$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends 원문보기

PLoS genetics, v.8 no.6, 2012년, pp.e1002747 -   

Pfeiffer, Verena (Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fé) ,  Lingner, Joachim (dé)

Abstract AI-Helper 아이콘AI-Helper

The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telomeres. To study the mechanism of telomere length co...

참고문헌 (44)

  1. 1 Jain D Cooper JP 2010 Telomeric strategies: means to an end. Annual review of genetics 44 243 269 

  2. 2 de Lange T 2009 How telomeres solve the end-protection problem. Science 326 948 952 19965504 

  3. 3 Bodnar AG Ouellette M Frolkis M Holt SE Chiu C-P 1998 Extension of life-span by introduction of telomerase into normal human cells. Science 279 349 352 9454332 

  4. 4 Teixeira MT Arneric M Sperisen P Lingner J 2004 Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117 323 335 15109493 

  5. 5 Marcand S Brevet V Gilson E 1999 Progressive cis-inhibition of telomerase upon telomere elongation. EMBO J 18 3509 3519 10369690 

  6. 6 Marcand S Wotton D Gilson E Shore D 1997 Rap1p and telomere length regulation in yeast. Ciba Foundation symposium 211 76 93; discussion 93–103 9524752 

  7. 7 Wellinger RJ Ethier K Labrecque P Zakian VA 1996 Evidence for a new step in telomere maintenance. Cell 85 423 433 8616897 

  8. 8 Lundblad V Szostak JW 1989 A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57 633 643 2655926 

  9. 9 Chang M Arneric M Lingner J 2007 Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes Dev 21 2485 2494 17908934 

  10. 10 Arneric M Lingner J 2007 Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast. EMBO Rep 8 1080 1085 17917674 

  11. 11 Sabourin M Tuzon CT Zakian VA 2007 Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol Cell 27 550 561 17656141 

  12. 12 Hector RE Shtofman RL Ray A Chen BR Nyun T 2007 Tel1p preferentially associates with short telomeres to stimulate their elongation. Molecular cell 27 851 858 17803948 

  13. 13 Bianchi A Shore D 2007 Increased association of telomerase with short telomeres in yeast. Genes & development 21 1726 1730 17639079 

  14. 14 Larrivee M LeBel C Wellinger RJ 2004 The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev 18 1391 1396 15198981 

  15. 15 Bonetti D Martina M Clerici M Lucchini G Longhese MP 2009 Multiple pathways regulate 3′ overhang generation at S. cerevisiae telomeres. Molecular cell 35 70 81 19595717 

  16. 16 Gravel S Larrivée M Labrecque P Wellinger RJ 1998 Yeast Ku as a regulator of chromosomal DNA end structure. Science 280 741 744 9563951 

  17. 17 Polotnianka RM Li J Lustig AJ 1998 The yeast ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr Biol 8 831 834 9663392 

  18. 18 Maringele L Lydall D 2002 EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes & Dev 16 1919 1933 12154123 

  19. 19 Bertuch AA Lundblad V 2004 EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. Genetics 166 1651 1659 15126387 

  20. 20 Garvik B Carson M Hartwell L 1995 Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 15 6128 6138 7565765 

  21. 21 Nugent CI Hughes TR Lue NF Lundblad V 1996 Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274 249 252 8824190 

  22. 22 Booth C Griffith E Brady G Lydall D 2001 Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction. Nucleic acids research 29 4414 4422 11691929 

  23. 23 Feuerhahn S Iglesias N Panza A Porro A Lingner J 2010 TERRA biogenesis, turnover and implications for function. FEBS Lett 

  24. 24 Redon S Reichenbach P Lingner J 2010 The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res 

  25. 25 Schoeftner S Blasco MA 2008 Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 10 228 236 18157120 

  26. 26 Flynn RL Centore RC O'Sullivan RJ Rai R Tse A 2011 TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature 471 532 536 21399625 

  27. 27 Azzalin CM Reichenbach P Khoriauli L Giulotto E Lingner J 2007 Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318 798 801 17916692 

  28. 28 Chawla R Redon S Raftopoulou C Wischnewski H Gagos S 2011 Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. The EMBO journal 30 4047 4058 21829167 

  29. 29 Yehezkel S Segev Y Viegas-Pequignot E Skorecki K Selig S 2008 Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum Mol Genet 17 2776 2789 18558631 

  30. 30 Luke B Panza A Redon S Iglesias N Li Z 2008 The Rat1p 5′ to 3′ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell 32 465 477 19026778 

  31. 31 Sandell LL Gottschling DE Zakian VA 1994 Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proc Natl Acad Sci U S A 91 12061 12065 7991584 

  32. 32 Louis EJ 1995 The chromosome ends of Saccharomyces cerevisiae . Yeast 11 1553 1573 8720065 

  33. 33 Iglesias N Redon S Pfeiffer V Dees M Lingner J 2011 Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO reports 12 587 593 21525956 

  34. 34 Yen K Gitsham P Wishart J Oliver SG Zhang N 2003 An improved tetO promoter replacement system for regulating the expression of yeast genes. Yeast 20 1255 1262 14618563 

  35. 35 Forstemann K Hoss M Lingner J 2000 Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres. Nucleic Acids Res 28 2690 2694 10908324 

  36. 36 Shampay J Blackburn EH 1988 Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 85 534 538 3277178 

  37. 37 Craven RJ Petes TD 1999 Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae . Genetics 152 1531 1541 10430581 

  38. 38 Fisher TS Taggart AK Zakian VA 2004 Cell cycle-dependent regulation of yeast telomerase by Ku. Nat Struct Mol Biol 11 1198 1205 15531893 

  39. 39 Stellwagen AE Haimberger ZW Veatch JR Gottschling DE 2003 Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes & Dev 17 2384 2395 12975323 

  40. 40 Pfingsten JS Goodrich KJ Taabazuing C Ouenzar F Chartrand P 2012 Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell 148 922 932 22365814 

  41. 41 Ng LJ Cropley JE Pickett HA Reddel RR Suter CM 2009 Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic acids research 37 1152 1159 19129228 

  42. 42 Ito H Fukuda Y Murata K Kimura A 1983 Transformation of intact yeast cells treated with alkali cations. Journal of bacteriology 153 163 168 6336730 

  43. 43 Longtine MS McKenzie A 3rd Demarini DJ Shah NG Wach A 1998 Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae . Yeast 14 953 961 9717241 

  44. 44 Guarente L Mason T 1983 Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell 32 1279 1286 6301690 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로