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Myostatin-like proteins regulate synaptic function and neuronal morphology 원문보기

Development, v.144 no.13, 2017년, pp.2445 - 2455  

Augustin, Hrvoje (Institute of Healthy Ageing, and GEE, University College London , Darwin Building, Gower Street , London WC1E 6BT , UK) ,  McGourty, Kieran (Institute of Structural and Molecular Biology, University College London , Darwin Building Gower Street, London WC1E 6BT , UK) ,  Steinert, Joern R. (MRC Toxicology Unit, Hodgkin Building , University of Leicester , Lancaster Road, Leicester LE1 9HN , UK) ,  Cochemé, Helena M. (Institute of Healthy Ageing, and GEE, University College London , Darwin Building, Gower Street , London WC1E 6BT , UK) ,  Adcott, Jennifer (Institute of Healthy Ageing, and GEE, University College London , Darwin Building, Gower Street , London WC1E 6BT , UK) ,  Cabecinha, Melissa (Institute of Healthy Ageing, and GEE, University College London , Darwin Building, Gower Street , London WC1E 6BT , UK) ,  Vincent, Alec (Institute of Healthy Ageing, and GEE, University College London , Darwin Building, Gower Street , London WC1E 6BT , UK) ,  Halff, Els F. ,  Kittler, Josef T. ,  Boucrot, Emmanuel ,  Partridge, Linda

Abstract AI-Helper 아이콘AI-Helper

Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of myostatin and its cognate receptors in other tissues, including brain and peripheral ner...

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참고문헌 (77)

  1. Allen M. J. , Shan X. , Caruccio P. , Froggett S. J. , Moffat K. G. and Murphey R. K. ( 1999 ). Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila . J. Neurosci. 19 , 9374 - 9384 . 10531442 

  2. Allen M. J. , Godenschwege T. A. , Tanouye M. A. and Phelan P. ( 2006 ). Making an escape: development and function of the Drosophila giant fibre system . Semin. Cell Dev. Biol. 17 , 31 - 41 . 10.1016/j.semcdb.2005.11.011 16378740 

  3. Augustin H. , Grosjean Y. , Chen K. , Sheng Q. and Featherstone D. E. ( 2007 ). Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo . J. Neurosci. 27 , 111 - 123 . 10.1523/JNEUROSCI.4770-06.2007 17202478 

  4. Augustin H. , Allen M. J. and Partridge L. ( 2011 ). Electrophysiological recordings from the giant fiber pathway of D. melanogaster . J Vis Exp , e2412 10.3791/2412 

  5. Awasaki T. , Huang Y. , O'Connor M. B. and Lee T. ( 2011 ). Glia instruct developmental neuronal remodeling through TGF-beta signaling . Nat. Neurosci. 14 , 821 - 823 . 10.1038/nn.2833 21685919 

  6. Bass T. M. , Grandison R. C. , Wong R. , Martinez P. , Partridge L. and Piper M. D. W. ( 2007 ). Optimization of dietary restriction protocols in Drosophila . J. Gerontol. A Biol. Sci. Med. Sci. 62 , 1071 - 1081 . 10.1093/gerona/62.10.1071 17921418 

  7. Bate M. , Landgraf M. and Ruiz Gomez Bate M. ( 1999 ). Development of larval body wall muscles . Int. Rev. Neurobiol. 43 , 25 - 44 . 10.1016/S0074-7742(08)60539-5 10218153 

  8. Blagburn J. M. , Alexopoulos H. , Davies J. A. and Bacon J. P. ( 1999 ). Null mutation in shaking-B eliminates electrical, but not chemical, synapses in the Drosophila giant fiber system: a structural study . J. Comp. Neurol. 404 , 449 - 458 . 10.1002/(SICI)1096-9861(19990222)404:4 3.0.CO;2-D 9987990 

  9. Böttner M. , Unsicker K. and Suter-Crazzolara C. ( 1996 ). Expression of TGF-beta type II receptor mRNA in the CNS . Neuroreport 7 , 2903 - 2908 . 10.1097/00001756-199611250-00019 9116206 

