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NTIS 바로가기PloS one, v.8 no.8, 2013년, pp.e69404 -
Namjou, Bahram (Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America) , Kim-Howard, Xana (Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America) , Sun, Celi (Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America) , Adler, Adam (Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America) , Chung, Sharon A. (Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America) , Kaufman, Kenneth M. (Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America) , Kelly, Jennifer A. (Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America) , Glenn, Stuart B. (Arthritis and Clinical I) , Guthridge, Joel M. , Scofield, Robert H. , Kimberly, Robert P. , Brown, Elizabeth E. , Alarcón, Graciela S. , Edberg, Jeffrey C. , Kim, Jae-Hoon , Choi, Jiyoung , Ramsey-Goldman, Rosalind , Petri, Michelle A. , Reveille, John D. , Vilá, Luis M. , Boackle, Susan A. , Freedman, Barry I. , Tsao, Betty P. , Langefeld, Carl D. , Vyse, Timothy J. , Jacob, Chaim O. , Pons-Estel, Bernardo , Niewold, Timothy B. , Moser Sivils, Kathy L. , Merrill, Joan T. , Anaya, Juan-Manuel , Gilkeson, Gary S. , Gaffney, Patrick M. , Bae, Sang-Cheol , Alarcón-Riquelme, Marta E. , Harley, John B. , Criswell, Lindsey A. , James, Judith A. , Nath, Swapan K.
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). Missense rs2476601 is associated with SLE in individuals with European ancestry. Since the rs2476601 risk...
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