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Post-Stroke Fatigue May Be Associated with the Promoter Region of a Monoamine Oxidase A Gene Polymorphism

Cerebrovascular diseases, v.43 no.1/2, 2017년, pp.54 - 58  

Choi-Kwon, Smi ,  Ko, Mihye ,  Jun, Sang-Eun ,  Kim, Juhan ,  Cho, Kyung-Hee ,  Nah, Hyun-Wook ,  Song, Hasup ,  Kim, Jong S.

Abstract ▼ AI-Helper 아이콘AI-Helper

Background: Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. Methods: A total of 373 patients, who experienced ischemic str...

주제어

#Gene   #Fatigue   #Depression   #Stroke  

참고문헌 (24)

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  2. 2 Vincent-Onabajo G, Adamu A: Impact of poststroke fatigue on health-related quality of life of Nigerian stroke survivors. J Stroke 2014;16:195-201. 

  3. 3 Choi-Kwon S, Han SW, Kwon SU, Kim JS: Poststroke fatigue: characteristics and related factors. Cerebrovasc Dis 2005;19:84-90. 

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  7. 7 Choi-Kwon S, Han K, Choi S, Suh M, Kim YJ, Song H, Cho KH, Nah HW, Kwon SU, Kang DW, Kim JS: Poststroke depression and emotional incontinence: factors related to acute and subacute stages. Neurology 2012;78:1130-1137. 

  8. 8 Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD: The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989;46:1121-1123. 

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  10. 10 Choi-Kwon S, Han K, Cho KH, Choi S, Suh M, Nah HW, Kim JS: Factors associated with post-stroke anger proneness in ischaemic stroke patients. Eur J Neurol 2013;20:1305-1310. 

  11. 11 Nielsen FC, Rehfeld JF: Measurement of gut hormone gene expression: mRNA and peptides. Baillieres Clin Endocrinol Metab 1994;8:25-49. 

  12. 12 Yoon HK, Yang JC, Lee HJ, Kim YK: The association between serotonin-related gene polymorphisms and panic disorder. J Anxiety Disord 2008;22:1529-1534. 

  13. 13 Shiroiwa K, Hishimoto A, Mouri K, Fukutake M, Supriyanto I, Nishiguchi N, Shirakawa O: Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population. Neurosci Lett 2010;472:194-198. 

  14. 14 Choi-Kwon S, Kim JS: Poststroke fatigue: an emerging, critical issue in stroke medicine. Int J Stroke 2011;6:328-336. 

  15. 15 Wu S, Mead G, Macleod M, Chalder T: Model of understanding fatigue after stroke. Stroke 2015;46:893-898. 

  16. 16 Smith AK, Dimulescu I, Falkenberg VR, Narasimhan S, Heim C, Vernon SD, Rajeevan MS: Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology 2008;33:188-197. 

  17. 17 Glader EL, Stegmayr B, Asplund K: Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden. Stroke 2002;33:1327-1333. 

  18. 18 Mead GE, Graham C, Dorman P, Bruins SK, Lewis SC, Dennis MS, Sandercock PA; UK Collaborators of IST: Fatigue after stroke: baseline predictors and influence on survival. Analysis of data from UK patients recruited in the international stroke trial. PLoS One 2011;6:e16988. 

  19. 19 Naess H, Lunde L, Brogger J, Waje-Andreassen U: Fatigue among stroke patients on long-term follow-up. The Bergen stroke study. J Neurol Sci 2012;312:138-141. 

  20. 20 Christensen D, Johnsen SP, Watt T, Harder I, Kirkevold M, Andersen G: Dimensions of post-stroke fatigue: a two-year follow-up study. Cerebrovasc Dis 2008;26:134-141. 

  21. 21 Choi-Kwon S, Choi J, Kwon SU, Kang DW, Kim JS: Fluoxetine is not effective in the treatment of post-stroke fatigue: a double-blind, placebo-controlled study. Cerebrovasc Dis 2007;23:103-108. 

  22. 22 Kim JS: Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms. J Stroke 2016;18:244-255. 

  23. 23 Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN: Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 2001;92:179-212. 

  24. 24 Dobryakova E, Genova HM, DeLuca J, Wylie GR: The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders. Front Neurol 2015;6:52. 

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