  10. Bradley C. A. , Peineau S. , Taghibiglou C. , Nicolas C. S. , Whitcomb D. J. , Bortolotto Z. A. , Kaang B.-K. , Cho K. , Wang Y. T. and Collingridge G. L. ( 2012 ). A pivotal role of GSK-3 in synaptic plasticity . Front. Mol. Neurosci. 5 , 13 10.3389/fnmol.2012.00013 22363262 

  11. Brand A. H. and Perrimon N. ( 1993 ). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes . Development 118 , 401 - 415 . 8223268 

  12. Cameron V. A. , Nishimura E. , Mathews L. S. , Lewis K. A. , Sawchenko P. E. and Vale W. W. ( 1994 ). Hybridization histochemical localization of activin receptor subtypes in rat brain, pituitary, ovary, and testis . Endocrinology 134 , 799 - 808 . 10.1210/endo.134.2.8299574 8299574 

  13. Caraci F. , Gulisano W. , Guida C. A. , Impellizzeri A. A. R. , Drago F. , Puzzo D. and Palmeri A. ( 2015 ). A key role for TGF-beta1 in hippocampal synaptic plasticity and memory . Sci. Rep. 5 , 11252 10.1038/srep11252 26059637 

  14. Carnac G. , Vernus B. and Bonnieu A. ( 2007 ). Myostatin in the pathophysiology of skeletal muscle . Curr. Genomics 8 , 415 - 422 . 10.2174/138920207783591672 19412331 

  15. Chen Y. , Guo Q. , Zhang M. , Song S. , Quan T. , Zhao T. , Li H. , Guo L. , Jiang T. and Wang G. ( 2016 ). Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women . Bone Res 4 , 16012 10.1038/boneres.2016.12 27408764 

  16. Church R. B. and Robertson F. W. ( 1966 ). A biochemical study of the growth of Drosophila melanogaster . J. Exp. Zool. 162 , 337 - 351 . 10.1002/jez.1401620309 

  17. Czarkowska-Paczek B. , Bartlomiejczyk I. and Przybylski J. ( 2006 ). The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise . J. Physiol. Pharmacol. 57 , 189 - 197 . 

  18. DiAntonio A. , Petersen S. A. , Heckmann M. and Goodman C. S. ( 1999 ). Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction . J. Neurosci. 19 , 3023 - 3032 . 10191319 

  19. Egerman M. A. , Cadena S. M. , Gilbert J. A. , Meyer A. , Nelson H. N. , Swalley S. E. , Mallozzi C. , Jacobi C. , Jennings L. L. , Clay I. et al. ( 2015 ). GDF11 increases with age and inhibits skeletal muscle regeneration . Cell Metab. 22 , 164 - 174 . 10.1016/j.cmet.2015.05.010 26001423 

  20. Fei Z.-H. , Yao C.-Y. , Yang X.-L. , Huang X.-E. and Ma S.-L. ( 2013 ). Serum BMP-2 up-regulation as an indicator of poor survival in advanced non-small cell lung cancer patients . Asian Pac. J. Cancer Prev. 14 , 5293 - 5299 . 10.7314/APJCP.2013.14.9.5293 24175816 

  21. Franco B. , Bogdanik L. , Bobinnec Y. , Debec A. , Bockaert J. , Parmentier M. L. and Grau Y. ( 2004 ). Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila . J. Neurosci. 24 , 6573 - 6577 . 10.1523/JNEUROSCI.1580-04.2004 15269269 

  22. Fuentes-Medel Y. , Ashley J. , Barria R. , Maloney R. , Freeman M. and Budnik V. ( 2012 ). Integration of a retrograde signal during synapse formation by glia-secreted TGF-beta ligand . Curr. Biol. 22 , 1831 - 1838 . 10.1016/j.cub.2012.07.063 22959350 

  23. Gay S. , Jublanc E. , Bonnieu A. and Bacou F. ( 2012 ). Myostatin deficiency is associated with an increase in number of total axons and motor axons innervating mouse tibialis anterior muscle . Muscle Nerve 45 , 698 - 704 . 10.1002/mus.23242 22499097 

