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Spatholobus suberectus Dunn. constituents inhibit sortase A and Staphylococcus aureus cell clumping to fibrinogen

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.40 no.4, 2017년, pp.518 - 523  

Cho, Hyunjoo ,  Chung, Beomkoo ,  Kim, Chang-Kwon ,  Oh, Dong-Chan ,  Oh, Ki-Bong ,  Shin, Jongheon

Abstract AI-Helper 아이콘AI-Helper

Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In Staphylococcus aureus (S. aureus), deletion of sortase isoform results in a significant reduction in virulence and infection potential. Twenty f...

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