[논문]Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee

Kim, Moon Jin; Kim, Young Sam; Oh, Sung Yong; Lee, Suee; Choi, Young-Jin; Seol, Young Mi; Park, Min Jae; Kim, Ki Hyang; Park, Lee Chun; Kang, Jung Hun; Hwang, In-Gyu; Lee, Soon Il; Lim, Seung Taek; Kim, Hyo Song; Lim, Ho Yeong; Rha, Sun Young; Kim, Hyo-Jin

doi:10.3904/kjim.2015.162

Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee 원문보기

The Korean journal of internal medicine : KJIM, v.33 no.2, 2018년, pp.383 - 390

Kim, Moon Jin (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea) , Kim, Young Sam (Dong-A University Hospital, Busan, Korea) , Oh, Sung Yong (Dong-A University Hospital, Busan, Korea) , Lee, Suee (Dong-A University Hospital, Busan, Korea) , Choi, Young-Jin (Pusan National University Hospital, Busan, Korea) , Seol, Young Mi (Pusan National University Hospital, Busan, Korea) , Park, Min Jae (Pusan National University Yangsan Hospital, Yangsan, Korea) , Kim, Ki Hyang (Inje University Busan Paik Hospital, Busan, Korea) , Park, Lee Chun (Kosin University College of Medicine, Busan, Korea) , Kang, Jung Hun (Gyeongsang National University Hospital, Jinju, Korea) , Hwang, In-Gyu (Chung-Ang University College of Medicine, Seoul, Korea) , Lee, Soon Il (Dankook University College of Medicine, Cheonan, Korea) , Lim, Seung Taek (Konya) , Kim, Hyo Song , Lim, Ho Yeong , Rha, Sun Young , Kim, Hyo-Jin

Abstract ▼ AI-Helper

Background/Aims:Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma.Methods:Eligible patients for this retrospective analysis were initially diagnosed with bladder adenocarcinoma and presented with a clinically no other primary site of origin. The collected data included age, gender, performance status, stage, hemoglobin, albumin, initial date of diagnosis, treatment modality utilized, response to treatment, presence of relapse, last status of patient, and last date of follow-up.Results:We retrospectively reviewed 29 patients, who were treated with chemotherapy for bladder adenocarcinoma at 10 Korean medical institutions from 2004 to 2014. The median age of patients was 58 years (range, 17 to 78) and 51.7% of the patients were female. Urachal adenocarcinoma was identified in 15 patients. Of 27 symptomatic patients, 22 experienced gross hematuria. Twelve patients were treated with 5-f luorouracil based chemotherapy, five were gemcitabine based, three were taxane and others. Thirteen of them achieved complete response (10.3%) or partial response (34.5%). Median progression-free survival (PFS) and overall survival (OS) for all patients were 10.6 months (95% confidence interval [CI], 9.5 to 11.6) and 24.5 months (95% CI, 1.2 to 47.8), respectively. The cases of urachal adenocarcinoma exhibited worse tendency in PFS and OS (p = 0.024 and p = 0.046, respectively).Conclusions:Even though bladder adenocarcinoma had been observed moderate effectiveness to chemotherapy, bladder adenocarcinoma is a highly aggressive form of bladder cancer. PFS and OS were short especially in urachal carcinoma.

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참고문헌 (22)

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DOI : 10.3904/kjim.2015.162
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