$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception

Regulatory toxicology and pharmacology : RTP, v.91, 2017년, pp.216 - 225  

Sharma, Anjna (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Magotra, Asmita (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Dogra, Ashish (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Rath, Santosh Kumar (Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Rayees, Sheikh (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Wazir, Priya (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Sharma, Sadhana (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Sangwan, Payare Lal (Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Singh, Surjeet (PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180 001, India) ,  Singh, Gurdarshan ,  Nandi, Utpal

Abstract AI-Helper 아이콘AI-Helper

Abstract In spite of unprecedented advances in modern systems of medicine, there is necessity for exploration of traditional plant based secondary metabolites or their semisynthetic derivatives which may results in better therapeutic activity, low toxicity and favourable pharmacokinetics. In this c...

주제어

참고문헌 (46)

  1. Bioorg. Med. Chem. Aga 25 2017 10.1016/j.bmc.2017.01.006 Synthesis of ofornine mimics from natural product l-vasicine as anti-hypertensive agents 

  2. Pharmacogn. Rev. Beg 5 120 2011 10.4103/0973-7847.91102 Systematic review of herbals as potential antiinflammatory agents: recent advances, current clinical status and future perspectives 

  3. Adv. Drug Deliv. Rev. Bergstrom 101 6 2016 10.1016/j.addr.2016.02.005 Computational prediction of formulation strategies for beyond-rule-of-5 compounds 

  4. Basic Clin. Pharmacol. Toxicol. Bergstrom 96 156 2005 10.1111/j.1742-7843.2005.pto960303.x In-silico predictions of drug solubility and permeability: two rate-limiting barriers to oral drug absorption 

  5. Org. Biomol. Chem. Bharate 13 5488 2015 10.1039/C5OB00554J Synthesis and P-glycoprotein induction activity of colupulone analogs 

  6. Bioorg. Med. Chem. Lett. Bharate 1 1561 2015 10.1016/j.bmcl.2015.02.013 Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery 

  7. Drug Res. Chhonker 64 1 2014 Pharmacokinetics, tissue distribution and plasma protein binding studies of rohitukine: a potent anti-hyperlipidemic agent 

  8. Evid. -Based Complement. Altern. Med. Choi 1 2014 Gastrodiae rhizoma ethanol extract enhances pentobarbital-induced sleeping behaviors and rapid eye movement sleep via the activation of GABAA-ergic transmission in rodents 

  9. Int. J. Pharm. Choudhury 460 131 2014 10.1016/j.ijpharm.2013.10.055 Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform 

  10. Metabolites Daniel 2 303 2012 10.3390/metabo2020303 A historical overview of natural products in drug discovery 

  11. Fundam. Clin. Pharmacol. de Sousa 1 2011 A report of a galactan from marine alga Gelidium crinale with in vivo antiinflammatory and antinociceptive effects 

  12. Inflammopharmacol Ekambaram 25 147 2017 10.1007/s10787-016-0303-2 Antiinflammatory effect of Naravelia zeylanica DC via suppression of inflammatory mediators in carrageenan-induced abdominal oedema in zebrafish model 

  13. Food Chem. Toxicol. Eun 50 1309 2012 10.1016/j.fct.2012.02.011 Antiinflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated Raw 264.7 macrophages 

  14. Drug Metab. Dispos. Giuliano 33 1319 2005 10.1124/dmd.105.005033 Direct determination of unbound intrinsic drug clearance in the microsomal stability assay 

  15. Fed. Regist. ICH, S7A 66 36791 2001 Safety pharmacology studies for human pharmaceutical 

  16. J. Med. Chem. Jain 57 7085 2014 10.1021/jm500901e Pyrano-isochromanones as IL-6 inhibitors: synthesis, in vitro and in vivo antiarthritic activity 

  17. Curr. Pharm. Biotechnol. Jason 4 270 2003 10.2174/1389201033489766 Peripheral opioid analgesia 

  18. Kerns 56 2008 Solubility. In Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization 

  19. J. Pharm. Sci. Kerns 90 1838 2001 10.1002/jps.1134 High throughput physicochemical profiling for drug discovery 

  20. Br. J. Anaesth. Kidd 87 3 2001 10.1093/bja/87.1.3 Mechanisms of inflammatory pain 

  21. Drug Metab. Rev. Kim 34 47 2002 10.1081/DMR-120001389 Drugs as P-glycoprotein substrates, inhibitors, and inducers 

  22. J. Vet. Sci. Kim 5 309 2004 10.4142/jvs.2004.5.4.309 General pharmacological profiles of bee venom and its water soluble fractions in rodent models 

