최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Journal of pharmaceutical sciences : a publication of the American Pharmaceutical Association, v.106 no.3, 2017년, pp.898 - 905
Trapa, Patrick E. , Beaumont, Kevin , Atkinson, Karen , Eng, Heather , King-Ahmad, Amanda , Scott, Dennis O. , Maurer, Tristan S. , Di, Li
초록이 없습니다.
Kwon 2001 Handbook of Essential Pharmacokinetics, Pharmacodynamics, and Drug Metabolism for Industrial Scientists
Expert Opin Drug Metab Toxicol Galetin 4 7 909 2008 10.1517/17425255.4.7.909 Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions
Drug Metab Dispos Gertz 38 7 1147 2010 10.1124/dmd.110.032649 Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data
Curr Drug Metab Gertz 9 8 785 2008 10.2174/138920008786049276 Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations
Drug Metab Dispos Matsuda 41 8 1514 2013 10.1124/dmd.113.051680 In vivo assessment of the impact of efflux transporter on oral drug absorption using portal vein-cannulated rats
Pharm Res Matsuda 32 2 604 2015 10.1007/s11095-014-1489-x Quantitative assessment of intestinal first-pass metabolism of oral drugs using portal-vein cannulated rats
Drug Metab Dispos Matsuda 40 12 2231 2012 10.1124/dmd.112.048223 Assessment of intestinal availability of various drugs in the oral absorption process using portal vein-cannulated rats
Biopharm Drug Dispos Holenarsipur 36 6 385 2015 10.1002/bdd.1950 Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models
Mol Pharm Babusis 10 2 459 2013 10.1021/mp3002045 Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340
Lab Animal Shen 37 1 41 2008 10.1038/laban0108-41 A portal vein cannulation technique for drug discovery in mice
Eur J Drug Metab Pharmacokinet Pan-Zhou 1 5 567 2015 10.1007/s13318-015-0267-4 Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2'-methylguanosine-5'-monophosphate, in the monkey and formulation optimization for human exposure
Biopharm Drug Dispos Reddy 32 5 261 2011 10.1002/bdd.756 Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible
Arch Biochem Biophys Uno 466 1 98 2007 10.1016/j.abb.2007.07.003 Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?
Biochim Biophys Acta Gene Struct Expr Komori 1171 2 141 1992 10.1016/0167-4781(92)90113-E Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450
Arch Toxicol Shimada 71 6 401 1997 10.1007/s002040050403 Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, Guinea pigs, dogs, monkeys, and humans
Drug Metab Dispos Williams 39 12 2305 2011 10.1124/dmd.111.041335 Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human
Expert Opin Drug Metab Toxicol Chu 9 3 237 2013 10.1517/17425255.2013.741589 Species differences in drug transporters and implications for translating preclinical findings to humans
Drug Metab Dispos Nishimuta 38 11 1967 2010 10.1124/dmd.110.034561 Prediction of the intestinal first-pass metabolism of CYP3A substrates in humans using cynomolgus monkeys
Expert Opin Drug Metab Toxicol Dokoumetzidis 3 4 491 2007 10.1517/17425255.3.4.491 Predictive models for oral drug absorption: from in silico methods to integrated dynamical models
Curr Drug Metab Yang 8 7 676 2007 10.2174/138920007782109733 Prediction of intestinal first-pass drug metabolism
J Control Release Benet 62 1-2 25 1999 10.1016/S0168-3659(99)00034-6 Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
Drug Metab Dispos Karlsson 41 12 2033 2013 10.1124/dmd.113.051664 Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and preclinical development
Drug Metab Pharmacokinet Nishimuta 26 6 592 2011 10.2133/dmpk.DMPK-11-RG-034 Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data
Drug Metab Pharmacokinet Furukawa 27 2 171 2012 10.2133/dmpk.DMPK-11-RG-088 Quantitative prediction of intestinal glucuronidation of drugs in rats using in vitro metabolic clearance data
Curr Drug Metab Beaumont 4 6 461 2003 10.2174/1389200033489253 Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist
Drug Metab Dispos Nishimuta 42 9 1522 2014 10.1124/dmd.114.057372 Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs
J Pharm Sci Di 100 11 4974 2011 10.1002/jps.22674 Development of a new permeability assay using low-efflux MDCKII cells
Eur J Pharm Sci Avdeef 28 1-2 43 2006 10.1016/j.ejps.2005.12.008 PAMPA-a drug absorption in vitro model. 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models
Adv Drug Deliv Rev Agoram 50 Suppl. 1 S41 2001 10.1016/S0169-409X(01)00179-X Predicting the impact of physiological and biochemical processes on oral drug bioavailability
Drug Metab Dispos Gertz 39 9 1633 2011 10.1124/dmd.111.039248 Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction
Int J Pharm Yu 140 1 111 1996 10.1016/0378-5173(96)04592-9 Compartmental transit and dispersion model analysis of small intestinal transit flow in humans
Food Chem Toxicol DeSesso 39 3 209 2001 10.1016/S0278-6915(00)00136-8 Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats
Int J Pharm Karlsson 71 1-2 55 1991 10.1016/0378-5173(91)90067-X A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial (Caco-2) cells grown in permeable filter chambers
Eur J Pharm Sci Fagerholm 3 5 247 1995 10.1016/0928-0987(95)00027-B Experimental estimation of the effective unstirred water layer thickness in the human jejunum, and its importance in oral drug absorption
Am Inst Chem Eng J Wilke 1 264 1955 10.1002/aic.690010222 Correlation of diffusion coefficients in dilute solutions
J Pharm Sci Johnson 101 2 681 2012 10.1002/jps.22778 Comparison of methods for predicting dissolution and the theoretical implications of particle-size-dependent solubility
Cell Tissue Res Buschmann 231 2 289 1983 10.1007/BF00222181 Morphometry of the small intestinal enterocytes of the fasted rat and the effects of colchicine
Molecules Hosokawa 13 2 412 2008 10.3390/molecules13020412 Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs
Drug Metab Dispos Sato 40 7 1389 2012 10.1124/dmd.112.045054 Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry
Life Sci Taketani 81 11 924 2007 10.1016/j.lfs.2007.07.026 Carboxylesterase in the liver and small intestine of experimental animals and human
Pharmacotherapy Laizure 33 2 210 2013 10.1002/phar.1194 The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
Curr Drug Metab Imai 11 9 793 2010 10.2174/138920010794328904 The role of intestinal carboxylesterase in the oral absorption of prodrugs
Drug Metab Dispos Imai 34 10 1734 2006 10.1124/dmd.106.009381 Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
J Pharm Sci Ohura 104 9 3076 2015 10.1002/jps.24467 Design of fexofenadine prodrugs based on tissue-specific esterase activity and their dissimilar recognition by P-glycoprotein
Drug Metab Dispos Imai 33 8 1185 2005 10.1124/dmd.105.004226 Identification of esterases expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption
Mol Cancer Ther Landowski 4 4 659 2005 10.1158/1535-7163.MCT-04-0290 Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs
Pharm Res Tantishaiyakul 19 7 1013 2002 10.1023/A:1016470523923 Characterization of mefenamic acid-guaiacol ester: stability and transport across Caco-2 cell monolayers
Drug Metab Dispos Fujiyama 38 12 2210 2010 10.1124/dmd.110.034249 Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.