[논문]The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells

Park, Gwang Hun; Park, Jae Ho; Eo, Hyun Ji; Song, Hun Min; Woo, So Hee; Kim, Mi Kyoung; Lee, Jin Wook; Lee, Man Hyo; Lee, Jeong Rak; Koo, Jin Suk; Jeong, Jin Boo

doi:10.1186/1472-6882-14-487

The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells 원문보기

Bmc complementary and alternative medicine, v.14, 2014년, pp.487 -

Park, Gwang Hun (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Park, Jae Ho (Department of Medicinal Plant Science, Jungwon University, Goesan, 367805 Korea) , Eo, Hyun Ji (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Song, Hun Min (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Woo, So Hee (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Kim, Mi Kyoung (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Lee, Jin Wook (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Lee, Man Hyo (Gyeongbuk Institute for Bio-industry, Andong, 760380 Korea) , Lee, Jeong Rak (Gyeongbuk Institute for Bio-industry, Andong, 760380 Korea) , Koo, Jin Suk (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea) , Jeong, Jin Boo (Department of Bioresource Sciences, Andong National University, Andong, 760749 Korea)

Abstract ▼ AI-Helper

BackgroundRecently, Abeliophyllum distichum Nakai (A. distichum) has been reported to exert the inhibitory effect on angiotensin converting enzyme. However, no specific pharmacological effects from A. distichum have been described. We performed in vitro study to evaluate anti-cancer properties of A. distichum and then elucidate the potential mechanisms.MethodsCell viability was measured by MTT assay. ATF3 expression level was evaluated by Western blot or RT-PCR and ATF3 transcriptional activity was determined using a dual-luciferase assay kit after the transfection of ATF3 promoter constructs. In addition, ATF3-dependent apoptosis was evaluated by Western blot after ATF3 knockdown using ATF3 siRNA.ResultsExposure of ethyl acetate fraction from the parts of A. distichum including flower, leaf and branch to human colorectal cancer cells, breast cancer cells and hepatocellular carcinoma reduced the cell viability. The branch extracts from A. distichum (EAFAD-B) increased the expression of activating transcription factor 3 (ATF3) and promoter activity, indicating transcriptional activation of ATF3 gene by EAFAD-B. In addition, our data showed that EAFAD-B-responsible sites might be between -147 and -85 region of the ATF3 promoter. EAFAD-B-induced ATF3 promoter activity was significantly decreased when the CREB site was deleted. However, the deletion of Ftz sites did not affect ATF3 promoter activity by EAFAD-B. We also observed that inhibition of p38MAPK and GSK3β attenuated EAFAD-B-mediated ATF3 promoter activation. Also, EAFAD-B contributes at least in part to increase of ATF3 accumulation.ConclusionThese findings suggest that the anti-cancer activity of EAFAD-B may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression.

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The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells 원문보기

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The induction of activating transcription factor 3 (ATF3) contributes to anti-cancer activity of Abeliophyllum distichum Nakai in human colorectal cancer cells 원문보기

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