$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

GHK-Cu may Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes 원문보기

Cosmetics, v.2 no.3, 2015년, pp.236 - 247  

Pickart, Loren (Skin Biology, Research & Development Department, 4122 Factoria Boulevard SE, Suite No. 200, Bellevue, WA 98006, USA) ,  Vasquez-Soltero, Jessica (Skin Biology, Research & Development Department, 4122 Factoria Boulevard SE, Suite No. 200, Bellevue, WA 98006, USA) ,  Margolina, Anna (Skin Biology, Research & Development Department, 4122 Factoria Boulevard SE, Suite No. 200, Bellevue, WA 98006, USA)

Abstract AI-Helper 아이콘AI-Helper

The copper binding tripeptide GHK (glycyl-l-histidyl-l-lysine) is a naturally occurring plasma peptide that significantly declines during human aging. It has been established that GHK:Copper(2+) improves wound healing and tissue regeneration and stimulates collagen and decorin production. GHK-Cu als...

참고문헌 (64)

  1. Young Antioxidants in health and disease J. Clin. Pathol. 2001 10.1136/jcp.54.3.176 54 176 

  2. 10.1155/2014/860479 Godic, A., Poljsak, B., Adamic, M., and Dahmane, R. (2014). The role of antioxidants in skin cancer prevention and treatment. Oxid. Med. Cell. Longev., 2014. 

  3. Wang Dual effects of antioxidants in neurodegeneration: Direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation Curr. Pharm. Des. 2006 10.2174/138161206778343109 12 3521 

  4. Pickart The human tri-peptide GHK and tissue remodeling J. Biomater. Sci. Polym. Ed. 2008 10.1163/156856208784909435 19 969 

  5. Pickart A possible mechanism whereby skin remodeling may suppress cancer metastasis genes Wound Repair and Regeneration 2011 Volume 19 A62 

  6. Pickart, L. (1973). A Tripeptide in Human Plasma that Increases the Survival of Hepatocytes and the Growth of Hepatoma Cells. [Ph.D. Thesis, University of California]. 

  7. Pickart Growth-modulating tripeptide (glycylhistidyllysine): Association with copper and iron in plasma, and stimulation of adhesiveness and growth of hepatoma cells in culture by tripeptide-metal ion complexes J. Cell. Physiol. 1980 10.1002/jcp.1041020205 102 129 

  8. Schlesinger Growth-modulating serum tripeptide is glycyl-histidyl-lysine Cell. Mol. Life Sci. 1977 10.1007/BF02002806 33 324 

  9. Lane SPARC is a source of copper-binding peptides that stimulate angiogenesis J. Cell. Biol. 1994 10.1083/jcb.125.4.929 125 929 

  10. Pickart Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells Nature 1980 10.1038/288715a0 288 715 

  11. Lau The interaction of copper(II) and glycyl-l-histidyl-l-lysine, a growth-modulating tripeptide from plasma Biochem. J. 1981 10.1042/bj1990649 199 649 

  12. Pickart The use of glycylhistidyllysine in culture systems In Vitro 1981 10.1007/BF02633506 17 459 

  13. Williams Glycyl-l-histidyl-l-lysine, a growth promoting factor for human cells Cytobios 1979 27 19 

  14. Barra Effects of glycyl-histidyl-lysine on Morris hepatoma 7777 cells Cytobios 1986 52 99 

  15. Pollard Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts Arch. Facial Plast. Surg. 2005 10.1001/archfaci.7.1.27 7 27 

  16. Lamb The connectivity map: A new tool for biomedical research Nat. Rev. Cancer 2007 10.1038/nrc2044 7 54 

  17. Iorio Discovery of drug mode of action and drug repositioning from transcriptional responses Proc. Natl. Acad. Sci. 2010 10.1073/pnas.1000138107 107 14621 

  18. Hong A “metastasis-prone” signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics Clin. Exp. Metastasis 2010 10.1007/s10585-010-9305-4 27 83 

  19. Campbell A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK Genome Med. 2012 4 1 

  20. 10.1155/2014/151479 Pickart, L., Vasquez-Soltero, J.M., and Margolina, A. (2014). GHK and DNA: Resetting the human genome to health. Biomed. Res. Int., 2014. 

  21. Pickart, L. (1988). Use of GHL-Cu as a Wound-Healing and Anti-Inflammatory Agent. (No. 4,760,051), U.S. Patent. 

  22. Downey Acceleration of wound healing using glycyl-histidyl-lysine copper (II) Surg. Forum 1985 25 573 

  23. Maquart Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ FEBS Lett. 1988 10.1016/0014-5793(88)80509-X 238 343 

  24. Maquart In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ in rat experimental wounds J. Clin. Invest. 1993 10.1172/JCI116842 92 2368 

  25. Wegrowski Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ Life Sci. 1992 10.1016/0024-3205(92)90504-I 51 1049 

  26. Simeon The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures Life Sci. 2000 10.1016/S0024-3205(00)00803-1 67 2257 

  27. Simeon Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu(2+) J. Invest. Dermatol. 2000 10.1046/j.1523-1747.2000.00166.x 115 962 

  28. Gul The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits Vet. Dermatol. 2008 10.1111/j.1365-3164.2007.00647.x 19 7 

  29. Cangul Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits Vet. Dermatol. 2006 10.1111/j.1365-3164.2006.00551.x 17 417 

  30. Pickart, L. (1992). Method of Using Copper(II) Containing Compounds to Accelerate Wound Healing. (No. 5,164,367), U.S. Patent. 

