[논문]Risk Factors for Aseptic Meningitis in Herpes Zoster Patients

Kim, Sang-Hoon; Choi, Seong-Min; Kim, Byeong C.; Choi, Kang-Ho; Nam, Tai-Seung; Kim, Joon-Tae; Lee, Seung-Han; Park, Man-Seok; Kim, Seong J.

doi:10.5021/ad.2017.29.3.283

Risk Factors for Aseptic Meningitis in Herpes Zoster Patients 원문보기

Annals of dermatology, v.29 no.3, 2017년, pp.283 - 287

Kim, Sang-Hoon (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Choi, Seong-Min (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Kim, Byeong C. (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Choi, Kang-Ho (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Nam, Tai-Seung (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Kim, Joon-Tae (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Lee, Seung-Han (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Park, Man-Seok (Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.) , Kim, Seong J. (Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.)

Abstract ▼ AI-Helper

BackgroundHerpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection. HZ-associated aseptic meningitis, a rare complication of HZ, can require hospitalization and a long treatment period.ObjectiveA retrospective study was performed to identify potential factors associated with HZ-associated aseptic meningitis development.MethodsWe included all outpatients and patients admitted in the neurology and dermatology departments of a single tertiary center, who were diagnosed with HZ for two years. Among 818 patients, 578 patients were eligible for analysis.ResultsThe demographics and potential risk factors were compared between the uncomplicated HZ group (n=554) and aseptic meningitis group (n=24). Among the potential factors, the dermatological distribution of skin rash and gender showed statistically significantly different between the two groups. Patients with craniocervical distribution of HZ accounted for 87.5% (n=21) of the aseptic meningitis group and 54.3% (n=301) of the uncomplicated HZ group (p=0.043). The aseptic meningitis group had more men (66.7%, n=16) than the uncomplicated HZ group (42.8%, n=237, p=0.033). Patients with craniocervical distribution had an odds ratio (OR) of 5.884 (p=0.001) for developing aseptic meningitis when compared with the other dermatome involvements. Additional logistic regression analysis resulted in a fading between gender difference (p=0.050) and craniocervical involvement having an OR of 5.667 for aseptic meningitis (p=0.006).ConclusionIn HZ patients, skin rash with craniocervical distribution and male gender were associated with a higher risk of aseptic meningitis.

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참고문헌 (18)

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Risk Factors for Aseptic Meningitis in Herpes Zoster Patients 원문보기

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Risk Factors for Aseptic Meningitis in Herpes Zoster Patients 원문보기

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