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Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions 원문보기

Scientific reports, v.6, 2016년, pp.32258 -   

Bae, Song Yi (College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea) ,  Park, Hyen Joo (College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea) ,  Hong, Ji-Young (College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea) ,  Lee, Hye-Jung (College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea) ,  Lee, Sang Kook (College of Pharmacy, Natural Products Research Institute, Seoul National University , Seoul 151-742, Korea)

Abstract AI-Helper 아이콘AI-Helper

The failure of targeted therapy due to the resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is considered a major problem in the treatment of non-small cell lung cancer (NSCLC) patients. SerpinB2, a component of the urokinase plasminogen activ...

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