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NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation 원문보기

Cell reports, v.23 no.13, 2018년, pp.3839 - 3851  

Um, Seung Min (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Ha, Seungmin (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Lee, Hyejin (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)) ,  Kim, Jihye (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)) ,  Kim, Kyungdeok (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Shin, Wangyong (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Cho, Yi Sul (Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University) ,  Roh, Junyeop Daniel (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Kang, Jaeseung (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (I) ,  Yoo, Taesun ,  Noh, Young Woo ,  Choi, Yeonsoo ,  Bae, Yong Chul ,  Kim, Eunjoon

Abstract AI-Helper 아이콘AI-Helper

Summary Netrin-G ligand 2 (NGL-2)/LRRC4, implicated in autism spectrum disorders and schizophrenia, is a leucine-rich repeat-containing postsynaptic adhesion molecule that interacts intracellularly with the excitatory postsynaptic scaffolding protein PSD-95 and trans-synaptically with the presynapt...

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