  24. Gentry B. A. , Ferreira J. A. , Phillips C. L. and Brown M. ( 2011 ). Hindlimb skeletal muscle function in myostatin-deficient mice . Muscle Nerve 43 , 49 - 57 . 10.1002/mus.21796 21082689 

  25. Gokoffski K. K. , Wu H.-H. , Beites C. L. , Kim J. , Kim E. J. , Matzuk M. M. , Johnson J. E. , Lander A. D. and Calof A. L. ( 2011 ). Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate . Development 138 , 4131 - 4142 . 10.1242/dev.065870 21852401 

  26. Guo H.-F. and Zhong Y. ( 2006 ). Requirement of Akt to mediate long-term synaptic depression in Drosophila . J. Neurosci. 26 , 4004 - 4014 . 10.1523/JNEUROSCI.3616-05.2006 16611817 

  27. Huang Z. , Chen X. and Chen D. ( 2011 ). Myostatin: a novel insight into its role in metabolism, signal pathways, and expression regulation . Cell. Signal. 23 , 1441 - 1446 . 10.1016/j.cellsig.2011.05.003 21609762 

  28. Iwasaki S. , Miyake M. , Watanabe H. , Kitagawa E. , Watanabe K. , Ohwada S. , Kitazawa H. , Rose M. T. and Aso H. ( 2013 ). Expression of myostatin in neural cells of the olfactory system . Mol. Neurobiol. 47 , 1 - 8 . 10.1007/s12035-012-8342-1 22941030 

  29. Johnson T. K. , Crossman T. , Foote K. A. , Henstridge M. A. , Saligari M. J. , Forbes Beadle L. , Herr A. , Whisstock J. C. and Warr C. G. ( 2013 ). Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing . Proc. Natl. Acad. Sci. USA 110 , 14688 - 14692 . 23959885 

  30. Kamentsky L. , Jones T. R. , Fraser A. , Bray M.-A. , Logan D. J. , Madden K. L. , Ljosa V. , Rueden C. , Eliceiri K. W. and Carpenter A. E. ( 2011 ). Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software . Bioinformatics 27 , 1179 - 1180 . 10.1093/bioinformatics/btr095 21349861 

  31. Kawauchi S. , Kim J. , Santos R. , Wu H.-H. , Lander A. D. and Calof A. L. ( 2009 ). Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11 . Development 136 , 1453 - 1464 . 10.1242/dev.034967 19297409 

  32. Kim M.-J. and O'Connor M. B. ( 2014 ). Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction . PLoS ONE 9 , e107443 10.1371/journal.pone.0107443 25255438 

  33. Kim J. , Wu H. H. , Lander A. D. , Lyons K. M. , Matzuk M. M. and Calof A. L. ( 2005 ). GDF11 controls the timing of progenitor cell competence in developing retina . Science 308 , 1927 - 1930 . 10.1126/science.1110175 15976303 

  34. Kittel R. J. , Wichmann C. , Rasse T. M. , Fouquet W. , Schmidt M. , Schmid A. , Wagh D. A. , Pawlu C. , Kellner R. R. , Willig K. I. et al. ( 2006 ). Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release . Science 312 , 1051 - 1054 . 10.1126/science.1126308 16614170 

  35. Lakshman K. M. , Bhasin S. , Corcoran C. , Collins-Racie L. A. , Tchistiakova L. , Forlow S. B. , St Ledger K. , Burczynski M. E. , Dorner A. J. and Lavallie E. R. ( 2009 ). Measurement of myostatin concentrations in human serum: circulating concentrations in young and older men and effects of testosterone administration . Mol. Cell. Endocrinol. 302 , 26 - 32 . 10.1016/j.mce.2008.12.019 19356623 

  36. Lee S.-J. ( 2004 ). Regulation of muscle mass by myostatin . Annu. Rev. Cell Dev. Biol. 20 , 61 - 86 . 10.1146/annurev.cellbio.20.012103.135836 15473835 