  31. Arul A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices Life Sci. 2007 10.1016/j.lfs.2006.09.018 80 275 

  32. Canapp The effect of topical tripeptide-copper complex on healing of ischemic open wounds Vet. Surg. 2003 10.1111/j.1532-950X.2003.00515.x 32 515 

  33. Swaim Effect of locally injected medications on healing of pad wounds in dogs Am. J. Vet. Res. 1996 10.2460/ajvr.1996.57.03.394 57 394 

  34. Thomas The influence of medium components on Cu2+-dependent oxidation of low-density lipoproteins and its sensitivity to superoxide dismutase Biochim. Biophys. Acta 1992 10.1016/0005-2760(92)90256-U 1128 50 

  35. Beretta Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): Characterization of conjugation products by ESI-MSn and theoretical calculations J. Pharm Biomed. Anal. 2008 10.1016/j.jpba.2008.02.012 47 596 

  36. Beretta Glycyl-histidyl-lysine (GHK) is a quencher of α,β-4-hydroxy-trans-2-nonenal: A comparison with carnosine. Insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques Chem. Res. Toxicol. 2007 10.1021/tx700185s 20 1309 

  37. Cebrian New anti-RNS and -RCS products for cosmetic treatment Int. J. Cosmet. Sci. 2005 10.1111/j.1467-2494.2005.00279.x 27 271 

  38. Smakhtin [Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane] Patol. Fiziol. Eksp. Ter. Russ. 2003 2 19 

  39. Cherdakov Synergetic antioxidant and reparative action of thymogen, dalargin and peptide Gly-His-Lys in tubular bone fractures Exp. Biol. Med. 2010 4 15 

  40. Miller Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation Adv. Exp. Med. Biol. 1990 10.1007/978-1-4684-5730-8_11 264 79 

  41. Pickart, L. (1992). Anti-Oxidative and Anti-Inflammatory Metal:Peptide Complexes and Uses Thereof. (No. 07/478,091), U.S. Patent. 

  42. Pickart GHK, the human skin remodeling peptide, induces anti-cancer expression of numerous caspase, growth regulatory, and DNA repair genes J. Anal. Oncol. 2014 3 79 

  43. Mariappan NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes Cardiovasc. Res. 2010 10.1093/cvr/cvp305 85 473 

  44. Vermeij Proteomic identification of in vivo interactors reveals novel function of skin cornification proteins J. Proteome Res. 2012 10.1021/pr300310b 11 3068 

  45. Vermeij ROS quenching potential of the epidermal cornified cell envelope J. Invest. Dermatol. 2011 10.1038/jid.2010.433 131 1435 

  46. Liu Wound repair and anti-oxidative capacity is regulated by ITGB4 in airway epithelial cells Mol. Cell. Biochem. 2010 10.1007/s11010-010-0457-y 341 259 

  47. Elsoe Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL Atherosclerosis 2012 10.1016/j.atherosclerosis.2011.11.031 221 91 

  48. Kempster Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice Am. J. Physiol. Endocrinol. Metab. 2012 10.1152/ajpendo.00357.2011 302 E103 

  49. Novick Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response Immunity 1999 10.1016/S1074-7613(00)80013-8 10 127 

  50. Song Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells J. Cell. Biochem. 2010 10.1002/jcb.22617 110 1063 

  51. Giguere G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3 J. Biol. Chem. 2014 10.1074/jbc.M114.578393 289 33245 

  52. 10.1186/1471-230X-14-44 Gong, Y., Wang, G., Gong, Y., Yan, J., Chen, Y., and Burczynski, F.J. (2014). Hepatoprotective role of liver fatty acid binding protein in acetaminophen induced toxicity. BMC Gastroenterol., 14. 

  53. Wang Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells Hepatology 2005 10.1002/hep.20857 42 871 

  54. Rosenblat Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: Relevance to diabetes Atherosclerosis 2006 10.1016/j.atherosclerosis.2005.08.026 187 74 

  55. Hussain Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection Neurochem. Int. 1996 10.1016/0197-0186(95)00114-X 29 145 

  56. Viarengo Antioxidant role of metallothioneins: A comparative overview Cell. Mol. Biol. 2000 46 407 

  57. Henry Antioxidant and cyclooxygenase activities of fatty acids found in food J. Agric. Food Chem. 2002 10.1021/jf0114381 50 2231 

  58. Itahana The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense Oncogene 2015 10.1038/onc.2014.119 34 1799 

  59. Chen Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: A new therapeutic approach for the treatment of inflammatory diseases Curr. Pharm. Des. 2004 10.2174/1381612043452901 10 879 

  60. 10.1201/NOE0824759438 Elsner, P., and Maibach, H. (2005). Cosmeceuticals and Active Cosmetics: Drugs vs. Cosmetics, Marcel Dekker. 

  61. Mariappan TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: Restoration by superoxide dismutase mimetic Tempol Am. J. Physiol. Heart Circ. Physiol. 2007 10.1152/ajpheart.00376.2007 293 H2726 

  62. Hostynek Human skin penetration of a copper tripeptide in vitro as a function of skin layer Inflamm. Res. 2011 10.1007/s00011-010-0238-9 60 79 

  63. Li Oral delivery of peptides and proteins using lipid-based drug delivery systems Expert Opin. Drug Deliv. 2012 10.1517/17425247.2012.717068 9 1289 

  64. Swaminathan Liposomal delivery of proteins and peptides Expert Opin. Drug Deliv. 2012 10.1517/17425247.2012.735658 9 1489 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로