[논문]Nocebo in Alzheimer's disease; meta-analysis of placebo-controlled clinical trials

Zis, P.; Mitsikostas, D.D.

doi:10.1016/j.jns.2015.05.029

Nocebo in Alzheimer's disease; meta-analysis of placebo-controlled clinical trials

Journal of the neurological sciences, v.355 no.1/2, 2015년, pp.94 - 100

Zis, P. , Mitsikostas, D.D.

Abstract ▼ AI-Helper

Background and purpose: Nocebo is very prevalent among neurological diseases resulting in low adherence and treatment outcome. We sought to examine the AEs following placebo administration in Randomized Controlled Studies (RCTs) for Alzheimer's Disease (AD). Methods: After a systematic Medline search for RCTs for AD pharmacological treatments, we assessed the number of placebo-treated patients reporting at least one AE and the number of discontinuations because of placebo intolerance and searched for factors correlating to nocebo's extent. Results: Data were extracted from 20 RCTs fulfilling our search criteria. Of 3049 placebo-treated patients, 57.8% (95% CI: 50.1%-66.7%) reported at least one AE and 6.6% (95% CI: 5.3%-8.4%) discontinued placebo treatment because of AEs. All patients participating in these RCTs reported similar AEs independently of the study arm they belonged. Nocebo AE rate and dropout rate were positively related to study population size. The rates of AEs and dropouts because of AEs were parallel between placebo and active arms of RCTs (r=0.812, p<0.001 and r=0.787, p<0.001, respectively). Effectiveness rates correlated significantly to AEs rate and dropout rate because of AEs in placebo treated patients (r=0.787, p<0.001 and r=0.812, p<0.001, respectively). Conclusion: In RCTs for AD one out of fifteen patients treated with placebo dropped out because of AEs and three out of five experienced AEs indicating that adherence and effectiveness may be adversely affected with additional implications for clinical practice. The principal implications of this paper are that nocebo deserves much.

주제어

참고문헌 (28)

Eur. J. Neurol. Mitsikostas 19 5 672 2012 10.1111/j.1468-1331.2011.03528.x Nocebo in fibromyalgia: meta-analysis of placebo-controlled clinical trials and implications for practice

상세보기
Psychiatry Res. Mitsikostas 215 1 82 2014 10.1016/j.psychres.2013.10.019 Nocebo in clinical trials for depression: a meta-analysis

상세보기
Neuron Enck 59 195 2008 10.1016/j.neuron.2008.06.030 New insights into the placebo and nocebo responses

상세보기
JAMA Barsky 287 5 622 2002 10.1001/jama.287.5.622 Nonspecific medication side effects and the nocebo phenomenon

상세보기
Neuroscience Benedetti 147 260 2007 10.1016/j.neuroscience.2007.02.020 When words are painful: unraveling the mechanisms of the nocebo effect

상세보기
Nat. Med. Tracey 16 11 1277 2010 10.1038/nm.2229 Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans

상세보기
Pain Physician Manchikanti 14 2 E157 2011 Placebo and nocebo in interventional pain management: a friend or a foe-or simply foes?
Neurogastroenterol. Motil. Elsenbruch 24 10 2012 10.1111/j.1365-2982.2012.01950.x How positive and negative expectations shape the experience of visceral pain: an experimental pilot study in healthy women

상세보기
Mult. Scler. Papadopoulos 16 7 816 2010 10.1177/1352458510370793 Nocebo effects in multiple sclerosis trials: a meta-analysis

상세보기
Cephalalgia Mitsikostas 31 5 550 2011 10.1177/0333102410391485 Nocebo is the enemy, not placebo. A meta-analysis of reported side effects after placebo treatment in headaches

상세보기
Curr. Neurol. Neurosci. Rep. Mitsikostas 12 2 132 2012 10.1007/s11910-011-0245-4 Nocebo in headaches: implications for clinical practice and trial design

상세보기
J. Neurol. Papadopoulos 259 3 436 2012 10.1007/s00415-011-6197-4 A meta-analytic approach to estimating nocebo effects in neuropathic pain trials

상세보기
Clin. J. Pain Hauser 28 5 437 2012 10.1097/AJP.0b013e3182321ad8 Adverse events attributable to nocebo in randomized controlled drug trials in fibromyalgia syndrome and painful diabetic peripheral neuropathy: systematic review

상세보기
Eur. J. Neurol. Stathis 20 3 527 2013 10.1111/ene.12014 Nocebo as a potential confounding factor in clinical trials for Parkinson's disease treatment: a meta-analysis

상세보기
J. Clin. Psychiatry Rutherford 75 10 1040 2014 10.4088/JCP.13m08797 The role of patient expectancy in placebo and nocebo effects in antidepressant trials. J Clin Psychiatry. 2014 Jun 10

상세보기
Ann. Intern. Med. Moher 151 264 2009 10.7326/0003-4819-151-4-200908180-00135 PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

상세보기
Control. Clin. Trials Jadad 17 1 1996 10.1016/0197-2456(95)00134-4 Assessing the quality of reports of randomized clinical trials: is blinding necessary?

상세보기
Phys. Ther. Olivo 88 156 2008 10.2522/ptj.20070147 Scales to assess the quality of randomized controlled trials: a systematic review

상세보기
J. Stat. Softw. Viechtbauer 36 1 2010 10.18637/jss.v036.i03 Conducting meta-analyses in R with the metafor package
Stat. Med. Higgins 21 1539 2002 10.1002/sim.1186 Quantifying heterogeneity in a meta-analysis

상세보기
Biometrics Cochran 10 100 1954 10.2307/3001666 The combination of estimates from different experiments

상세보기
J. Eval. Clin. Pract. Ioannidis 14 951 2008 10.1111/j.1365-2753.2008.00986.x Interpretation of tests of heterogeneity and bias in meta-analysis

상세보기
BMJ Egger 315 629 1997 10.1136/bmj.315.7109.629 Bias in meta-analysis detected by a simple, graphical test

상세보기
Health Technol. Assess. Sutton 2 81 1998 10.3310/hta2190 Systematic reviews of trials and other studies: meta-regression

상세보기
Int. Psychogeriatr. Amanzio 24 5 698 2012 10.1017/S1041610211002420 A systematic review of adverse events in the placebo arm of donepezil trials: the role of cognitive impairment

상세보기
Pain Amanzio 146 3 261 2009 10.1016/j.pain.2009.07.010 A systematic review of adverse events in placebo groups of anti-migraine clinical trials

상세보기
Pain Petersen 155 8 1426 2014 10.1016/j.pain.2014.04.016 The magnitude of nocebo effects in pain: a meta-analysis

상세보기
Psychosom. Med. Colloca 73 7 598 2011 10.1097/PSY.0b013e3182294a50 The nocebo effect and its relevance for clinical practice

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Nocebo in Alzheimer's disease; meta-analysis of placebo-controlled clinical trials

Abstract ▼ AI-Helper

주제어

참고문헌 (28)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트