[논문]Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase

Kim, Y.J.; Hwang, S.H.; Jia, Y.; Seo, W.D.; Lee, S.J.

doi:10.1016/j.foodres.2017.08.068

Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase

Food research international, v.101, 2017년, pp.209 - 217

Kim, Y.J. , Hwang, S.H. , Jia, Y. , Seo, W.D. , Lee, S.J.

Abstract ▼ AI-Helper

Chronic alcohol consumption leads to hepatic lipid accumulation and alcoholic fatty liver disease. Previously, we demonstrated that barley sprout extract, which contains saponarin as an active compound, reduces hepatic steatosis. In this study, we investigated the effect of barley sprout extracts (BSE) on hepatic lipid accumulation in a mouse model of alcoholic fatty liver disease. Seven-week-old C57BL/6 mice were fed an alcohol-containing diet (5% ethanol) and a low or high dose of BSE (100 or 200 mg/kg body weight, respectively) for 10 days. The high dose of BSE significantly decreased hepatic lipid accumulation compared with the ethanol-only control group. In the second animal study, mice were fed an alcohol-containing diet for 10 days, followed by a 45% high fat diet with oral administration of BSE (100 or 200 mg/day/kg body weight) for 4 weeks. Mice in both BSE-fed groups showed reduced hepatic steatosis. In the livers of mice fed BSE, phosphorylation of AMP-activated protein kinase (AMPK) was increased, and expression of hepatic autophagy markers was elevated. In cultured hepatocytes, BSE (200 (mu g/mL) increased the rate of fatty acid oxidation and reduced that of fatty acid synthesis. Taken together, these findings suggest that BSE promotes degradation of lipid droplets and subsequent activation of fat oxidation by activating AMPK in the liver, thus protecting against development of hepatic steatosis in alcohol-fed mice. Saponarin, a major flavonoid in BSE and an activator of AMPK, increased the activity of microsomal triglyceride transfer protein, which suggests that the reduction in hepatic triglyceride levels was mediated by this component of BSE. In conclusion, BSE ameliorated hepatic steatosis in a mouse model of ethanol-induced fatty liver by activating AMPK, an effect possibly mediated by the saponarin component.

주제어

참고문헌 (34)

American Journal of Physiology. Gastrointestinal and Liver Physiology Ajmo 295 4 G833 2008 10.1152/ajpgi.90358.2008 Resveratrol alleviates alcoholic fatty liver in mice

상세보기
Pharmacological Reviews Anderson 60 3 311 2008 10.1124/pr.108.00001 Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis

상세보기
Best Practice & Research Clinical Gastroenterology Arteel 17 4 625 2003 10.1016/S1521-6918(03)00053-2 Advances in alcoholic liver disease

상세보기
Nature Protocols Bertola 8 3 627 2013 10.1038/nprot.2013.032 Mouse model of chronic and binge ethanol feeding (the NIAAA model)

상세보기
Alcohol Diehl 27 1 7 2002 10.1016/S0741-8329(02)00204-5 Liver disease in alcohol abusers: Clinical perspective

상세보기
Experimental Biology and Medicine Ding 236 5 546 2011 10.1258/ebm.2011.010360 The emerging role of autophagy in alcoholic liver disease

상세보기
Gastroenterology Gao 141 5 1572 2011 10.1053/j.gastro.2011.09.002 Alcoholic liver disease: Pathogenesis and new therapeutic targets

상세보기
International Journal of Obesity Hardie 32 S7 2008 10.1038/ijo.2008.116 AMPK: A key regulator of energy balance in the single cell and the whole organism

상세보기
Bioorganic & Medicinal Chemistry Letters Jia 21 19 5876 2011 10.1016/j.bmcl.2011.07.095 Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism

상세보기
Journal of Nutritional Biochemistry Jia 28 9 2016 10.1016/j.jnutbio.2015.09.015 Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt

상세보기
Journal of Lipid Research Jun 55 6 1098 2014 10.1194/jlr.M045807 Linalool is a PPAR alpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome

상세보기
Food Research International Kim 53 1 373 2013 10.1016/j.foodres.2013.05.001 Metabolic profiling and biological mechanisms of body fat reduction in mice fed the ethanolic extract of black-colored rice

