최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Stem cell research & therapy, v.8 no.1, 2017년, pp.111 -
Duncan, Thomas (Regenerative Neuroscience Group, Brain and Mind Centre & Sydney Medical School, University of Sydney, Sydney, NSW 2050 Australia) , Valenzuela, Michael (Regenerative Neuroscience Group, Brain and Mind Centre & Sydney Medical School, University of Sydney, Sydney, NSW 2050 Australia)
Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuit...
1. Alzheimers Association 2015 Alzheimer’s disease facts and figures Alzheimers Dement 2015 11 332 10.1016/j.jalz.2015.02.003 25984581
2. Salloway S Sperling R Fox NC Blennow K Klunk W Raskind M Sabbagh M Honig LS Porsteinsson AP Ferris S Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer’s disease N Engl J Med. 2014 370 322 33 10.1056/NEJMoa1304839 24450891
3. Doody RS Raman R Farlow M Iwatsubo T Vellas B Joffe S Kieburtz K He F Sun X Thomas RG A phase 3 trial of semagacestat for treatment of Alzheimer’s disease N Engl J Med. 2013 369 341 50 10.1056/NEJMoa1210951 23883379
4. Walker D Lue LF Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer’s disease and other neurodegenerative diseases J Neurosci Res. 2005 81 412 25 10.1002/jnr.20484 15957156
5. Delbeuck X Van der Linden M Collette F Alzheimer’s disease as a disconnection syndrome? Neuropsychol Rev. 2003 13 79 92 10.1023/A:1023832305702 12887040
6. Hass R Kasper C Böhm S Jacobs R Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC Cell Commun Signal. 2011 9 1 10.1186/1478-811X-9-12 21223562
7. Takahashi K Yamanaka S Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell. 2006 126 663 76 10.1016/j.cell.2006.07.024 16904174
8. Jin K Zhu Y Sun Y Mao XO Xie L Greenberg DA Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo Proc Natl Acad Sci. 2002 99 11946 50 10.1073/pnas.182296499 12181492
9. Lopez-Toledano MA Shelanski ML Increased neurogenesis in young transgenic mice overexpressing human APP J Alzheimers Dis. 2007 12 229 40 10.3233/JAD-2007-12304 18057556
10. Donovan MH Yazdani U Norris RD Games D German DC Eisch AJ Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer’s disease J Comp Neurol. 2006 495 70 83 10.1002/cne.20840 16432899
11. Acharya MM Christie L-A Lan ML Donovan PJ Cotman CW Fike JR Limoli CL Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells Proc Natl Acad Sci. 2009 106 19150 5 10.1073/pnas.0909293106 19901336
12. Fong CY Gauthaman K Bongso A Teratomas from pluripotent stem cells: a clinical hurdle J Cell Biochem. 2010 111 769 81 10.1002/jcb.22775 20665544
13. Moghadam FH Alaie H Karbalaie K Tanhaei S Esfahani MHN Baharvand H Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats Differentiation. 2009 78 59 68 10.1016/j.diff.2009.06.005 19616885
14. Bissonnette CJ Lyass L Bhattacharyya BJ Belmadani A Miller RJ Kessler JA The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells Stem Cells. 2011 29 802 11 10.1002/stem.626 21381151
15. Liu Y Weick JP Liu H Krencik R Zhang X Ma L Zhou G-m Ayala M Zhang S-C Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits Nat Biotechnol. 2013 31 440 7 10.1038/nbt.2565 23604284
16. Blurton-Jones M Kitazawa M Martinez-Coria H Castello NA Müller F-J Loring JF Yamasaki TR Poon WW Green KN LaFerla FM Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease Proc Natl Acad Sci. 2009 106 13594 9 10.1073/pnas.0901402106 19633196
17. Kordower JH Winn SR Liu Y-T Mufson EJ Sladek JR Hammang JP Baetge EE Emerich DF The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor Proc Natl Acad Sci. 1994 91 10898 902 10.1073/pnas.91.23.10898 7971980
18. Park D Yang Y-H Bae DK Lee SH Yang G Kyung J Kim D Choi E-K Lee SW Kim GH Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase Neurobiol Aging. 2013 34 2639 46 10.1016/j.neurobiolaging.2013.04.026 23731954
19. Zhang Q, Wu Hh, Wang Y, Gu Gj, Zhang W, Xia R. Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer’s disease. J Neurochem. 2015;136:815–825.