  37. Lee-Hoeflich S. T. , Zhao X. , Mehra A. and Attisano L. ( 2005 ). The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways . FEBS Lett. 579 , 4615 - 4621 . 10.1016/j.febslet.2005.06.088 16098524 

  38. Lein E. S. , Hawrylycz M. J. , Ao N. , Ayres M. , Bensinger A. , Bernard A. , Boe A. F. , Boguski M. S. , Brockway K. S. , Byrnes E. J. et al. ( 2007 ). Genome-wide atlas of gene expression in the adult mouse brain . Nature 445 , 168 - 176 . 10.1038/nature05453 17151600 

  39. Lo P. C. H. and Frasch M. ( 1999 ). Sequence and expression of myoglianin, a novel Drosophila gene of the TGF-beta superfamily . Mech. Dev. 86 , 171 - 175 . 10.1016/S0925-4773(99)00108-2 10446278 

  40. Manceau M. , Gros J. , Savage K. , Thome V. , McPherron A. , Paterson B. and Marcelle C. ( 2008 ). Myostatin promotes the terminal differentiation of embryonic muscle progenitors . Genes Dev. 22 , 668 - 681 . 10.1101/gad.454408 18316481 

  41. Marrus S. B. and DiAntonio A. ( 2004 ). Preferential localization of glutamate receptors opposite sites of high presynaptic release . Curr. Biol. 14 , 924 - 931 . 10.1016/j.cub.2004.05.047 15182665 

  42. McCabe B. D. , Marqués G. , Haghighi A. P. , Fetter R. D. , Crotty M. L. , Haerry T. E. , Goodman C. S. and O'Connor M. B. ( 2003 ). The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction . Neuron 39 , 241 - 254 . 10.1016/S0896-6273(03)00426-4 12873382 

  43. McPherron A. C. , Lawler A. M. and Lee S.-J. ( 1997 ). Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member . Nature 387 , 83 - 90 . 10.1038/387083a0 9139826 

  44. Melom J. E. , Akbergenova Y. , Gavornik J. P. and Littleton J. T. ( 2013 ). Spontaneous and evoked release are independently regulated at individual active zones . J. Neurosci. 33 , 17253 - 17263 . 10.1523/JNEUROSCI.3334-13.2013 24174659 

  45. Nakashima M. , Toyono T. , Akamine A. and Joyner A. ( 1999 ). Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis . Mech. Dev. 80 , 185 - 189 . 10.1016/S0925-4773(98)00205-6 10072786 

  46. Nakashima K. , Takizawa T. , Ochiai W. , Yanagisawa M. , Hisatsune T. , Nakafuku M. , Miyazono K. , Kishimoto T. , Kageyama R. and Taga T. ( 2001 ). BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis . Proc. Natl. Acad. Sci. USA 98 , 5868 - 5873 . 10.1073/pnas.101109698 11331769 

  47. Nelson C. D. , Kim M. J. , Hsin H. , Chen Y. and Sheng M. ( 2013 ). Phosphorylation of threonine-19 of PSD-95 by GSK-3beta is required for PSD-95 mobilization and long-term depression . J. Neurosci. 33 , 12122 - 12135 . 10.1523/JNEUROSCI.0131-13.2013 23864697 

  48. Ng J. ( 2008 ). TGF-beta signals regulate axonal development through distinct Smad-independent mechanisms . Development 135 , 4025 - 4035 . 10.1242/dev.028209 19004854 

  49. Nieland T. J. F. , Logan D. J. , Saulnier J. , Lam D. , Johnson C. , Root D. E. , Carpenter A. E. and Sabatini B. L. ( 2014 ). High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons . PLoS ONE 9 , e91744 10.1371/journal.pone.0091744 24633176 

  50. Oh S. P. , Yeo C. Y. , Lee Y. , Schrewe H. , Whitman M. and Li E. ( 2002 ). Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning . Genes Dev. 16 , 2749 - 2754 . 10.1101/gad.1021802 12414726 

