[논문]Deltamethrin is toxic to the fish (crucian carp, Carassius carassius) heart

Haverinen, J.; Vornanen, M.

doi:10.1016/j.pestbp.2015.10.014

Deltamethrin is toxic to the fish (crucian carp, Carassius carassius) heart

Pesticide biochemistry and physiology, v.129, 2016년, pp.36 - 42

Haverinen, J. , Vornanen, M.

Abstract ▼ AI-Helper

Pyrethroids are extensively used for the control of insect pests and disease vectors. Pyrethroids are regarded safe due to their selective toxicity: they are effective against insects but relatively harmless to mammals and birds. Unfortunately, pyrethroids are very toxic to fishes. The high toxicity of pyrethroids to fishes is only partly explained by slow metabolic elimination of pyrethroids, suggesting that some molecular targets in vital organs of the fish body are sensitive to pyrethroids. To this end we tested the effect of deltamethrin (DM) on fish (crucian carp, Carassius carassius) heart function in vitro. In sinoatrial preparations of the crucian carp heart DM (10μM) caused irregularities in rate and rhythm of atrial beating and strong reductions in force of atrial contraction, thus indicating that DM is arrhythmogenic to the fish heart. Consistent with this, DM (10.0μM) induced irregularities in electrical activity (surface electrocardiogram) of spontaneous beating hearts in vitro. In isolated ventricular myocytes, DM (0.1-30.0μM) modified Na+ current by slowing channel closing and shifting reversal potential and steady-state activation of the current to more negative voltages. Maximally about 48% of the cardiac Na+ channels were affected by DM with a half-maximal effect occurring at the concentration of 1.3μM. These findings indicate that DM can be cardiotoxic to the crucian carp and that these effects could be due to DM related changes in Na+ channel function. These findings indicate that in addition to their neurotoxicity effects pyrethroid could also be cardiotoxic to fishes.

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참고문헌 (30)

Rev. Environ. Contam. Toxicol. Bradbury 108 133 1989 10.1007/978-1-4613-8850-0_4 Comparative toxicology of the pyrethroid insecticides

상세보기
Annu. Rev. Pharmacol. Toxicol. Casida 23 413 1983 10.1146/annurev.pa.23.040183.002213 Mechanisms of selective action of pyrethroid insecticides

상세보기
Hum. Exp. Toxicol. Narahashi 26 361 2007 10.1177/0960327106078408 Differential actions of insecticides on target sites: basis for selective toxicity

상세보기
Toxicol. Appl. Pharmacol. Edwards 84 512 1986 10.1016/0041-008X(86)90256-5 Comparative toxicity of cis-cypermethrin in rainbow trout, frog, mouse and quail

상세보기
Bull. Environ. Contam. Toxicol. Paul 76 614 2006 10.1007/s00128-006-0964-4 Toxicity of three mosquito insecticides to craysfish

상세보기
Palmquist 251 2012 Insecticides - Advances in Integrated Pest Management Pyrethroid Insecticides: Use, Environmantal Fate, and Ecotoxicology
Environ. Pollut. Weston 159 3051 2011 10.1016/j.envpol.2011.04.008 Pyrethroid insecticides in urban salmon streams of the Pacific Northwest

상세보기
Toxicol. Appl. Pharmacol. Glickman 66 153 1982 10.1016/0041-008X(82)90280-0 Differential toxicity of trans-permethrin in rainbow trout and mice. II. Role of biotransformation

상세보기
Aquat. Toxicol. Wheelock 74 172 2005 10.1016/j.aquatox.2005.05.009 Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos

상세보기
Toxicol. Appl. Pharmacol. Glickman 66 162 1982 10.1016/0041-008X(82)90281-2 Differential toxicity of trans-permethrin in rainbow trout. I. Role of target organ sensitivity

상세보기
Neurotoxicology Narahashi 6 3 1985 Nerve membrane ion channels as the primary target of pyrethroids
Mol. Biol. Evol. Widmark 28 859 2011 10.1093/molbev/msq257 Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes

상세보기
Neurotoxicol. Teratol. Wolansky 30 55 2008 10.1016/j.ntt.2007.10.005 Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review

상세보기
Top. Curr. Chem. Clark 314 49 2012 10.1007/128_2011_268 Advances in the mode of action of pyrtehroids
J. Mol. Cell. Cardiol. Moreno 52 608 2012 10.1016/j.yjmcc.2011.12.003 Pathophysiology of the cardiac late Na current and its potential as a drug target

상세보기
Pestic. Biochem. Physiol. Bradbury 27 275 1987 10.1016/0048-3575(87)90057-5 Physiological response of rainbow trout (Salmo gairdneri) to acute fenvalerate intoxication

상세보기
Ecotoxicol. Environ. Saf. Viran 55 82 2003 10.1016/S0147-6513(02)00096-9 Investigation of acute toxicity of deltamethrin on guppies (Poecilia reticulata)

상세보기
Am. J. Phys. Vornanen 272 R1432 1997 Sarcolemmal Ca influx through L-type Ca channels in ventricular myocytes of a teleost fish
J. Exp. Biol. Haverinen 207 2823 2004 10.1242/jeb.01103 Temperature acclimation modifies Na+ current in fish cardiac myocytes

상세보기
J. Pharmacol. Exp. Ther. Tatebayashi 270 595 1994 Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels

상세보기
Bull. World Health Organ. Narahashi 44 337 1971 Mode of action of pyrethroids

상세보기
J. Agric. Food Chem. Gammon 59 2773 2011 10.1021/jf103901k Pyrethroid mode(s) of action in the context of food quality protection act (FQPA) regulation

상세보기
Arch. Med. Res. de la Cerda 33 448 2002 10.1016/S0188-4409(02)00389-2 Modulation of cardiac action potential and underlying ionic currents by the pyrethroid insecticide deltamethrin

상세보기
J. Cardiovasc. Pharmacol. Spencer 298 1067 2001 Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts
Physiol. Rev. Fozzard 76 887 1996 10.1152/physrev.1996.76.3.887 Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

상세보기
Mar. Drugs Vornanen 9 2409 2011 10.3390/md9112409 Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current

상세보기
Comp. Biochem. Physiol. C: Toxicol. Pharmacol. Haverinen 159 1 2014 Effects of deltamethrin on excitability and contractility of the rainbow trout (Oncorhynchus mykiss) heart
Acta Physiol. Haverinen 191 197 2007 10.1111/j.1748-1716.2007.01734.x Fish cardiac sodium channels are tetrodotoxin sensitive

상세보기
Toxicol. Appl. Pharmacol. Shafer 196 303 2004 10.1016/j.taap.2003.12.013 Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity

상세보기
Invertebr. Neurosci. Clark 7 3 2007 10.1007/s10158-006-0038-7 Pyrethroid action on calcium channels: neurotoxicological implications

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Deltamethrin is toxic to the fish (crucian carp, Carassius carassius) heart

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