20. Lee I-S Jung K Kim I-S Lee H Kim M Yun S Hwang K Shin JE Park KI Human neural stem cells alleviate Alzheimer-like pathology in a mouse model Mol Neurodegener. 2015 10 1 10.1186/s13024-015-0035-6 25567526
21. Lilja AM, Malmsten L, Röjdner J, Voytenko L, Verkhratsky A, Ögren SO, Nordberg A, Marutle A. Neural stem cell transplant-induced effect on neurogenesis and cognition in Alzheimer Tg2576 mice is inhibited by concomitant treatment with amyloid-lowering or cholinergic 7 nicotinic receptor drugs. Neural Plast. 2015;2015:370432.
22. Ager RR Davis JL Agazaryan A Benavente F Poon WW LaFerla FM Blurton-Jones M Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer’s disease and neuronal loss Hippocampus. 2015 25 813 26 10.1002/hipo.22405 25530343
23. Xuan A Luo M Ji W Long D Effects of engrafted neural stem cells in Alzheimer’s disease rats Neurosci Lett. 2009 450 167 71 10.1016/j.neulet.2008.12.001 19070649
24. Park D Yang G Bae DK Lee SH Yang YH Kyung J Kim D Choi EK Choi KC Kim SU Human adipose tissue‐derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice J Neurosci Res. 2013 91 660 70 10.1002/jnr.23182 23404260
25. Lee J Kuroda S Shichinohe H Ikeda J Seki T Hida K Tada M Sawada K Iwasaki Y Migration and differentiation of nuclear fluorescence‐labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice Neuropathology. 2003 23 169 80 10.1046/j.1440-1789.2003.00496.x 14570283
26. Munoz JR Stoutenger BR Robinson AP Spees JL Prockop DJ Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice Proc Natl Acad Sci U S A. 2005 102 18171 6 10.1073/pnas.0508945102 16330757
27. Teixeira FG Carvalho MM Neves-Carvalho A Panchalingam KM Behie LA Pinto L Sousa N Salgado AJ Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation Stem Cell Rev Rep. 2015 11 288 97 10.1007/s12015-014-9576-2
28. Zilka N Zilkova M Kazmerova Z Sarissky M Cigankova V Novak M Mesenchymal stem cells rescue the Alzheimer’s disease cell model from cell death induced by misfolded truncated tau Neuroscience. 2011 193 330 7 10.1016/j.neuroscience.2011.06.088 21763758
29. Lee HJ Lee JK Lee H Carter JE Chang JW Oh W Yang YS Suh J-G Lee B-H Jin HK Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer’s disease mouse model through modulation of neuroinflammation Neurobiol Aging. 2012 33 588 602 10.1016/j.neurobiolaging.2010.03.024 20471717
30. Yun H Kim H Park K Shin J Kang A Il Lee K Song S Kim Y Han S Chung H Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1–42-infused mouse model of Alzheimer’s disease Cell Death Dis. 2013 4 10.1038/cddis.2013.490 24336078
31. Yang H Xie ZH Wei LF Yang HN Yang SN Zhu ZY Wang P Zhao CP Bi JZ Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model Stem Cell Res Ther. 2013 4 1 10.1186/scrt227 23290259
32. Kim K-S Kim HS Park J-M Kim HW M-k P Lee H-S Lim DS Lee TH Chopp M Moon J Long-term immunomodulatory effect of amniotic stem cells in an Alzheimer’s disease model Neurobiol Aging 2013 34 2408 20 10.1016/j.neurobiolaging.2013.03.029 23623603
33. Naaldijk Y, Jaeger C, Fabian C, Leovsky C, Blüher A, Rudolph L, Hinze A, Stolzing A. Effect of systemic transplantation of bone marrow‐derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice. Neuropathol Appl Neurobiol. 2016.
