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PloS one, v.11 no.2, 2016년, pp.e0149148 -
Lobbens, Eva S. (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) , Foderà, Vito (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) , Nyberg, Nils T. (Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) , Andersen, Kirsten (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) , Jäger, Anna K. (Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) , Jorgensen, Lene (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) , van de Weert, Marco (Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark)
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Protein fibrillation is the pathological hallmark of several neurodegenerative diseases and also complicates the manufacturing and use of protein drugs. As a case study, the inhibitory activity of the natural compound aloin against insulin fibrillation was investigated. Based on Thioflavin T assays,...
1 Shikama Y , Kitazawa Ji , Yagihashi N , Uehara O , Murata Y , Yajima N , et al Localized Amyloidosis at the Site of Repeated Insulin Injection in a Diabetic Patient . Internal Med . 2010 ; 49 ( 5 ): 397 – 401 . 20190472
2 Dobson CM . Protein misfolding, evolution and disease . Trends in Biochem Sci . 1999 ; 24 ( 9 ): 329 – 32 . 10470028
3 Hong DP , Ahmad A , Fink AL . Fibrillation of Human Insulin A and B Chains . Biochemistry . 2006 ; 45 ( 30 ): 9342 – 53 . 16866381
4 Rasmussen T , Tantipolphan R , van de Weert M , Jiskoot W . The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation . Pharm Res . 2010 ; 27 ( 7 ): 1337 – 47 . 10.1007/s11095-010-0116-8 20333453
5 Groenning M , Frokjaer S , Vestergaard B . Formation Mechanism of Insulin Fibrils and Structural Aspects of the Insulin Fibrillation Process . Curr Protein Pept Sci . 2009 ; 10 ( 5 ): 509 – 528 . 19538143
6 Gibson TJ , Murphy RM . Inhibition of insulin fibrillogenesis with targeted peptides . Protein Sci . 2006 ; 15 ( 5 ): 1133 – 41 . 16597825
7 Krebs MRH , Bromley EHC , Donald AM . The binding of thioflavin-T to amyloid fibrils: localisation and implications . J Struct Biol . 2005 ; 149 ( 1 ): 30 – 7 . 15629655
8 Amini R , Yazdanparast R , Bahramikia S . Apigenin reduces human insulin fibrillation in vitro and protects SK-N-MC cells against insulin amyloids . Int J Biol Macromol . 2013 ; 60 ( 0 ): 334 – 40 . 23777711
9 Ivanova MI , Sievers SA , Sawaya MR , Wall JS , Eisenberg D . Molecular basis for insulin fibril assembly . P Natl Acad Sci. USA 2009 11 10 ; 106 ( 45 ): 18990 – 5 .
10 Gibson TJ , Murphy RM . Inhibition of insulin fibrillogenesis with targeted peptides . Protein Sci . 2006 5 1 ; 15 ( 5 ): 1133 – 41 . 16597825
11 Li Xz , Zhang Sn , Liu Sm , Lu F . Recent advances in herbal medicines treating Parkinson's disease . Fitoterapia . 2013 1 ; 84 ( 0 ): 273 – 85 . 23266574
12 Calcul L , Zhang B , Jinwal UK , Dickey CA , Baker BJ . Natural products as a rich source of tau-targeting drugs for Alzheimer's disease . Future Med Chem 2012 8 28 ; 4 ( 13 ): 1751 – 61 . 10.4155/fmc.12.124 22924511
13 Stefani M , Rigacci S . Protein folding and aggregation into amyloid: The interference by natural phenolic compounds . Int J Mol Sci 2013 ; 14 ( 6 ): 12411 – 57 . 10.3390/ijms140612411 23765219
14 Liu KN , Lai CM , Lee YT , Wang SN , Chen RPY , Jan JS , et al Curcumin's pre-incubation temperature affects its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme . BBA-Gen Subjects . 2012 ; 1820 ( 11 ): 1774 – 86 .