  51. Orr B. O. , Borgen M. A. , Caruccio P. M. and Murphey R. K. ( 2014 ). Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse . J. Neurosci. 34 , 5416 - 5430 . 10.1523/JNEUROSCI.3183-13.2014 24741033 

  52. Peineau S. , Taghibiglou C. , Bradley C. , Wong T. P. , Liu L. , Lu J. , Lo E. , Wu D. , Saule E. , Bouschet T. et al. ( 2007 ). LTP inhibits LTD in the hippocampus via regulation of GSK3beta . Neuron 53 , 703 - 717 . 10.1016/j.neuron.2007.01.029 17329210 

  53. Peineau S. , Nicolas C. S. , Bortolotto Z. A. , Bhat R. V. , Ryves W. J. , Harwood A. J. , Dournaud P. , Fitzjohn S. M. and Collingridge G. L. ( 2009 ). A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases . Mol. Brain 2 , 22 10.1186/1756-6606-2-22 19583853 

  54. Peron S. , Zordan M. A. , Magnabosco A. , Reggiani C. and Megighian A. ( 2009 ). From action potential to contraction: neural control and excitation-contraction coupling in larval muscles of Drosophila . Comp. Biochem. Physiol. A Mol. Integr. Physiol. 154 , 173 - 183 . 10.1016/j.cbpa.2009.04.626 19427393 

  55. Petersen S. A. , Fetter R. D. , Noordermeer J. N. , Goodman C. S. and DiAntonio A. ( 1997 ). Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release . Neuron 19 , 1237 - 1248 . 10.1016/S0896-6273(00)80415-8 9427247 

  56. Peterson A. J. , Jensen P. A. , Shimell M. J. , Stefancsik R. , Wijayatonge R. , Herder R. , Raftery L. A. and O'Connor M. B. ( 2012 ). R-Smad competition controls activin receptor output in Drosophila . PLoS ONE 7 , e36548 10.1371/journal.pone.0036548 22563507 

  57. Piccirillo R. , Demontis F. , Perrimon N. and Goldberg A. L. ( 2014 ). Mechanisms of muscle growth and atrophy in mammals and Drosophila . Dev. Dyn. 243 , 201 - 215 . 10.1002/dvdy.24036 24038488 

  58. Ramesh C. , Pohl R. , Balon R. and Yeragani V. K. ( 1990 ). Effect of imipramine on liver function tests . Pharmacopsychiatry 23 , 56 - 57 . 2315377 

  59. Ranganayakulu G. , Zhao B. , Dokidis A. , Molkentin J. D. , Olson E. N. and Schulz R. A. ( 1995 ). A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila . Dev. Biol. 171 , 169 - 181 . 10.1006/dbio.1995.1269 7556894 

  60. Rebbapragada A. , Benchabane H. , Wrana J. L. , Celeste A. J. and Attisano L. ( 2003 ). Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis . Mol. Cell. Biol. 23 , 7230 - 7242 . 10.1128/MCB.23.20.7230-7242.2003 14517293 

  61. Renden R. B. and Broadie K. ( 2003 ). Mutation and activation of Galpha s similarly alters pre- and postsynaptic mechanisms modulating neurotransmission . J. Neurophysiol. 89 , 2620 - 2638 . 10.1152/jn.01072.2002 12611964 

  62. Robinson S. W. , Nugent M. L. , Dinsdale D. and Steinert J. R. ( 2014 ). Prion protein facilitates synaptic vesicle release by enhancing release probability . Hum. Mol. Genet. 23 , 4581 - 4596 . 10.1093/hmg/ddu171 24722203 

  63. Ruiz-Cañada C. and Budnik V. ( 2006 ). Introduction on the use of the Drosophila embryonic/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition . Int. Rev. Neurobiol. 75 , 1 - 31 . 10.1016/S0074-7742(06)75001-2 17137921 

  64. Salcedo-Tello P. , Ortiz-Matamoros A. and Arias C. ( 2011 ). GSK3 function in the brain during development, neuronal plasticity, and neurodegeneration . Int. J. Alzheimers Dis. 2011 , 189728 10.4061/2011/189728 21660241 

