 . 

  12. Ishikawa Y , Hashizume K , Kishimoto S et al . Effect of vitamin C depletion on UVR‐B induced cataract in SMP30/GNL knockout mice . Exp Eye Res 2012 ; 94 : 85 – 89 . 

  13. Sato Y , Arai KY , Nishiyama T et al . Ascorbic acid deficiency leads to epidermal atrophy and UVB‐induced skin pigmentation in SMP30/GNL knockout hairless mice . J Invest Dermatol 2012 ; 132 : 2112 – 2115 . 

  14. Arai KY , Sato Y , Kondo Y et al . Effects of vitamin C deficiency on the skin of the senescence marker protein‐30 (SMP30) knockout mouse . Biochem Biophys Res Commun 2009 ; 385 : 478 – 483 . 

  15. Kondo Y , Sasaki T , Sato Y et al . Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice . Biochem Biophys Res Commun 2008 ; 377 : 291 – 296 . 

  16. Sato Y , Kajiyama S , Amano A et al . Hydrogen‐rich pure water prevents superoxide formation in brain slices of vitamin C‐depleted SMP30/GNL knockout mice . Biochem Biophys Res Commun 2008 ; 375 : 346 – 350 . 

  17. Inai Y , Ohta Y , Nishikimi M . The whole structure of the human nonfunctional L‐gulono‐γ‐lactone oxidase gene – the gene responsible for scurvy – and the evolution of repetitive sequences thereon . J Nutr Sci Vitaminol 2003 ; 49 : 315 – 319 . 

  18. Iwama M , Amano A , Shimokado K , Maruyama N , Ishigami A . Ascorbic acid levels in various tissues, plasma and urine of mice during aging . J Nutr Sci Vitaminol 2012 ; 58 : 169 – 174 . 

  19. Ishigami A , Goto S . Inactivation kinetics of horseradish peroxidase microinjected into hepatocytes from mice of various ages . Mech Ageing Dev 1988 ; 46 : 125 – 133 . 

  20. Ishigami A , Goto S . Age‐related change in the degradation rate of ovalbumin microinjected into mouse liver parenchymal cells . Arch Biochem Biophys 1990 ; 277 : 189 – 195 . 

  21. Prentki M , Crettaz M , Jeanrenaud B . A possible complementary role of actin microfilaments and microtubules in triacylglycerol secretion by isolated rat hepatocytes . Biochim Biophys Acta 1980 ; 627 : 262 – 269 . 

  22. Prochniewicz‐Nakayama E , Yanagida T , Oosawa F . Studies on conformation of F‐actin in muscle fibers in the relaxed state, rigor, and during contraction using fluorescent phalloidin . J Cell Biol 1983 ; 97 : 1663 – 1667 . 

  23. Pinkert CA , Ornitz DM , Brinster RL , Palmiter RD . An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver‐specific expression in transgenic mice . Genes Dev 1987 ; 1 : 268 – 276 . 

  24. Fujita T , Shirasawa T , Maruyama N . Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein‐30 (SMP30) . Biochim Biophys Acta 1996 ; 1308 : 49 – 57 . 

  25. Supakar PC , Fujita T , Maruyama N . Identification of novel sequence‐specific nuclear factors interacting with mouse senescence marker protein‐30 gene promoter . Biochem Biophys Res Commun 2000 ; 272 : 436 – 440 . 

  26. Nejak‐Bowen KN , Zeng G , Tan X , Cieply B , Monga SP . β‐catenin regulates vitamin C biosynthesis and cell survival in murine liver . J Biol Chem 2009 ; 284 : 28115 – 28127 . 

  27. Logan CY , Nusse R . The Wnt signaling pathway in development and disease . Annu Rev Cell Dev Biol 2004 ; 20 : 781 – 810 . 

  28. Ishigami A , Handa S , Maruyama N , Supakar PC . Nuclear localization of senescence marker protein‐30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase . Biosci Biotechnol Biochem 2003 ; 67 : 158 – 160 . 

  29. Aizawa S , Senda M , Harada A et al . Structural basis of the gamma‐lactone‐ring formation in ascorbic acid biosynthesis by the senescence marker protein‐30/gluconolactonase . PLoS ONE 2013 ; 8 : e53706 . 

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