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Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death

Brain research bulletin, v.134, 2017년, pp.63 - 71  

Kim, Arum (Corresponding author at: Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156, 756, Republic of Korea) ,  Nam, Yoon Jeong ,  Lee, Chung Soo

Abstract AI-Helper 아이콘AI-Helper

Abstract The taxifolin effect on the cholesterol oxidation product-induced neuronal apoptosis was investigated using differentiated PC12 cells and human neuroblastoma SH-SY5Y cells. 7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-κB p65...

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