  65. Schafer M. J. , Atkinson E. J. , Vanderboom P. M. , Kotajarvi B. , White T. A. , Moore M. M. , Bruce C. J. , Greason K. L. , Suri R. M. , Khosla S. et al. ( 2016 ). Quantification of GDF11 and myostatin in human aging and cardiovascular disease . Cell Metab. 23 , 1207 - 1215 . 10.1016/j.cmet.2016.05.023 27304512 

  66. Shi Y. and Liu J.-P. ( 2011 ). Gdf11 facilitates temporal progression of neurogenesis in the developing spinal cord . J. Neurosci. 31 , 883 - 893 . 10.1523/JNEUROSCI.2394-10.2011 21248112 

  67. Sigrist S. J. , Thiel P. R. , Reiff D. F. and Schuster C. M. ( 2002 ). The postsynaptic glutamate receptor subunit DGluR-IIA mediates long-term plasticity in Drosophila . J. Neurosci. 22 , 7362 - 7372 . 12196557 

  68. Szulc P. , Schoppet M. , Goettsch C. , Rauner M. , Dschietzig T. , Chapurlat R. and Hofbauer L. C. ( 2012 ). Endocrine and clinical correlates of myostatin serum concentration in men--the STRAMBO study . J. Clin. Endocrinol. Metab. 97 , 3700 - 3708 . 10.1210/jc.2012-1273 22802085 

  69. Tanouye M. A. and Wyman R. J. ( 1980 ). Motor outputs of giant nerve fiber in Drosophila . J. Neurophysiol. 44 , 405 - 421 . 6774064 

  70. Van der Zee M. , da Fonseca R. N. and Roth S. ( 2008 ). TGFbeta signaling in Tribolium: vertebrate-like components in a beetle . Dev. Genes Evol. 218 , 203 - 213 . 10.1007/s00427-007-0179-7 18392881 

  71. Viquez N. M. , Fuger P. , Valakh V. , Daniels R. W. , Rasse T. M. and DiAntonio A. ( 2009 ). PP2A and GSK-3beta act antagonistically to regulate active zone development . J. Neurosci. 29 , 11484 - 11494 . 10.1523/JNEUROSCI.5584-08.2009 19759297 

  72. Vyas D. R. , Spangenburg E. E. , Abraha T. W. , Childs T. E. and Booth F. W. ( 2002 ). GSK-3beta negatively regulates skeletal myotube hypertrophy . Am. J. Physiol. Cell Physiol. 283 , C545 - C551 . 10.1152/ajpcell.00049.2002 12107064 

  73. Wei J. , Liu W. and Yan Z. ( 2010 ). Regulation of AMPA receptor trafficking and function by glycogen synthase kinase 3 . J. Biol. Chem. 285 , 26369 - 26376 . 10.1074/jbc.M110.121376 20584904 

  74. Weyhersmuller A. , Hallermann S. , Wagner N. and Eilers J. ( 2011 ). Rapid active zone remodeling during synaptic plasticity . J. Neurosci. 31 , 6041 - 6052 . 10.1523/JNEUROSCI.6698-10.2011 21508229 

  75. Wu H.-H. , Ivkovic S. , Murray R. C. , Jaramillo S. , Lyons K. M. , Johnson J. E. and Calof A. L. ( 2003 ). Autoregulation of neurogenesis by GDF11 . Neuron 37 , 197 - 207 . 10.1016/S0896-6273(02)01172-8 12546816 

  76. Yu X. M. , Gutman I. , Mosca T. J. , Iram T. , Özkan E. , Garcia K. C. , Luo L. and Schuldiner O. ( 2013 ). Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-beta signaling . Neuron 78 , 456 - 468 . 10.1016/j.neuron.2013.03.004 23664613 

  77. Zhang F. , Endo S. , Cleary L. J. , Eskin A. and Byrne J. H. ( 1997 ). Role of transforming growth factor-beta in long-term synaptic facilitation in Aplysia . Science 275 , 1318 - 1320 . 10.1126/science.275.5304.1318 9036859 

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