  23. Bioorg. Med. Chem. Lett. Kumar 1 3457 2016 10.1016/j.bmcl.2016.06.046 A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties 

  24. Biomed. Chromatogr. Meng 20 951 2006 10.1002/bmc.626 Pharmacokinetic study of p-coumaric acid in mouse after oral administration of extract of Ananas comosus L. leaves 

  25. J. Biol. Sci. Mondal 8 1110 2008 10.3923/jbs.2008.1110.1114 Optimization of rat liver microsomal stability assay using HPLC 

  26. Indian J. Pharmacol Mondal 41 176 2009 10.4103/0253-7613.56075 Determination of drug-like properties of a novel antileishmanial compound: In vitro absorption, distribution, metabolism, and excretion studies 

  27. Org. Biomol. Chem. Mudududdla 13 4296 2015 10.1039/C5OB00233H 3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl) thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity 

  28. RSC Adv. Nalli 14 3322 2016 Four new carbazole alkaloids from Murraya koenigii that display antiinflammatory and anti-microbial activities 

  29. J. Sci. Food Agric. Pei 96 2952 2016 10.1002/jsfa.7578 p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities 

  30. Rheumatol. Int. Pragasam 33 325 2013 10.1007/s00296-012-2394-4 Ameliorative effect of p-coumaric acid, a common dietary phenol, on adjuvant-induced arthritis in rats 

  31. J. Pharm. Pharmceut Sci. Rao 11 81 2008 10.18433/J3T886 Evolution of nonsteroidal antiinflammatory drugs (NSAIDS): cyclooxygenase (COX) inhibition and beyond 

  32. Environ. Toxicol. Pharmacol. Rayees 35 347 2013 10.1016/j.etap.2012.08.007 Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-pentadienoic acid piperidide (SK-20): a novel drug bioavailability enhancer 

  33. J. ethanopharmacol Semnani 80 181 2002 10.1016/S0378-8741(02)00027-2 Anti- inflammatory, analgesic activity and acute toxicity of Glaucium grandiflorum extract 

  34. J Pharm Investig. Sharma 2017 10.1007/s40005-017-0350-8 In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC-ESI-MS/MS method in mice plasma 

  35. Curr. Drug Metab. Singh 7 165 2006 10.2174/138920006775541552 Preclinical pharmacokinetics: an approach towards safer and efficacious drugs 

  36. J. Bioequiv Availab. Singh S14 1 2012 Rapid equilibrium dialysis (RED): an in-vitro high-throughput screening technique for plasma protein binding using human and rat plasma 

  37. Nat. Rev. Drug Discov. Smith 9 929 2010 10.1038/nrd3287 The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery 

  38. Arthritis Rheum. Sokka 48 59 2003 10.1002/art.10731 Functional disability in rheumatoid arthritis patients compared with a community population in Finland 

  39. Neurosci. Lett. Sommer 361 184 2004 10.1016/j.neulet.2003.12.007 Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia 

  40. Acta Pharmacol. Sin. Sun 25 121 2004 In vitro identification of metabolites of verapamil in rat liver microsomes 

  41. Indian. J. Pharmacol. Wani 44 493 2012 10.4103/0253-7613.99322 Analgesic activity of the ethanolic extract of Shorea robusta resin in experimental animals 

  42. Eur. J. Pharmacol. Wesolowska 495 129 2004 10.1016/j.ejphar.2004.05.028 MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay 

  43. J. Med. Chem. Wohnsland 44 923 2001 10.1021/jm001020e High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes 

  44. Med. Chem. Ya 6 327 2016 Antiinflammatory effects of p-coumaric acid in LPS-stimulated RAW264.7 cells: involvement of NF-κB and MAPKS pathways 

  45. BMC Complement. Altern. Med. Yacob 16 303 2016 10.1186/s12906-016-1277-8 Antidiarrheal activity of 80% methanol extract of the aerial part of Ajuga remota Benth (Laminaceace) in mice 

  46. J. Pharmacol. Toxicol. Methods Yeung 45 235 2001 10.1016/S1056-8719(01)00155-1 A simple method to investigate the inhibitory effects of drugs on gastric emptying in the mouse in vivo 

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로