[논문]Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure: a prospective, single-blind, randomized, controlled, and multicenter clinical trial

Xianliang, Wang; Yazhu, Hou; Jingyuan, Mao; Yingqiang, Zhao; Tianfu, Niu; Ruyu, Yuan; Yonggang, Wang; Jinrong, Cui; Le, Shi; Xiuli, Jia; Ruihong, Fan; Qian, Lin; Yan, Zhang; Zhijun, Li; Hongcai, Shang; Baohe, Wang; Hongwu, Wang; Henghe, Wang; Xiaolei, Cui; Shanbin, Soh; Jishou, Ruan; Boli, Zhang

doi:10.1016/S0254-6272(18)30038-4

Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure: a prospective, single-blind, randomized, controlled, and multicenter clinical trial 원문보기

Journal of traditional Chinese medicine = 中醫雜誌, v.37 no.6, 2017년, pp.756 - 766

Xianliang, Wang (Cardiovascular Department, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) , Yazhu, Hou (Cardiovascular Department, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) , Jingyuan, Mao (Cardiovascular Department, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) , Yingqiang, Zhao (Cardiovascular Department, the Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China) , Tianfu, Niu (Cardiovascular Department, Shanxi Traditional Chinese Medicine Institute, Taiyuan 030012, China) , Ruyu, Yuan (Cardiovascular Department, the Second Teaching Hospital of Tianjin Medical University, Tianjin 300211, China) , Yonggang, Wang (Cardiovascular Department, the Second Teaching Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China) , Jinrong, Cui (Cardiovascular Department, the Integrated Hospitals of TCM and Western Medicine of Shanxi University of Traditional Chi) , Le, Shi , Xiuli, Jia , Ruihong, Fan , Qian, Lin , Yan, Zhang , Zhijun, Li , Hongcai, Shang , Baohe, Wang , Hongwu, Wang , Henghe, Wang , Xiaolei, Cui , Shanbin, Soh , Jishou, Ruan , Boli, Zhang

Abstract ▼ AI-Helper

Abstract Objective To assess the efficacy and safety in patients with chronic heart failure (CHF) of Western medication plus Traditional Chinese Medicine (TCM) preparations. Methods This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40–79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge, all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality. The efficacy assessments were as follows: B-type natriuretic peptide (BNP), Lee's HF score, the 6-minute walking test (6MWT), left ventricular ejection fraction (LVEF), and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events. Results Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate. The treatment group showed greater improvement in 6MWT (P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ (P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups. Conclusion Western medication plus TCM treatment can increase 6-minute walking distance (improve exercise tolerance) and quality of life with heart failure patients.

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참고문헌 (16)

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Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure: a prospective, single-blind, randomized, controlled, and multicenter clinical trial 원문보기

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