상세보기
Journal of Food Biochemistry Kim 40 2 235 2016 10.1111/jfbc.12210 Black Rice (Oryza Sativa, Heukmi) extracts stimulate osteogenesis but inhibit adipogenesis in mesenchymal C3H10T1/2 cells

상세보기
Food Research International Lee 72 174 2015 10.1016/j.foodres.2015.03.041 Barley sprout extract containing policosanols and polyphenols regulate AMPK, SREBP2 and ACAT2 activity and cholesterol and glucose metabolism in vitro and in vivo

상세보기
Nutrients Lee 8 7 440 2016 10.3390/nu8070440 Barley sprouts extract attenuates alcoholic fatty liver injury in mice by reducing inflammatory response

상세보기
Drug Safety Lin 37 4 213 2014 10.1007/s40264-014-0147-x Potential approaches to ameliorate hepatic fat accumulation seen with MTP inhibition

상세보기
Journal of Nutrition Liu 144 7 1009 2014 10.3945/jn.114.193128 Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice

상세보기
Hepatology Research Livero 46 1 111 2016 10.1111/hepr.12594 Molecular basis of alcoholic fatty liver disease: From incidence to treatment

상세보기
Nature Reviews Gastroenterology & Hepatology Louvet 12 4 231 2015 10.1038/nrgastro.2015.35 Alcoholic liver disease: Mechanisms of injury and targeted treatment

상세보기
Nature Cell Biology Mihaylova 13 9 1016 2011 10.1038/ncb2329 The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

상세보기
Biochemical and Biophysical Research Communications Noh 414 2 361 2011 10.1016/j.bbrc.2011.09.077 Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase

상세보기
Journal of Agricultural Science Park 7 10 1916 2015 10.5539/jas.v7n10p94 The antioxidant properties of four Korean barley cultivars at different harvest times and profiling of major metabolites
American Journal of Physiology - Gastrointestinal and Liver Physiology Reddy 290 5 G852 2006 10.1152/ajpgi.00521.2005 Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation

상세보기
British Journal of Nutrition Seo 117 2 177 2017 10.1017/S0007114516004621 Fermented green tea extract exhibits hypolipidaemic effects through the inhibition of pancreatic lipase and promotion of energy expenditure

상세보기
Bioorganic & Medicinal Chemistry Letters Seo 25 22 5237 2015 10.1016/j.bmcl.2015.09.057 Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5

상세보기
Journal of Agricultural and Food Chemistry Seo 61 5 1117 2013 10.1021/jf3041879 Effect of the growth stage and cultivar on policosanol profiles of barley sprouts and their adenosine 5′-monophosphate-activated protein kinase activation

상세보기
Nature Singh 458 7242 1131 2009 10.1038/nature07976 Autophagy regulates lipid metabolism

상세보기
Methods in Enzymology Singleton 299 152 1999 10.1016/S0076-6879(99)99017-1 Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent
Current Obesity Reports Traversy 4 1 122 2015 10.1007/s13679-014-0129-4 Alcohol consumption and obesity: An update

상세보기
Journal of Physiology (London) Viollet 574 1 41 2006 10.1113/jphysiol.2006.108506 Activation of AMP-activated protein kinase in the liver: A new strategy for the management of metabolic hepatic disorders

상세보기
Hepatology Williams 44 3 521 2006 10.1002/hep.21347 Global challenges in liver disease

상세보기
International Journal of Biochemistry & Cell Biology Wu 64 75 2015 10.1016/j.biocel.2015.03.008 Activation of OR1A1 suppresses PPAR-gamma expression by inducing HES-1 in cultured hepatocytes

상세보기
Gastroenterology Yeh 147 4 754 2014 10.1053/j.gastro.2014.07.056 Pathological features of fatty liver disease

상세보기
Alcohol You 34 1 39 2004 10.1016/j.alcohol.2004.07.004 Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins

상세보기

LOADING...

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase

Abstract ▼ AI-Helper

주제어

참고문헌 (34)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

연관된 기능

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase

Abstract ▼ AI-Helper

주제어

참고문헌 (34)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

연관된 기능

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트