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Journal of organic chemistry, v.83 no.1, 2018년, pp.185 - 193
Ishikawa, Fumihiro (State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009,) , Jinno, Kazumi , Kinouchi, Eri , Ninomiya, Kiyofumi , Marumoto, Shinsuke , Xie, Weijia , Muraoka, Osamu , Morikawa, Toshio , Tanabe, Genzoh
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A facile and highly diastereoselective approach toward the synthesis of potent salacinol-type α-glucosidase inhibitors, originally isolated from plants of the genus “Salacia”, was developed using the S-alkylation of thiosugars with epoxides in HFIP (∼90%, dr, α/β = &...
Yoshikawa, Masayuki, Murakami, Toshiyuki, Shimada, Hiromi, Matsuda, Hisashi, Yamahara, Johji, Tanabe, Genzou, Muraoka, Osamu. Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the Ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India. Tetrahedron letters: the international organ for the rapid publication of preliminary communications in organic chemistry, vol.38, no.48, 8367-8370.
Yoshikawa, M., Morikawa, T., Matsuda, H., Tanabe, G., Muraoka, O.. Absolute Stereostructure of Potent α-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata. Bioorganic & medicinal chemistry, vol.10, no.5, 1547-1554.
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Sim, Lyann, Willemsma, Carly, Mohan, Sankar, Naim, Hassan Y., Pinto, B. Mario, Rose, David R.. Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains. The Journal of biological chemistry, vol.285, no.23, 17763-17770.
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Morikawa, Toshio, Akaki, Junji, Ninomiya, Kiyofumi, Kinouchi, Eri, Tanabe, Genzoh, Pongpiriyadacha, Yutana, Yoshikawa, Masayuki, Muraoka, Osamu. Salacinol and Related Analogs: New Leads for Type 2 Diabetes Therapeutic Candidates from the Thai Traditional Natural Medicine Salacia chinensis. Nutrients, vol.7, no.3, 1480-1493.
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