34. Oh SH Kim HN Park H-J Shin JY Lee PH Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the Wnt signaling pathway in an Alzheimer’s disease model Cell Transplant. 2015 24 1097 109 24612635
35. Ra JC Shin IS Kim SH Kang SK Kang BC Lee HY Kim YJ Jo JY Yoon EJ Choi HJ Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans Stem Cells Dev. 2011 20 1297 308 10.1089/scd.2010.0466 21303266
36. Pang ZP Yang N Vierbuchen T Ostermeier A Fuentes DR Yang TQ Citri A Sebastiano V Marro S Südhof TC Induction of human neuronal cells by defined transcription factors Nature. 2011 476 220 3 21617644
37. Liu X Li F Stubblefield EA Blanchard B Richards TL Larson GA He Y Huang Q Tan A-C Zhang D Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells Cell Res. 2012 22 321 32 10.1038/cr.2011.181 22105488
38. Eckert A Huang L Gonzalez R Kim H-S Hamblin MH Lee J-P Bystander effect fuels human induced pluripotent stem cell‐derived neural stem cells to quickly attenuate early stage neurological deficits after stroke Stem Cells Transl Med. 2015 4 841 51 10.5966/sctm.2014-0184 26025980
39. Fujiwara N Shimizu J Takai K Arimitsu N Saito A Kono T Umehara T Ueda Y Wakisaka S Suzuki T Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells Neurosci Lett. 2013 557 129 34 10.1016/j.neulet.2013.10.043 24466594
40. Hallett PJ Deleidi M Astradsson A Smith GA Cooper O Osborn TM Sundberg M Moore MA Perez-Torres E Brownell A-L Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson’s disease Cell Stem Cell. 2015 16 269 74 10.1016/j.stem.2015.01.018 25732245
41. Balez R Steiner N Engel M Muñoz SS Lum JS Wu Y Wang D Vallotton P Sachdev P O’Connor M Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease Sci Report. 2016 6 31450 10.1038/srep31450
42. Hossini AM Megges M Prigione A Lichtner B Toliat MR Wruck W Schröter F Nuernberg P Kroll H Makrantonaki E Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks BMC Genomics. 2015 16 1 10.1186/1471-2164-16-1 25553907
43. Muratore CR Rice HC Srikanth P Callahan DG Shin T Benjamin LN Walsh DM Selkoe DJ Young-Pearse TL The familial Alzheimer’s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons Hum Mol Genet. 2014 23 3523 36 10.1093/hmg/ddu064 24524897
44. Truong A Si E Duncan T Valenzuela M Modeling neurodegenerative disorders in adult somatic cells: a critical review Front Biol. 2016 11 232 45 10.1007/s11515-016-1413-3
45. Kim HJ Seo SW Chang JW Lee JI Kim CH Chin J Choi SJ Kwon H Yun HJ Lee JM Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase 1 clinical trial Alzheimers Dement. 2015 1 95 102
46. Vertelov G Kharazi L Muralidhar M Sanati G Tankovich T Kharazi A High targeted migration of human mesenchymal stem cells grown in hypoxia is associated with enhanced activation of RhoA Stem Cell Res Ther. 2013 4 1 10.1186/scrt153 23290259
47. Cummings JL Morstorf T Zhong K Alzheimer’s disease drug-development pipeline: few candidates, frequent failures Alzheimers Res Ther. 2014 6 37 44 10.1186/alzrt269 25024750
48. Thirabanjasak D Tantiwongse K Thorner PS Angiomyeloproliferative lesions following autologous stem cell therapy J Am Soc Nephrol. 2010 21 1218 22 10.1681/ASN.2009111156 20558536
49. Amariglio N Hirshberg A Scheithauer BW Cohen Y Loewenthal R Trakhtenbrot L Paz N Koren-Michowitz M Waldman D Leider-Trejo L Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient PLoS Med. 2009 6 10.1371/journal.pmed.1000029 19226183
50. Fazel SS Angoulvant D Butany J Weisel RD Li R-K Mesenchymal stem cells engineered to overexpress stem cell factor improve cardiac function but have malignant potential J Thorac Cardiovasc Surg. 2008 136 1388 9 10.1016/j.jtcvs.2007.11.068 19026843
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.