15 Wamer WG , Vath P , Falvey DE . In vitro studies on the photobiological properties of aloe emodin and aloin A . Free Radical Bio Med . 2003 ; 34 ( 2 ): 233 – 42 . 12521605
16 Esmat AY , Said MM , Khalil SA . Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities . Pharm Biol . 2014 ; 1 – 9 .
17 Ding WJ , Wu XF , Zhong JS , Wan JZ . Effects of temperature, pH and light on the stability of aloin A and characterisation of its major degradation products . Int J Food Sci Technol . 2014 ; 49 ( 7 ): 1773 – 9 .
18 Groenning M , Norrman M , Flink JM , van de Weert M , Bukrinsky JT , Schluckebier G , et al Binding mode of Thioflavin T in insulin amyloid fibrils . J Struct Biol . 2007 ; 159 ( 3 ): 483 – 97 . 17681791
19 Groenning M , Olsen L , van de Weert M , Flink JM , Frokjaer S , Jørgensen FS . Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities . J Struct Biol . 2007 ; 158 ( 3 ): 358 – 69 . 17289401
20 Foderà V , Librizzi F , Groenning M , van de Weert M , Leone M . Secondary Nucleation and Accessible Surface in Insulin Amyloid Fibril Formation . J Phys Chem B . 2008 ; 112 ( 12 ): 3853 – 8 . 10.1021/jp710131u 18311965
21 Smith MI , Foderà V , Sharp JS , Roberts CJ , Donald AM . Factors affecting the formation of insulin amyloid spherulites . Colloids and Surfaces B: Biointerfaces . 2012 ; 89 ( 0 ): 216 – 22 . 21982213
22 Foderà V , Pagliara S , Otto O , Keyser UF , Donald AM . Microfluidics Reveals a Flow-Induced Large-Scale Polymorphism of Protein Aggregates . J Phys Chem Lett . 2012 ; 3 ( 19 ): 2803 – 7 .
23 Zhu JJ , Zhang CF , Zhang M , Bligh SWA , Yang L , Wang ZM , et al Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography-circular dichroism analysis . J Chromatogr A . 2010 8 13 ; 1217 ( 33 ): 5384 – 8 . 10.1016/j.chroma.2010.05.039 20619416
24 Manitto P , Monti D , Speranza G . Studies on aloe. Part 6. Conformation and absolute configuration of aloins A and B and related 10-C-glucosyl-9-anthrones . J Chem Soc, Perkin Trans . 1990 ; 1 : 1297 – 300 .
25 Nielsen L , Khurana R , Coats A , Frokjaer S , Brange J , Vyas S , et al Effect of Environmental Factors on the Kinetics of Insulin Fibril Formation: Elucidation of the Molecular Mechanism . Biochemistry . 200; 40 ( 20 ): 6036 – 46 . 11352739
26 Vassar PS , Culling CFA . Fluorescent stains, with special reference to amyloid and connective tissues . Arch Pathol . 1959 ; 68 : 487 – 94 . 13841452
27 Hudson SA , Ecroyd H , Kee TW , Carver JA . The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds . FEBS J . 2009 ; 276 ( 20 ): 5960 – 72 . 10.1111/j.1742-4658.2009.07307.x 19754881
28 Li J , Zhu M , Rajamani S , Uversky VN , Fink AL . Rifampicin Inhibits α-Synuclein Fibrillation and Disaggregates Fibrils . Chem Biol 2004 ; 11 ( 11 ): 1513 – 21 . 15556002
29 Zhu M , Rajamani S , Kaylor J , Han S , Zhou F , Fink AL . The Flavonoid Baicalein Inhibits Fibrillation of α-Synuclein and Disaggregates Existing Fibrils . J Biol Chem 2004 ; 279 ( 26 ): 26846 – 57 . 15096521
30 Palhano FL , Lee J , Grimster NP , Kelly JW . Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils . J Am Chem Soc 2013 ; 135 ( 20 ): 7503 – 10 . 10.1021/ja3115696 23611538
31 Dewick Paul M . Medicinal natural products 3. rd. ed. Chichester : Wiley ; 2009 .
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