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[해외논문] Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways 원문보기

Scientific reports, v.7, 2017년, pp.43639 -   

Liao, Xin-Hua (Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou , Fujian 350122, China) ,  Zhang, Arina Li (Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou , Fujian 350122, China) ,  Zheng, Min (Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou , Fujian 350122, China) ,  Li, Mei-Qing (Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou , Fujian 350122, China) ,  Chen, Champ Peng (Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical) ,  Xu, Huijuan ,  Chu, Qing-Song ,  Yang, Dayun ,  Lu, Wenxian ,  Tsai, Ting-Fen ,  Liu, Hekun ,  Zhou, Xiao Zhen ,  Lu, Kun Ping

Abstract AI-Helper 아이콘AI-Helper

Hepatocellular carcinoma (HCC) is one of the most prevalent and malignant cancers with high inter- and intra-tumor heterogeneity. A central common signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1. Pin1 is prevalently o...

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